4TTV
Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004829 | molecular_function | threonine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004829 | molecular_function | threonine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004829 | molecular_function | threonine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004829 | molecular_function | threonine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006435 | biological_process | threonyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue BC9 A 801 |
| Chain | Residue |
| A | SER386 |
| A | LEU567 |
| A | HIS590 |
| A | GLY387 |
| A | HIS388 |
| A | CYS413 |
| A | ARG442 |
| A | GLN460 |
| A | TYR540 |
| A | THR560 |
| A | ASP564 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | CYS413 |
| A | HIS464 |
| A | HIS590 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue BC9 B 801 |
| Chain | Residue |
| B | GLY387 |
| B | HIS388 |
| B | CYS413 |
| B | ARG442 |
| B | GLN460 |
| B | TYR540 |
| B | THR560 |
| B | ASP564 |
| B | LEU567 |
| B | HIS590 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 802 |
| Chain | Residue |
| B | CYS413 |
| B | HIS464 |
| B | HIS590 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue BC9 C 801 |
| Chain | Residue |
| C | HIS388 |
| C | MET411 |
| C | CYS413 |
| C | ARG442 |
| C | TYR540 |
| C | THR560 |
| C | ASP564 |
| C | LEU567 |
| C | HIS590 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 802 |
| Chain | Residue |
| C | CYS413 |
| C | HIS464 |
| C | HIS590 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue BC9 D 801 |
| Chain | Residue |
| D | HIS388 |
| D | MET411 |
| D | CYS413 |
| D | ARG442 |
| D | TYR540 |
| D | THR560 |
| D | ASP564 |
| D | LEU567 |
| D | HIS590 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ZN D 802 |
| Chain | Residue |
| D | CYS413 |
| D | HIS464 |
| D | HIS590 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for Ligand ASN B 533 bound to ASN B 497 |
| Chain | Residue |
| B | ASN497 |
| B | LEU498 |
| B | SER499 |
| B | LEU532 |
| B | SER534 |
| B | GLY535 |
| B | ASP536 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GLN C 666 and ASN C 693 |
| Chain | Residue |
| C | ILE662 |
| C | ARG663 |
| C | ASN664 |
| C | ALA665 |
| C | LEU667 |
| C | ALA668 |
| C | GLN669 |
| C | ARG689 |
| C | THR690 |
| C | ARG691 |
| C | ASP692 |
| C | LYS694 |
| C | VAL695 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide GLN D 666 and ASN D 693 |
| Chain | Residue |
| D | ILE662 |
| D | ARG663 |
| D | ASN664 |
| D | ALA665 |
| D | LEU667 |
| D | ALA668 |
| D | GLN669 |
| D | ARG689 |
| D | THR690 |
| D | ARG691 |
| D | ASP692 |
| D | LYS694 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
