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1F7D
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS
Descriptor:POL POLYPROTEIN, MAGNESIUM ION
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-26
Release date:2000-09-06
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7K
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7N
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN, MAGNESIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7O
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7P
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN, URIDINE-5'-DIPHOSPHATE
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7Q
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN, DEOXYURIDINE-5'-TRIPHOSPHATE
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1F7R
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CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Descriptor:POL POLYPROTEIN, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE
Authors:Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Deposit date:2000-06-27
Release date:2000-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
Acta Crystallogr.,Sect.D, 56, 2000
1DUT
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FIV DUTP PYROPHOSPHATASE
Descriptor:DUTP PYROPHOSPHATASE, MAGNESIUM ION
Authors:Prasad, G.S., Stura, E.A., Mcree, D.E., Laco, G.S., Hasselkus-Light, C., Elder, J.H., Stout, C.D.
Deposit date:1996-09-15
Release date:1997-01-27
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of dUTP pyrophosphatase from feline immunodeficiency virus.
Protein Sci., 5, 1996
1ZP8
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HIV PROTEASE WITH INHIBITOR AB-2
Descriptor:Pol polyprotein, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE
Authors:Brik, A., Alexandratos, J.N., Elder, J.H., Olson, A.J., Wlodawer, A., Goodsell, D.S., Wong, C.H.
Deposit date:2005-05-16
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.
Chembiochem, 6, 2005
1ZPA
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HIV PROTEASE WITH SCRIPPS AB-3 INHIBITOR
Descriptor:Pol polyprotein, TERT-BUTYL 4-[({[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL}AMINO)CARBONYL]BENZYLCARBAMATE
Authors:Brik, A., Alexandratos, J., Lin, Y.C., Elder, J.H., Olson, A.J., Wlodawer, A., Goodsell, D.S., Wong, C.H.
Deposit date:2005-05-16
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors
Chembiochem, 6, 2005
2AZ8
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HIV-1 PROTEASE NL4-3 IN COMPLEX WITH INHIBITOR, TL-3
Descriptor:PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Heaslet, H., Kutilek, V., Morris, G.M., Lin, Y.-C., Elder, J.H., Torbett, B.E., Stout, C.D.
Deposit date:2005-09-09
Release date:2006-02-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2AZ9
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HIV-1 PROTEASE NL4-3 1X MUTANT
Descriptor:PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Heaslet, H., Kutilek, V., Morris, G.M., Lin, Y.-C., Elder, J.H., Torbett, B.E., Stout, C.D.
Deposit date:2005-09-09
Release date:2006-02-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2AZB
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HIV-1 PROTEASE NL4-3 3X MUTANT IN COMPLEX WITH INHIBITOR, TL-3
Descriptor:PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Heaslet, H., Kutilek, V., Morris, G.M., Lin, Y.-C., Elder, J.H., Torbett, B.E., Stout, C.D.
Deposit date:2005-09-09
Release date:2006-02-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2AZC
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HIV-1 PROTEASE NL4-3 6X MUTANT
Descriptor:PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Heaslet, H., Kutilek, V., Morris, G.M., Lin, Y.-C., Elder, J.H., Torbett, B.E., Stout, C.D.
Deposit date:2005-09-10
Release date:2006-02-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2HAH
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THE STRUCTURE OF FIV 12S PROTEASE IN COMPLEX WITH TL-3
Descriptor:Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Heaslet, H., Lin, Y.C., Elder, J.H., Stout, C.D.
Deposit date:2006-06-12
Release date:2007-02-13
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.
Retrovirology, 4, 2007
2HB2
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STRUCTURE OF HIV PROTEASE 6X MUTANT IN APO FORM
Descriptor:Protease
Authors:Heaslet, H., Tam, K., Elder, J.H., Stout, C.D.
Deposit date:2006-06-13
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
2HB4
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STRUCTURE OF HIV PROTEASE NL4-3 IN AN UNLIGANDED STATE
Descriptor:Protease, MAGNESIUM ION, R-1,2-PROPANEDIOL
Authors:Heaslet, H., Tam, K., Elder, J.H., Stout, C.D.
Deposit date:2006-06-13
Release date:2007-06-26
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
2HC0
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STRUCTURE OF HIV PROTEASE 6X MUTANT IN COMPLEX WITH AB-2.
Descriptor:Protease, BROMIDE ION, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE
Authors:Heaslet, H., Brik, A., Lin, Y.-C., Elder, J.H., Stout, C.D.
Deposit date:2006-06-14
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of HIV Protease 6X Mutant in complex with AB-2
To be Published
2PC0
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APO WILD-TYPE HIV PROTEASE IN THE OPEN CONFORMATION
Descriptor:Protease, MAGNESIUM ION, R-1,2-PROPANEDIOL
Authors:Heaslet, H., Rosenfeld, R., Giffin, M.J., Elder, J.H., McRee, D.E., Stout, C.D.
Deposit date:2007-03-29
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
3OGP
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CRYSTAL STRUCTURE OF 6S-98S FIV PROTEASE WITH DARUNAVIR BOUND
Descriptor:FIV Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, DIMETHYL SULFOXIDE
Authors:Lin, Y.-C., Perryman, A.L., Elder, J.H., Stout, C.D.
Deposit date:2010-08-17
Release date:2011-06-08
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Acta Crystallogr.,Sect.D, 67, 2011
3OGQ
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CRYSTAL STRUCTURE OF 6S-98S FIV PROTEASE WITH LOPINAVIR BOUND
Descriptor:FIV protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, DIMETHYL SULFOXIDE
Authors:Lin, Y.-C., Perryman, A.L., Elder, J.H., Stout, C.D.
Deposit date:2010-08-17
Release date:2011-06-08
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Acta Crystallogr.,Sect.D, 67, 2011
3TLH
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
Descriptor:PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
5FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
6FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1B11
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STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093
Descriptor:PROTEIN (Feline Immunodeficiency Virus PROTEASE), SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Gustchina, A., Li, M., Wlodawer, A.
Deposit date:1998-11-25
Release date:1998-12-02
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
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