Author results

1KXQ
  • Download 1kxq
  • View 1kxq
Molmil generated image of 1kxq
CAMELID VHH DOMAIN IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:alpha-amylase, pancreatic, antibody VHH fragment CABAMD9, ...
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXT
  • Download 1kxt
  • View 1kxt
Molmil generated image of 1kxt
CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, IMMUNOGLOBULIN VHH FRAGMENT, ...
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXV
  • Download 1kxv
  • View 1kxv
Molmil generated image of 1kxv
CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
4GRW
  • Download 4grw
  • View 4grw
Molmil generated image of 4grw
STRUCTURE OF A COMPLEX OF HUMAN IL-23 WITH 3 NANOBODIES (LLAMA VHHS)
Descriptor:Interleukin-23 subunit alpha, Interleukin-12 subunit beta, Nanobody 124C4, ...
Authors:Desmyter, A., Spinelli, S., Button, C., Saunders, M., de Haard, H., Rommelaere, H., Union, A., Cambillau, C.
Deposit date:2012-08-27
Release date:2014-02-19
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.
Front Immunol, 8, 2017
1G6V
  • Download 1g6v
  • View 1g6v
Molmil generated image of 1g6v
COMPLEX OF THE CAMELID HEAVY-CHAIN ANTIBODY FRAGMENT CAB-CA05 WITH BOVINE CARBONIC ANHYDRASE
Descriptor:CARBONIC ANHYDRASE, ANTIBODY HEAVY CHAIN, ZINC ION
Authors:Desmyter, A., Decanniere, K., Muyldermans, S., Wyns, L.
Deposit date:2000-11-08
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
J.Biol.Chem., 276, 2001
1MEL
  • Download 1mel
  • View 1mel
Molmil generated image of 1mel
CRYSTAL STRUCTURE OF A CAMEL SINGLE-DOMAIN VH ANTIBODY FRAGMENT IN COMPLEX WITH LYSOZYME
Descriptor:VH SINGLE-DOMAIN ANTIBODY, LYSOZYME
Authors:Desmyter, A., Transue, T.R., Arbabi Gharoudi, M., Dao Thi, M., Poortmans, F., Hamers, R., Muyldermans, S., Wyns, L.
Deposit date:1996-06-06
Release date:1997-06-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.
Nat.Struct.Biol., 3, 1996
4HEM
  • Download 4hem
  • View 4hem
Molmil generated image of 4hem
LLAMA VHH-02 BINDER OF ORF49 (RBP) FROM LACTOCOCCAL PHAGE TP901-1
Descriptor:BPP, Anti-baseplate TP901-1 Llama vHH 02
Authors:Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C.
Deposit date:2012-10-04
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
4HEP
  • Download 4hep
  • View 4hep
Molmil generated image of 4hep
COMPLEX OF LACTOCOCCAL PHAGE TP901-1 WITH A LLAMA VHH (VHH17) BINDER (NANOBODY)
Descriptor:BPP, vHH17 domain, SULFATE ION
Authors:Desmyter, A., Spinelli, S., Farenc, C., Blangy, S., Bebeacua, C., van Sinderen, D., Mahony, J., Cambillau, C.
Deposit date:2012-10-04
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
4IOS
  • Download 4ios
  • View 4ios
Molmil generated image of 4ios
STRUCTURE OF PHAGE TP901-1 RBP (ORF49) IN COMPLEX WITH NANOBODY 11.
Descriptor:BPP, Llama nanobody 11, GLYCEROL
Authors:Desmyter, A., Farenc, C., Mahony, J., Spinelli, S., Bebeacua, C., Blangy, S., Veesler, D., van Sinderen, D., Cambillau, C.
Deposit date:2013-01-08
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Viral infection modulation and neutralization by camelid nanobodies
Proc.Natl.Acad.Sci.USA, 110, 2013
1BZQ
  • Download 1bzq
  • View 1bzq
Molmil generated image of 1bzq
COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A
Descriptor:PROTEIN (RNASE A), PROTEIN (ANTIBODY CAB-RN05), PHOSPHATE ION
Authors:Decanniere, K., Desmyter, A., Gahroudhi, M., Lauwereys, M., Muyldermans, S., Wyns, L.
Deposit date:1998-11-03
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Structure Fold.Des., 7, 1999
1JTO
  • Download 1jto
  • View 1jto
Molmil generated image of 1jto
DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES
Descriptor:Vh Single-Domain Antibody, Lysozyme
Authors:Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L.
Deposit date:2001-08-21
Release date:2001-10-31
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1JTP
  • Download 1jtp
  • View 1jtp
Molmil generated image of 1jtp
DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES
Descriptor:Single-Domain Antibody, LYSOZYME C, SODIUM ION, ...
Authors:Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L.
Deposit date:2001-08-21
Release date:2001-12-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1JTT
  • Download 1jtt
  • View 1jtt
Molmil generated image of 1jtt
DEGENERATE INTERFACES IN ANTIGEN-ANTIBODY COMPLEXES
Descriptor:Vh Single-Domain Antibody, Lysozyme, SODIUM ION, ...
Authors:Decanniere, K., Transue, T.R., Desmyter, A., Maes, D., Muyldermans, S., Wyns, L.
Deposit date:2001-08-22
Release date:2001-12-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1OP9
  • Download 1op9
  • View 1op9
Molmil generated image of 1op9
COMPLEX OF HUMAN LYSOZYME WITH CAMELID VHH HL6 ANTIBODY FRAGMENT
Descriptor:HL6 camel VHH fragment, Lysozyme C
Authors:Dumoulin, M., Last, A.M., Desmyter, A., Decanniere, K., Canet, D., Larsson, G., Spencer, A., Archer, D.B., Sasse, J., Muyldermans, S., Wyns, L., Redfield, C., Matagne, A., Robinson, C.V., Dobson, C.M.
Deposit date:2003-03-05
Release date:2003-10-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
Nature, 424, 2003
4O9H
  • Download 4o9h
  • View 4o9h
Molmil generated image of 4o9h
STRUCTURE OF INTERLEUKIN-6 IN COMPLEX WITH A CAMELID FAB FRAGMENT
Descriptor:Interleukin-6, Heavy Chain of the Camelid Fab fragment 61H7, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De haard, H.J.W., Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4R90
  • Download 4r90
  • View 4r90
Molmil generated image of 4r90
ANTI CD70 LLAMA GLAMA FAB 27B3
Descriptor:Anti CD70 Llama glama Fab 27B3 Light chain, Anti CD70 Llama glama Fab 27B3 Heavy chain, GLYCEROL, ...
Authors:Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4R96
  • Download 4r96
  • View 4r96
Molmil generated image of 4r96
STRUCTURE OF A LLAMA GLAMA FAB 48A2 AGAINST HUMAN CMET
Descriptor:Llama glama Fab 48A2 against human cMet L chain, Llama glama Fab 48A2 against human cMet H chain
Authors:Klarenbeek, A., El Mazouari, K., Desmyter, A., Blanchetot, C., Hultberg, A., Roovers, R.C., Cambillau, C., Spinelli, S., Del-Favero, J., Verrips, T., de Haard, H., Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4ZS7
  • Download 4zs7
  • View 4zs7
Molmil generated image of 4zs7
STRUCTURAL MIMICRY OF RECEPTOR INTERACTION BY ANTAGONISTIC IL-6 ANTIBODIES
Descriptor:Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C., De Jonge, N., Desmyter, A., Ongenae, N., Hofman, E., Klarenbeek, A., Sadi, A., Hultberg, A., Kretz-Rommel, A., Spinelli, S., Loris, R., Cambillau, C., de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
4PIR
  • Download 4pir
  • View 4pir
Molmil generated image of 4pir
X-RAY STRUCTURE OF THE MOUSE SEROTONIN 5-HT3 RECEPTOR
Descriptor:5-hydroxytryptamine receptor 3A, VHH15, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M.B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X.-D., Poitevin, F., Vogel, H., Nury, H.
Deposit date:2014-05-09
Release date:2014-08-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of the mouse serotonin 5-HT3 receptor.
Nature, 512, 2014
4QGY
  • Download 4qgy
  • View 4qgy
Molmil generated image of 4qgy
CAMELID (LLAMA) NANOBODY N25 (VHH) AGAINST TYPE 6 SECRETION SYSTEM TSSM PROTEIN
Descriptor:nanobody n25, VH domain
Authors:Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A.
Deposit date:2014-05-26
Release date:2015-04-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
4QLR
  • Download 4qlr
  • View 4qlr
Molmil generated image of 4qlr
LLAMA NANOBODY N02 RAISED AGAINST EAEC T6SS TSSM
Descriptor:Llama nanobody n02 VH domain
Authors:Nguyen, V.S., Desmyter, A., Le, T.T.H., Durand, E., Kellenberger, C., Douzi, B., Spinelli, S., Cascales, E., Cambillau, C., Roussel, A.
Deposit date:2014-06-13
Release date:2015-04-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody.
Plos One, 10, 2015
5M2W
  • Download 5m2w
  • View 5m2w
Molmil generated image of 5m2w
STRUCTURE OF NANOBODY NB18 RAISED AGAINST TSSK FROM E. COLI T6SS
Descriptor:Llama nanobody nb8 against TssK from T6SS, SULFATE ION
Authors:Cambillau, C., Nguyen, V.S., Spinelli, S., Desmyter, A.
Deposit date:2016-10-13
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
5M2Y
  • Download 5m2y
  • View 5m2y
Molmil generated image of 5m2y
STRUCTURE OF TSSK C-TERMINAL DOMAIN FROM E. COLI T6SS
Descriptor:TssK C
Authors:Cambillau, C., Nguyen, V.S., Spinelli, S., Desmyter, A., Legrand, P.
Deposit date:2016-10-13
Release date:2017-06-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
5M30
  • Download 5m30
  • View 5m30
Molmil generated image of 5m30
STRUCTURE OF TSSK FROM T6SS EAEC IN COMPLEX WITH NANOBODY NB18
Descriptor:Type VI secretion protein, Anti-vesicular stomatitis virus N VHH
Authors:Nguyen, V.S., Cambillau, C., Spinelli, C., Desmyter, A., Legrand, P., Cascales, E.
Deposit date:2016-10-13
Release date:2017-06-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
1LJL
  • Download 1ljl
  • View 1ljl
Molmil generated image of 1ljl
WILD TYPE PI258 S. AUREUS ARSENATE REDUCTASE
Descriptor:arsenate reductase, POTASSIUM ION
Authors:Messens, J., Martins, J.C., Van Belle, K., Brosens, E., Desmyter, A., De Gieter, M., Wieruszeski, J.M., Willem, R., Wyns, L., Zegers, I.
Deposit date:2002-04-21
Release date:2002-08-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade.
Proc.Natl.Acad.Sci.USA, 99, 2002
<123>