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2XYQ
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CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX
Descriptor:PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, CHLORIDE ION, ...
Authors:Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.
Deposit date:2010-11-18
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
2XYR
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CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX
Descriptor:PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, SODIUM ION, ...
Authors:Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.
Deposit date:2010-11-18
Release date:2011-10-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
2XYV
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CRYSTAL STRUCTURE OF THE NSP16 NSP10 SARS CORONAVIRUS COMPLEX
Descriptor:PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, SODIUM ION, ...
Authors:Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Ortiz-Lombardia, M., Lescar, J., Canard, B.
Deposit date:2010-11-19
Release date:2011-10-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.
Plos Pathog., 7, 2011
4UCI
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-03
Release date:2015-10-14
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UCJ
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, SULFATE ION
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-03
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UCK
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, S-ADENOSYLMETHIONINE
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-03
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UCL
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, SULFATE ION
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-03
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UCY
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, SULFATE ION
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-05
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UCZ
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, ZINC ION, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-05
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
4UD0
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X-RAY STRUCTURE AND ACTIVITIES OF AN ESSENTIAL MONONEGAVIRALES L- PROTEIN DOMAIN
Descriptor:RNA-DIRECTED RNA POLYMERASE L, SULFATE ION, ZINC ION, ...
Authors:Paesen, G.C., Collet, A., Sallamand, C., Debart, F., Vasseur, J.J., Canard, B., Decroly, E., Grimes, J.M.
Deposit date:2014-12-05
Release date:2015-11-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.
Nat.Commun., 6, 2015
5M5B
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS5 METHYLTRANSFERASE
Descriptor:NS5 methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION, ...
Authors:Barral, K., Ortiz Lombardia, M., Coutard, B., Decroly, E., Lichiere, J.
Deposit date:2016-10-21
Release date:2016-12-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J. Virol., 91, 2017
3ELD
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WESSELSBRON METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN
Descriptor:Methyltransferase, SINEFUNGIN, SULFATE ION
Authors:Bollati, M., Milani, M., Mastrangelo, E., Ricagno, S., Bolognesi, M.
Deposit date:2008-09-22
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELU
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND GPPPG
Descriptor:Methyltransferase, SULFATE ION, S-ADENOSYLMETHIONINE, ...
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELY
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOHCY
Descriptor:Methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMB
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND 7MEGPPPG
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ...
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN AND 7MEGPPPA
Descriptor:methyltransferase, SINEFUNGIN, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
2P3L
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3O
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3Q
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPG AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, DIGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P40
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPG
Descriptor:type II methyltransferase, SULFATE ION, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-11
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P41
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPG2'OME AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-11
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
4CTJ
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
Descriptor:NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, 2,3-dihydro-1-benzofuran-5-carboxylic acid, ...
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2014-03-14
Release date:2014-04-16
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
4CTK
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4
Descriptor:POLYPROTEIN, S-ADENOSYLMETHIONINE, thieno[2,3-b]pyrazin-7-amine, ...
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2014-03-14
Release date:2014-04-16
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
5E9Q
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174
Descriptor:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid
Authors:Barral, K., Bricogne, G., Sharff, A.
Deposit date:2015-10-15
Release date:2016-10-26
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
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