8FU3

Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor

Summary for 8FU3

• Entry DOI: 10.2210/pdb8fu3/pdb
• EMDB information: 29452
• Descriptor: RNA-directed RNA polymerase L, Phosphoprotein, 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide (3 entities in total)
• Functional Keywords: rsv, polymerase, non-nucleoside inhibitor, viral protein, transferase
• Biological source: Human respiratory syncytial virus A2; More
• Total number of polymer chains: 5
• Total formula weight: 371310.85

Authors

Yu, X.,Abeywickrema, P.,Bonneux, B.,Behera, I.,Jacoby, E.,Fung, A.,Adhikary, S.,Bhaumik, A.,Carbajo, R.J.,Bruyn, S.D.,Miller, R.,Patrick, A.,Pham, Q.,Piassek, M.,Verheyen, N.,Shareef, A.,Sutto-Ortiz, P.,Ysebaert, N.,Vlijmen, H.V.,Jonckers, T.H.M.,Herschke, F.,McLellan, J.S.,Decroly, E.,Fearns, R.,Grosse, S.,Roymans, D.,Sharma, S.,Rigaux, P.,Jin, Z. (deposition date: 2023-01-16, release date: 2023-11-01)

• Primary citation: Yu, X.,Abeywickrema, P.,Bonneux, B.,Behera, I.,Anson, B.,Jacoby, E.,Fung, A.,Adhikary, S.,Bhaumik, A.,Carbajo, R.J.,De Bruyn, S.,Miller, R.,Patrick, A.,Pham, Q.,Piassek, M.,Verheyen, N.,Shareef, A.,Sutto-Ortiz, P.,Ysebaert, N.,Van Vlijmen, H.,Jonckers, T.H.M.,Herschke, F.,McLellan, J.S.,Decroly, E.,Fearns, R.,Grosse, S.,Roymans, D.,Sharma, S.,Rigaux, P.,Jin, Z.; Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.; Commun Biol, 6:1074-1074, 2023; PubMed: 37865687; DOI: 10.1038/s42003-023-05451-4

Experimental method

ELECTRON MICROSCOPY (2.88 Å)