6S3A

Coxsackie B3 2C protein in complex with S-Fluoxetine

Summary for 6S3A

Entry DOI	10.2210/pdb6s3a/pdb
Descriptor	2C protein, (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, ZINC ION, ... (5 entities in total)
Functional Keywords	2c, enterovirus, helicase, atpase, complex, antiviral, porzac, fluoxetine, repurposing, coxsackievirus, viral protein
Biological source	Coxsackievirus B3
Total number of polymer chains	1
Total formula weight	24173.55
Authors	El Kazzi, P.,Papageorgiou, N.,Ferron, F.P.,Bauer, L.,van Kuppeveld, F.,Coutard, B. (deposition date: 2019-06-24, release date: 2021-01-13, Last modification date: 2022-06-01)
Primary citation	Hurdiss, D.L.,El Kazzi, P.,Bauer, L.,Papageorgiou, N.,Ferron, F.P.,Donselaar, T.,van Vliet, A.L.W.,Shamorkina, T.M.,Snijder, J.,Canard, B.,Decroly, E.,Brancale, A.,Zeev-Ben-Mordehai, T.,Forster, F.,van Kuppeveld, F.J.M.,Coutard, B. Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex. Sci Adv, 8:eabj7615-eabj7615, 2022 Cited by PubMed: 34985963 DOI: 10.1126/sciadv.abj7615 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation