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6TCI
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BU of 6tci by Molmil
The crystal structure of SleB N-terminal domain
Descriptor: Spore cortex-lytic enzyme
Authors:Chirgadze, D.Y, Hardwick, S.W, Christie, G.
Deposit date:2019-11-06
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The crystal structure of SleB N-terminal domain
To Be Published
1NK1
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BU of 1nk1 by Molmil
NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION
Descriptor: PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR)
Authors:Chirgadze, D.Y, Hepple, J.P, Zhou, H, Byrd, R.A, Blundell, T.L, Gherardi, E.
Deposit date:1998-08-20
Release date:1999-01-13
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nat.Struct.Biol., 6, 1999
1U41
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BU of 1u41 by Molmil
Crystal structure of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3Y
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BU of 1u3y by Molmil
Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-22
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U42
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BU of 1u42 by Molmil
Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3Z
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BU of 1u3z by Molmil
Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3J
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BU of 1u3j by Molmil
Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-22
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U36
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BU of 1u36 by Molmil
Crystal structure of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor
Descriptor: Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M.
Deposit date:2004-07-21
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
5JIP
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BU of 5jip by Molmil
Crystal structure of the Clostridium perfringens spore cortex lytic enzyme SleM
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cortical-lytic enzyme, MAGNESIUM ION
Authors:Chirgadze, D.Y, Christie, G, Ustok, F.I, Al-Riyami, B, Stott, K.
Deposit date:2016-04-22
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination.
Proteins, 84, 2016
3KX8
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BU of 3kx8 by Molmil
Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK
Descriptor: fluoroacetyl-CoA thioesterase
Authors:Chirgadze, D.Y, Dias, M.V.B, Huang, F, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L.
Deposit date:2009-12-02
Release date:2010-04-28
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010
3G04
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BU of 3g04 by Molmil
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, ...
Authors:Sanders, J, Chirgadze, D.Y, Sanders, P, Baker, S, Sullivan, A, Bhardwaja, A, Bolton, J, Reeve, M, Nakatake, N, Evans, M, Richards, T, Powell, M, Miguel, R.N, Blundell, T.L, Furmaniak, J, Smith, B.R.
Deposit date:2009-01-27
Release date:2009-08-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
8B0J
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BU of 8b0j by Molmil
CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis
Descriptor: GlmZ small RNA, RNase adapter protein RapZ, Ribonuclease E
Authors:Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F.
Deposit date:2022-09-07
Release date:2022-10-05
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis.
Embo J., 42, 2023
8B0I
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BU of 8b0i by Molmil
CryoEM structure of bacterial RapZ.GlmZ complex central to the control of cell envelope biogenesis
Descriptor: GlmZ small regulatory RNA, RNase adapter protein RapZ
Authors:Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F.
Deposit date:2022-09-07
Release date:2022-10-05
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (4.28 Å)
Cite:Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis.
Embo J., 42, 2023
8PET
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BU of 8pet by Molmil
Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Sente, A, Malinauskas, T, Naydenova, K, Hardwick, S.W, Chirgadze, D.Y, Aricescu, A.R.
Deposit date:2023-06-14
Release date:2025-07-02
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Subunit abundance shapes GABAA receptor stoichiometry
To Be Published
6ZFP
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BU of 6zfp by Molmil
Cryo-EM structure of DNA-PKcs (State 2)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-17
Release date:2020-10-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHE
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BU of 6zhe by Molmil
Cryo-EM structure of DNA-PK dimer
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-23
Release date:2020-10-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (7.24 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH2
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BU of 6zh2 by Molmil
Cryo-EM structure of DNA-PKcs (State 1)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-20
Release date:2020-10-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH4
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BU of 6zh4 by Molmil
Cryo-EM structure of DNA-PKcs (State 3)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-20
Release date:2020-10-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH6
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BU of 6zh6 by Molmil
Cryo-EM structure of DNA-PKcs:Ku80ct194
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
3COW
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BU of 3cow by Molmil
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2
Descriptor: 5'-O-{[(2R)-2-hydroxy-3,3-dimethylbutanoyl]sulfamoyl}adenosine, ETHANOL, GLYCEROL, ...
Authors:Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C.
Deposit date:2008-03-29
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9, 2008
6XTY
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BU of 6xty by Molmil
CryoEM structure of human CMG bound to AND-1 (CMGA)
Descriptor: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W.
Deposit date:2020-01-16
Release date:2020-05-27
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (6.77 Å)
Cite:CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
2J66
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BU of 2j66 by Molmil
Structural characterisation of BtrK decarboxylase from butirosin biosynthesis
Descriptor: 1,2-ETHANEDIOL, BTRK, PYRIDOXAL-5'-PHOSPHATE
Authors:Popovic, B, Li, Y, Chirgadze, D.Y, Blundell, T.L, Spencer, J.B.
Deposit date:2006-09-26
Release date:2006-09-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Characterisation of Btrk Decarboxylase from Bacillus Circulans Butirosin Biosynthesis
To be Published
7ZYG
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BU of 7zyg by Molmil
CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
Descriptor: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-24
Release date:2023-06-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
1URF
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BU of 1urf by Molmil
HR1b domain from PRK1
Descriptor: PROTEIN KINASE C-LIKE 1
Authors:Owen, D, Lowe, P.N, Nietlispach, D, Brosnan, C.E, Chirgadze, D.Y, Parker, P.J, Blundell, T.L, Mott, H.R.
Deposit date:2003-10-29
Release date:2003-11-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
3E4R
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BU of 3e4r by Molmil
Crystal structure of the alkanesulfonate binding protein (SsuA) from the phytopathogenic bacteria Xanthomonas axonopodis pv. citri bound to HEPES
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Nitrate transport protein
Authors:Balan, A, Araujo, F.T, Sanches, M, Chirgadze, D.Y, Blundell, T.B, Barbosa, J.A.R.G.
Deposit date:2008-08-12
Release date:2008-09-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of the alkanesulfonate binding protein (SsuA) from the phytopathogenic bacteria Xanthomonas axonopodis pv. citri bound to HEPES
To be Published

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