Author results

1NK1
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NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION
Descriptor:PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR)
Authors:Chirgadze, D.Y., Hepple, J.P., Zhou, H., Byrd, R.A., Blundell, T.L., Gherardi, E.
Deposit date:1998-08-20
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nat.Struct.Biol., 6, 1999
1U36
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CRYSTAL STRUCTURE OF WLAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-21
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3J
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CRYSTAL STRUCTURE OF MLAV MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-22
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3Y
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CRYSTAL STRUCTURE OF ILAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-22
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U3Z
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CRYSTAL STRUCTURE OF MLAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U41
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CRYSTAL STRUCTURE OF YLGV MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
1U42
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CRYSTAL STRUCTURE OF MLAM MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR
Descriptor:Nuclear factor NF-kappa-B p105 subunit
Authors:Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M.
Deposit date:2004-07-23
Release date:2004-08-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
3KX8
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STRUCTURAL BASIS OF THE ACTIVITY AND SUBSTRATE SPECIFICITY OF THE FLUOROACETYL-COA THIOESTERASE FLK
Descriptor:fluoroacetyl-CoA thioesterase
Authors:Chirgadze, D.Y., Dias, M.V.B., Huang, F., Tosin, M., Spiteller, D., Valentine, E.F., Leadlay, P.F., Spencer, J.B., Blundell, T.L.
Deposit date:2009-12-02
Release date:2010-04-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010
5JIP
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CRYSTAL STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS SPORE CORTEX LYTIC ENZYME SLEM
Descriptor:Cortical-lytic enzyme, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION
Authors:Chirgadze, D.Y., Christie, G., Ustok, F.I., Al-Riyami, B., Stott, K.
Deposit date:2016-04-22
Release date:2016-08-10
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination.
Proteins, 84, 2016
3G04
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CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A THYROID-STIMULATING AUTOANTIBODY
Descriptor:HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ...
Authors:Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R.
Deposit date:2009-01-27
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
3MKP
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CRYSTAL STRUCTURE OF 1K1 MUTANT OF HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR FRAGMENT NK1 IN COMPLEX WITH HEPARIN
Descriptor:Hepatocyte growth factor, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Gherardi, E., Chirgadze, D.Y., Blundell, T.L.
Deposit date:2010-04-15
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration
To be Published
1GMN
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CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.
Deposit date:2001-09-19
Release date:2001-10-02
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
1GMO
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CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.
Deposit date:2001-09-20
Release date:2001-10-02
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
1GP9
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A NEW CRYSTAL FORM OF THE NK1 SPLICE VARIANT OF HGF/SF DEMONSTRATES EXTENSIVE HINGE MOVEMENT AND SUGGESTS THAT THE NK1 DIMER ORIGINATES BY DOMAIN SWAPPING
Descriptor:HEPATOCYTE GROWTH FACTOR, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Watanabe, K., Chirgadze, D.Y., Lietha, D., Gherardi, E., Blundell, T.L.
Deposit date:2001-10-31
Release date:2001-11-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping
J.Mol.Biol., 319, 2002
1PPY
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NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase precursor, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-17
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQE
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S25A MUTANT OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQF
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GLYCINE 24 TO SERINE MUTATION OF ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PQH
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SERINE 25 TO THREONINE MUTATION OF ASPARTATE DECARBOXYLASE
Descriptor:Aspartate 1-decarboxylase, SODIUM ION, MALONIC ACID
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-18
Release date:2003-11-18
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PT0
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UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH AN ALANINE INSERTION AT POSITION 26
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-22
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PT1
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UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH HISTIDINE 11 MUTATED TO ALANINE
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-06-22
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PYQ
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UNPROCESSED ASPARTATE DECARBOXYLASE MUTANT, WITH ALANINE INSERTED AT POSITION 24
Descriptor:Aspartate 1-decarboxylase, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-07-09
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PYU
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PROCESSED ASPARTATE DECARBOXYLASE MUTANT WITH SER25 MUTATED TO CYS
Descriptor:Aspartate 1-decarboxylase beta chain, Aspartate 1-decarboxylase alfa chain, SULFATE ION
Authors:Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L.
Deposit date:2003-07-09
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1URF
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HR1B DOMAIN FROM PRK1
Descriptor:PROTEIN KINASE C-LIKE 1
Authors:Owen, D., Lowe, P.N., Nietlispach, D., Brosnan, C.E., Chirgadze, D.Y., Parker, P.J., Blundell, T.L., Mott, H.R.
Deposit date:2003-10-29
Release date:2003-11-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
1YYH
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CRYSTAL STRUCTURE OF THE HUMAN NOTCH 1 ANKYRIN DOMAIN
Descriptor:Notch 1, ankyrin domain
Authors:Ehebauer, M.T., Chirgadze, D.Y., Hayward, P., Martinez-Arias, A., Blundell, T.L.
Deposit date:2005-02-25
Release date:2005-08-16
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:High-resolution crystal structure of the human Notch 1 ankyrin domain
Biochem.J., 392, 2005
1Z56
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CO-CRYSTAL STRUCTURE OF LIF1P-LIG4P
Descriptor:Ligase interacting factor 1, DNA ligase IV
Authors:Dore, A.S., Furnham, N., Davies, O.R., Sibanda, B.L., Chirgadze, D.Y., Jackson, S.P., Pellegrini, L., Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006