1NK1 | | NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION | | Descriptor: | PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR) | | Authors: | Chirgadze, D.Y., Hepple, J.P., Zhou, H., Byrd, R.A., Blundell, T.L., Gherardi, E. | | Deposit date: | 1998-08-20 | | Release date: | 1999-01-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nat.Struct.Biol., 6, 1999
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1U36 | | CRYSTAL STRUCTURE OF WLAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-21 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3J | | CRYSTAL STRUCTURE OF MLAV MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-22 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3Y | | CRYSTAL STRUCTURE OF ILAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-22 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3Z | | CRYSTAL STRUCTURE OF MLAC MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-23 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U41 | | CRYSTAL STRUCTURE OF YLGV MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-23 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U42 | | CRYSTAL STRUCTURE OF MLAM MUTANT OF DIMERISATION DOMAIN OF NF-KB P50 TRANSCRIPTION FACTOR | | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | | Authors: | Chirgadze, D.Y., Demydchuk, M., Becker, M., Moran, S., Paoli, M. | | Deposit date: | 2004-07-23 | | Release date: | 2004-08-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (2.699 Å) | | Cite: | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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3KX8 | | STRUCTURAL BASIS OF THE ACTIVITY AND SUBSTRATE SPECIFICITY OF THE FLUOROACETYL-COA THIOESTERASE FLK | | Descriptor: | fluoroacetyl-CoA thioesterase | | Authors: | Chirgadze, D.Y., Dias, M.V.B., Huang, F., Tosin, M., Spiteller, D., Valentine, E.F., Leadlay, P.F., Spencer, J.B., Blundell, T.L. | | Deposit date: | 2009-12-02 | | Release date: | 2010-04-28 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010
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5JIP | | CRYSTAL STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS SPORE CORTEX LYTIC ENZYME SLEM | | Descriptor: | Cortical-lytic enzyme, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION | | Authors: | Chirgadze, D.Y., Christie, G., Ustok, F.I., Al-Riyami, B., Stott, K. | | Deposit date: | 2016-04-22 | | Release date: | 2016-08-10 | | Last modified: | 2016-11-02 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination.
Proteins, 84, 2016
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3G04 | | CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A THYROID-STIMULATING AUTOANTIBODY | | Descriptor: | HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ... | | Authors: | Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R. | | Deposit date: | 2009-01-27 | | Release date: | 2009-08-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
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3MKP | |
1GMN | | CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | | Descriptor: | HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ... | | Authors: | Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E. | | Deposit date: | 2001-09-19 | | Release date: | 2001-10-02 | | Last modified: | 2017-07-12 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
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1GMO | | CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | | Descriptor: | HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ... | | Authors: | Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E. | | Deposit date: | 2001-09-20 | | Release date: | 2001-10-02 | | Last modified: | 2017-07-12 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
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1GP9 | | A NEW CRYSTAL FORM OF THE NK1 SPLICE VARIANT OF HGF/SF DEMONSTRATES EXTENSIVE HINGE MOVEMENT AND SUGGESTS THAT THE NK1 DIMER ORIGINATES BY DOMAIN SWAPPING | | Descriptor: | HEPATOCYTE GROWTH FACTOR, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | | Authors: | Watanabe, K., Chirgadze, D.Y., Lietha, D., Gherardi, E., Blundell, T.L. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-19 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping
J.Mol.Biol., 319, 2002
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1PPY | | NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE | | Descriptor: | Aspartate 1-decarboxylase precursor, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-17 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PQE | | S25A MUTANT OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE | | Descriptor: | Aspartate 1-decarboxylase | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-18 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PQF | | GLYCINE 24 TO SERINE MUTATION OF ASPARTATE DECARBOXYLASE | | Descriptor: | Aspartate 1-decarboxylase, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-18 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PQH | | SERINE 25 TO THREONINE MUTATION OF ASPARTATE DECARBOXYLASE | | Descriptor: | Aspartate 1-decarboxylase, SODIUM ION, MALONIC ACID | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-18 | | Release date: | 2003-11-18 | | Last modified: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PT0 | | UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH AN ALANINE INSERTION AT POSITION 26 | | Descriptor: | Aspartate 1-decarboxylase, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-22 | | Release date: | 2003-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PT1 | | UNPROCESSED PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE WITH HISTIDINE 11 MUTATED TO ALANINE | | Descriptor: | Aspartate 1-decarboxylase, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-06-22 | | Release date: | 2003-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PYQ | | UNPROCESSED ASPARTATE DECARBOXYLASE MUTANT, WITH ALANINE INSERTED AT POSITION 24 | | Descriptor: | Aspartate 1-decarboxylase, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-07-09 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1PYU | | PROCESSED ASPARTATE DECARBOXYLASE MUTANT WITH SER25 MUTATED TO CYS | | Descriptor: | Aspartate 1-decarboxylase beta chain, Aspartate 1-decarboxylase alfa chain, SULFATE ION | | Authors: | Schmitzberger, F., Kilkenny, M.L., Lobley, C.M.C., Webb, M.E., Vinkovic, M., Matak-Vinkovic, D., Witty, M., Chirgadze, D.Y., Smith, A.G., Abell, C., Blundell, T.L. | | Deposit date: | 2003-07-09 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
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1URF | | HR1B DOMAIN FROM PRK1 | | Descriptor: | PROTEIN KINASE C-LIKE 1 | | Authors: | Owen, D., Lowe, P.N., Nietlispach, D., Brosnan, C.E., Chirgadze, D.Y., Parker, P.J., Blundell, T.L., Mott, H.R. | | Deposit date: | 2003-10-29 | | Release date: | 2003-11-06 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
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1YYH | | CRYSTAL STRUCTURE OF THE HUMAN NOTCH 1 ANKYRIN DOMAIN | | Descriptor: | Notch 1, ankyrin domain | | Authors: | Ehebauer, M.T., Chirgadze, D.Y., Hayward, P., Martinez-Arias, A., Blundell, T.L. | | Deposit date: | 2005-02-25 | | Release date: | 2005-08-16 | | Last modified: | 2018-07-18 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | High-resolution crystal structure of the human Notch 1 ankyrin domain
Biochem.J., 392, 2005
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1Z56 | | CO-CRYSTAL STRUCTURE OF LIF1P-LIG4P | | Descriptor: | Ligase interacting factor 1, DNA ligase IV | | Authors: | Dore, A.S., Furnham, N., Davies, O.R., Sibanda, B.L., Chirgadze, D.Y., Jackson, S.P., Pellegrini, L., Blundell, T.L. | | Deposit date: | 2005-03-17 | | Release date: | 2006-01-31 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (3.92 Å) | | Cite: | Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
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