8PET

Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1

Summary for 8PET

• Entry DOI: 10.2210/pdb8pet/pdb
• EMDB information: 17636
• Descriptor: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Nanobody Nb25, ... (10 entities in total)
• Functional Keywords: neurotransmitter receptor, pentameric ligand-gated ion channel, type-a gaba receptor, gaba-a receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 300537.53

Authors

Sente, A.,Malinauskas, T.,Naydenova, K.,Hardwick, S.W.,Chirgadze, D.Y.,Aricescu, A.R. (deposition date: 2023-06-14, release date: 2025-07-02)

• Primary citation: Sente, A.,Malinauskas, T.,Naydenova, K.,Hardwick, S.W.,Chirgadze, D.Y.,Aricescu, A.R.; Subunit abundance shapes GABAA receptor stoichiometry; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)