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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8PET

Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004890molecular_functionGABA-A receptor activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0008503molecular_functionbenzodiazepine receptor activity
A0016917molecular_functionGABA receptor activity
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032590cellular_componentdendrite membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0038023molecular_functionsignaling receptor activity
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0051932biological_processsynaptic transmission, GABAergic
A0060078biological_processregulation of postsynaptic membrane potential
A0098794cellular_componentpostsynapse
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A0160001biological_processextrasynaptic signaling via GABA
A1902476biological_processchloride transmembrane transport
A1902710cellular_componentGABA receptor complex
A1902711cellular_componentGABA-A receptor complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904862biological_processinhibitory synapse assembly
C0004890molecular_functionGABA-A receptor activity
C0005254molecular_functionchloride channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0008503molecular_functionbenzodiazepine receptor activity
C0016917molecular_functionGABA receptor activity
C0022851molecular_functionGABA-gated chloride ion channel activity
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0032590cellular_componentdendrite membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034707cellular_componentchloride channel complex
C0038023molecular_functionsignaling receptor activity
C0043197cellular_componentdendritic spine
C0045211cellular_componentpostsynaptic membrane
C0051932biological_processsynaptic transmission, GABAergic
C0060078biological_processregulation of postsynaptic membrane potential
C0098794cellular_componentpostsynapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C0160001biological_processextrasynaptic signaling via GABA
C1902476biological_processchloride transmembrane transport
C1902710cellular_componentGABA receptor complex
C1902711cellular_componentGABA-A receptor complex
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMhLedFPmDahaC
ChainResidueDetails
ACYS139-CYS153
BCYS136-CYS150
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues162
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30266951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues255
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues9
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues33
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues9
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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