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1Z9E
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BU of 1z9e by Molmil
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Descriptor: PC4 and SFRS1 interacting protein 2
Authors:Cherepanov, P, Sun, Z.-Y.J, Rahman, S, Maertens, G, Wagner, G, Engelman, A.
Deposit date:2005-04-01
Release date:2005-05-17
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Nat.Struct.Mol.Biol., 12, 2005
2B4J
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BU of 2b4j by Molmil
Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
Descriptor: GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ...
Authors:Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A.
Deposit date:2005-09-24
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
6GX9
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BU of 6gx9 by Molmil
Crystal structure of the TNPO3 - CPSF6 RSLD complex
Descriptor: BENZAMIDINE, BICINE, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Cherepanov, P, Cook, N.
Deposit date:2018-06-26
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Nucleic Acids Res., 47, 2019
6RWO
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BU of 6rwo by Molmil
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWL
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BU of 6rwl by Molmil
SIVrcm intasome
Descriptor: DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), Pol protein, ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWM
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BU of 6rwm by Molmil
SIVrcm intasome in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWN
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BU of 6rwn by Molmil
SIVrcm intasome in complex with dolutegravir
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
5FRO
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BU of 5fro by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f)
Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2015-12-18
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
5M0R
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BU of 5m0r by Molmil
Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex
Descriptor: integrase, tDNA, vDNA, ...
Authors:Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2016-10-05
Release date:2017-01-18
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
7B62
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BU of 7b62 by Molmil
Crystal structure of SARS-CoV-2 spike protein N-terminal domain in complex with biliverdin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, DI(HYDROXYETHYL)ETHER, ...
Authors:Pye, V.E, Rosa, A, Roustan, C, Cherepanov, P.
Deposit date:2020-12-07
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
8POE
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BU of 8poe by Molmil
Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied
Descriptor: Autophagy-related protein 9B
Authors:Chiduza, G.N, Pye, V.E, Tooze, S.A, Cherepanov, P.
Deposit date:2023-07-04
Release date:2023-11-15
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.
Autophagy, 20, 2024
5MEC
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BU of 5mec by Molmil
Crystal structure of yeast Cdt1 middle domain (residues 294-433)
Descriptor: Cell division cycle protein CDT1
Authors:Pye, V.E, Frigola, J, Diffley, J.F.X, Cherepanov, P.
Deposit date:2016-11-14
Release date:2017-05-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Cdt1 stabilizes an open MCM ring for helicase loading.
Nat Commun, 8, 2017
5LLJ
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BU of 5llj by Molmil
Maedi-Visna virus (MVV) integrase C-terminal domain (residues 220-276)
Descriptor: CHLORIDE ION, Integrase
Authors:Pye, V.E, Maskell, D.P, Cherepanov, P.
Deposit date:2016-07-27
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
6YA6
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BU of 6ya6 by Molmil
Minimal construct of Cdc7-Dbf4 bound to XL413
Descriptor: 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, BORIC ACID, CHLORIDE ION, ...
Authors:Dick, S.D, Cherepanov, P.
Deposit date:2020-03-11
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
Structure, 28, 2020
8CBR
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BU of 8cbr by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BDM-2
Descriptor: (2S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-chromen-6-yl)-6-methyl-phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Singer, M.R, Pye, V.E, Yu, Z, Cherepanov, P.
Deposit date:2023-01-25
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
8CBU
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BU of 8cbu by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT884
Descriptor: (2S)-2-[3-cyclopropyl-6-methyl-2-(5-methyl-3,4-dihydro-2H-chromen-6-yl)phenyl]-2-cyclopropyloxy-ethanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Singer, M.R, Pye, V.E, Yu, Z, Cherepanov, P.
Deposit date:2023-01-25
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
8CBV
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BU of 8cbv by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT916
Descriptor: (2~{S})-2-[3-cyclopropyl-2-(8-fluoranyl-5-methyl-3,4-dihydro-2~{H}-chromen-6-yl)-6-methyl-phenyl]-2-cyclopropyloxy-ethanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Singer, M.R, Pye, V.E, Yu, Z, Cherepanov, P.
Deposit date:2023-01-25
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
8CBT
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BU of 8cbt by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT872
Descriptor: (2~{S})-2-[3-cyclopropyl-2-(3,4-dihydro-2~{H}-chromen-6-yl)-6-methyl-phenyl]-2-cyclopropyloxy-ethanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Singer, M.R, Pye, V.E, Yu, Z, Cherepanov, P.
Deposit date:2023-01-25
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
8CBS
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BU of 8cbs by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT871
Descriptor: (2~{S})-2-[3-cyclopropyl-6-methyl-2-(5-methyl-3,4-dihydro-2~{H}-chromen-6-yl)phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Singer, M.R, Pye, V.E, Yu, Z, Cherepanov, P.
Deposit date:2023-01-25
Release date:2023-06-07
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
5FRM
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BU of 5frm by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2015-12-18
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
3HPH
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BU of 3hph by Molmil
Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD
Descriptor: GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ...
Authors:Hare, S, Wang, J, Cherepanov, P.
Deposit date:2009-06-04
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis for functional tetramerization of lentiviral integrase
Plos Pathog., 5, 2009
7Z1Z
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BU of 7z1z by Molmil
MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution
Descriptor: DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ...
Authors:Pye, V.E, Ballandras-Colas, A, Cherepanov, P.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
7ZBU
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BU of 7zbu by Molmil
CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, P008_60 antibody, ...
Authors:Rosa, A, Pye, V.E, Cronin, N, Cherepanov, P.
Deposit date:2022-03-24
Release date:2022-08-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination.
Cell Rep, 40, 2022
5T3A
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BU of 5t3a by Molmil
Maedi-Visna virus (MVV) integrase CCD-CTD (residues 60-275)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, integrase
Authors:Cook, N.J, Pye, V.E, Cherepanov, P.
Deposit date:2016-08-25
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
7U32
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BU of 7u32 by Molmil
MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution
Descriptor: CALCIUM ION, DNA EV272, DNA EV273, ...
Authors:Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022

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