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5FRM

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a)

Summary for 5FRM
Entry DOI10.2210/pdb5frm/pdb
Related5FRN 5FRO
DescriptorPFV INTEGRASE, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... (10 entities in total)
Functional Keywordsrecombination, viral protein/dna, protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna- binding, zinc binding, hhcc motif, viral protein, inhibitor, dna-binding protein-dna complex
Biological sourceHUMAN SPUMARETROVIRUS
More
Total number of polymer chains4
Total formula weight101816.19
Authors
Maskell, D.P.,Pye, V.E.,Cherepanov, P. (deposition date: 2015-12-18, release date: 2016-02-17, Last modification date: 2024-01-10)
Primary citationZhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.J.
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11:1074-, 2016
Cited by
PubMed: 26808478
DOI: 10.1021/ACSCHEMBIO.5B00948
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.58 Å)
Structure validation

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