6RWN

SIVrcm intasome in complex with dolutegravir

Summary for 6RWN

• Entry DOI: 10.2210/pdb6rwn/pdb
• EMDB information: 10043
• Descriptor: Pol protein, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), ... (8 entities in total)
• Functional Keywords: retroviral integrase, lentivirus, strand transfer inhibior, protein-dna complex, recombination
• Biological source: Simian immunodeficiency virus; More
• Total number of polymer chains: 16
• Total formula weight: 433033.41

Authors

Cherepanov, P.,Nans, A.,Cook, N. (deposition date: 2019-06-05, release date: 2020-02-05, Last modification date: 2022-03-30)

• Primary citation: Cook, N.J.,Li, W.,Berta, D.,Badaoui, M.,Ballandras-Colas, A.,Nans, A.,Kotecha, A.,Rosta, E.,Engelman, A.N.,Cherepanov, P.; Structural basis of second-generation HIV integrase inhibitor action and viral resistance.; Science, 367:806-810, 2020; PubMed: 32001525; DOI: 10.1126/science.aay4919

Experimental method

ELECTRON MICROSCOPY (3.1 Å)