6RWN
SIVrcm intasome in complex with dolutegravir
Summary for 6RWN
Entry DOI | 10.2210/pdb6rwn/pdb |
EMDB information | 10043 |
Descriptor | Pol protein, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), ... (8 entities in total) |
Functional Keywords | retroviral integrase, lentivirus, strand transfer inhibior, protein-dna complex, recombination |
Biological source | Simian immunodeficiency virus More |
Total number of polymer chains | 16 |
Total formula weight | 433033.41 |
Authors | Cherepanov, P.,Nans, A.,Cook, N. (deposition date: 2019-06-05, release date: 2020-02-05, Last modification date: 2024-07-10) |
Primary citation | Cook, N.J.,Li, W.,Berta, D.,Badaoui, M.,Ballandras-Colas, A.,Nans, A.,Kotecha, A.,Rosta, E.,Engelman, A.N.,Cherepanov, P. Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science, 367:806-810, 2020 Cited by PubMed: 32001525DOI: 10.1126/science.aay4919 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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