6RWN

SIVrcm intasome in complex with dolutegravir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E, F, G... (A, E, N, L, K...)	Pol protein	polymer	290	32732.2	12	UniProt (E1ANT8) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552)	Simian immunodeficiency virus
2	B, J (Q, S)	DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3')	polymer	33	10134.5	2		Simian immunodeficiency virus
3	C, K (W, T)	DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3')	polymer	30	9224.0	2		Simian immunodeficiency virus
4	DA, EA, FA, Q, V... (M, C, B, A, E...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
5	R, Z (A, I)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	AA, S (I, A)	(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide	non-polymer		419.4	2	Chemie (DLU)
7	BA, CA, T, U (I, A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
8	GA, HA (A, I)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A, E, N, L, K, J, I, M, F, D, C, B: 1 - 289 (UniProt: E1ANT8)

PDB	External Database	Details
Gly 0	-	expression tag
Asp 119	Ala 853	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	431503.3
Non-Polymers*	Number of molecules	16
	Total formula weight	1530.2
All*	Total formula weight	433033.4

*Water molecules are not included.