Author results

1JXH
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4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE KINASE FROM SALMONELLA TYPHIMURIUM
Descriptor:PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION
Authors:Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E.
Deposit date:2001-09-07
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure, 10, 2002
1JXI
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4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE KINASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE
Descriptor:PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION, 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE
Authors:Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E.
Deposit date:2001-09-07
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure, 10, 2002
4GJH
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CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF5
Descriptor:TNF receptor-associated factor 5
Authors:Zhang, P., Reichardt, A., Liang, H., Wang, Y., Cheng, D., Aliyari, R., Cheng, G., Liu, Y.
Deposit date:2012-08-09
Release date:2012-11-28
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
5GZN
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody Heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2016-12-28
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
5GZO
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2017-01-18
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
1KZZ
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DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
Descriptor:TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator
Authors:Li, C., Ni, C.-Z., Havert, M.L., Cabezas, E., He, J., Kaiser, D., Reed, J.C., Satterthwait, A.C., Cheng, G., Ely, K.R.
Deposit date:2002-02-08
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Structure, 10, 2002
1L0A
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DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3
Descriptor:TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator
Authors:Li, C., Ni, C.-Z., Havert, M.L., Cabezas, E., He, J., Kaiser, D., Reed, J.C., Satterthwait, A.C., Cheng, G., Ely, K.R.
Deposit date:2002-02-08
Release date:2002-04-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Downstream regulator TANK binds to the CD40 recognition site on TRAF3.
Structure, 10, 2002
4EFO
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CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OF HUMAN TBK1
Descriptor:Serine/threonine-protein kinase TBK1
Authors:Li, J., Li, J., Miyahira, A., Sun, J., Liu, Y., Cheng, G., Liang, H.
Deposit date:2012-03-30
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Crystal structure of the ubiquitin-like domain of human TBK1.
Protein Cell, 3, 2012
4J0U
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CRYSTAL STRUCTURE OF IFIT5/ISG58
Descriptor:Interferon-induced protein with tetratricopeptide repeats 5
Authors:Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
Deposit date:2013-01-31
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Crystal Structure of IFIT5
To be Published
4J1G
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LEANYER ORTHOBUNYAVIRUS NUCLEOPROTEIN-SSRNA COMPLEX
Descriptor:Nucleocapsid, RNA (45-MER)
Authors:Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., Ouyang, S., Cheng, G., Liu, Z.J.
Deposit date:2013-02-01
Release date:2013-04-10
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4J1J
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LEANYER ORTHOBUNYAVIRUS NUCLEOPROTEIN-SSDNA COMPLEX
Descriptor:Nucleocapsid, DNA (5'-D(P*AP*CP*CP*AP*AP*AP*CP*AP*AP*CP*CP*CP*AP*CP*CP*CP*A)-3')
Authors:Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., Ouyang, S., Cheng, G., Liu, Z.J.
Deposit date:2013-02-01
Release date:2013-04-10
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JBJ
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STRUCTURAL MIMICRY FOR FUNCTIONAL ANTAGONISM
Descriptor:Interferon-activable protein 202
Authors:Ru, H., Ni, X., Ma, F., Zhao, L., Ding, W., Hung, L.-W., Shaw, N., Cheng, G., Liu, Z.-J.
Deposit date:2013-02-19
Release date:2013-06-26
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Structural basis for termination of AIM2-mediated signaling by p202
Cell Res., 23, 2013
4JBK
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MOLECULAR BASIS FOR ABROGATION OF ACTIVATION OF PRO-INFLAMMATORY CYTOKINES
Descriptor:Interferon-activable protein 202, DNA (5'-D(P*GP*GP*AP*AP*TP*TP*AP*TP*AP*AP*TP*TP*CP*C)-3')
Authors:Ru, H., Ni, X., Crowley, C., Zhao, L., Ding, W., Hung, L.-W., Shaw, N., Cheng, G., Liu, Z.-J.
Deposit date:2013-02-19
Release date:2013-06-26
Method:X-RAY DIFFRACTION (2.963 Å)
Cite:Structural basis for termination of AIM2-mediated signaling by p202
Cell Res., 23, 2013
4JBM
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STRUCTURE OF MURINE DNA BINDING PROTEIN BOUND WITH DS DNA
Descriptor:Interferon-inducible protein AIM2, DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3')
Authors:Ru, H., Ni, X., Crowley, C., Zhao, L., Ding, W., Hung, L.-W., Shaw, N., Cheng, G., Liu, Z.-J.
Deposit date:2013-02-19
Release date:2013-06-26
Method:X-RAY DIFFRACTION (2.218 Å)
Cite:Structural basis for termination of AIM2-mediated signaling by p202
Cell Res., 23, 2013
4GHU
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CRYSTAL STRUCTURE OF TRAF3/CARDIF
Descriptor:TNF receptor-associated factor 3, Mitochondrial antiviral-signaling protein
Authors:Zhang, P.
Deposit date:2012-08-08
Release date:2012-11-28
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
6INF
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A GLYCOSYLTRANSFERASE COMPLEX WITH UDP
Descriptor:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE
Authors:Zhu, X., Yang, T., Naismith, J.H.
Deposit date:2018-10-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6ING
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A COMPLEX STRUCTURE OF H25A MUTANT OF GLYCOSYLTRANSFERASE WITH UDP
Descriptor:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Zhu, X., Naismith, J.H.
Deposit date:2018-10-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6INH
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A GLYCOSYLTRANSFERASE WITH UDP AND THE SUBSTRATE
Descriptor:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, 1-O-[(8alpha,9beta,10alpha,13alpha)-13-(beta-D-glucopyranosyloxy)-18-oxokaur-16-en-18-yl]-beta-D-glucopyranose, ...
Authors:Zhu, X.
Deposit date:2018-10-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6INI
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A GLYCOSYLTRANSFERASE COMPLEX WITH UDP AND THE PRODUCT
Descriptor:UDP-glycosyltransferase 76G1, URIDINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Zhu, X., Yang, T., Naismith, J.H.
Deposit date:2018-10-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
6NZV
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CRYSTAL STRUCTURE OF HCV NS3/4A PROTEASE IN COMPLEX WITH COMPOUND 12
Descriptor:HCV NS3/4A protease, (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, ZINC ION, ...
Authors:Appleby, T.C., Taylor, J.G.
Deposit date:2019-02-14
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg.Med.Chem.Lett., 2019
5GZR
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ZIKA VIRUS E PROTEIN COMPLEXED WITH A NEUTRALIZING ANTIBODY Z23-FAB
Descriptor:structural protein E, strutural protein M, Z23 Fab heavy chain, ...
Authors:Gao, G.G., Shi, Y., Peng, R., Liu, S.
Deposit date:2016-10-01
Release date:2016-11-30
Last modified:2016-12-28
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
2GKW
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KEY CONTACTS PROMOTE RECONGNITO OF BAFF-R BY TRAF3
Descriptor:TNF receptor-associated factor 3, Tumor necrosis factor receptor superfamily member 13C
Authors:Ely, K.R.
Deposit date:2006-04-03
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation.
J.Immunol., 173, 2004
1RF3
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STRUCTURALLY DISTINCT RECOGNITION MOTIFS IN LYMPHOTOXIN-B RECEPTOR AND CD40 FOR TRAF-MEDIATED SIGNALING
Descriptor:TNF receptor associated factor 3, 24-residue peptide from Lymphotoxin-B Receptor
Authors:Li, C., Norris, P.S., Ni, C.Z., Havert, M.L., Chiong, E.M., Tran, B.R., Cabezas, E., Cheng, G., Reed, J.C., Satterthwait, A.C., Ware, C.F., Ely, K.R.
Deposit date:2003-11-07
Release date:2004-07-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.
J.Biol.Chem., 278, 2003
3ANL
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CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH PYRIDIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (pyridin-2-ylmethyl)phosphonic acid
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
3ANM
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CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH 5-PHENYLPYRIDIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, [(5-phenylpyridin-2-yl)methyl]phosphonic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
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