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5ZAN
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CRYSTAL STRUCTURE OF AURORA-A IN COMPLEX WITH A NEW QUINAZOLINE INHIBITOR
Descriptor:Aurora kinase A, 7-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine
Authors:Cheng, B., Lu, G., Zhou, H.
Deposit date:2018-02-07
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Optimization of Novel Quinazolines as Potent and Orally Bioavailable Aurora Kinase Inhibitors
To Be Published
6J71
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HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
Descriptor:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
Authors:Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
Deposit date:2019-01-16
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells
To Be Published
1HP9
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KAPPA-HEFUTOXINS: A NOVEL CLASS OF POTASSIUM CHANNEL TOXINS FROM SCORPION VENOM
Descriptor:kappa-hefutoxin 1
Authors:Srinivasan, K.N., Sivaraja, V., Huys, I., Sasaki, T., Cheng, B., Kumar, T.K.S., Sato, K., Tytgat, J., Yu, C., Brian Chia, C.S., Ranganathan, S., Bowie, J.H., Kini, R.M., Gopalakrishnakone, P.
Deposit date:2000-12-12
Release date:2002-08-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity.
J.Biol.Chem., 277, 2002
3PX7
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CRYSTAL STRUCTURE OF COVALENT COMPLEX OF TOPOISOMERASE 1A WITH SUBSTRATE
Descriptor:DNA topoisomerase, DNA 5'-D(*TP*TP*GP*GP*G)-3', DNA 5'-D(*A*AP*TP*GP*CP*GP*CP*T)-3', ...
Authors:Zhang, Z., Tse-dinh, Y.C., Cheng, B.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of E. coli Topoisomerase I Trapped as Covalent Complex Intermediate with Cleaved DNA
To be Published
5D5H
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TOPOISOMERASE I
Descriptor:DNA topoisomerase 1, SULFATE ION, GLYCEROL, ...
Authors:Tan, K., Cheng, B., Tse-Dinh, Y.C.
Deposit date:2015-08-10
Release date:2015-12-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold.
J.Mol.Biol., 428, 2016
4RUL
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CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI TOPOISOMERASE I IN COMPLEX WITH SSDNA
Descriptor:DNA topoisomerase 1, single strand DNA, ZINC ION, ...
Authors:Tan, K., Chen, B., Tse-Dinh, Y.C.
Deposit date:2014-11-20
Release date:2015-11-04
Last modified:2016-01-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I.
Nucleic Acids Res., 43, 2015
5OEL
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MYCOBACTERIUM TUBERCULOSIS DPRE1 MUTANT Y314C IN COMPLEX WITH TCA1
Descriptor:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate
Authors:Futterer, K., Batt, S.M., Besra, G.S.
Deposit date:2017-07-08
Release date:2018-05-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEP
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MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA481
Descriptor:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ~{N}-[2-(1,3-benzothiazol-2-ylcarbonylamino)-5-fluoranyl-thiophen-3-yl]carbonylcarbamate, ...
Authors:Futterer, K., Batt, S.M., Besra, G.S.
Deposit date:2017-07-09
Release date:2018-05-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEQ
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MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA020
Descriptor:Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[3-(pyrimidin-2-ylcarbamoyl)thiophen-2-yl]-[1,3]thiazolo[4,5-c]pyridine-2-carboxamide, ...
Authors:Futterer, K., Batt, S.M., Besra, G.S.
Deposit date:2017-07-09
Release date:2018-05-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5W0C
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CYTOCHROME P450 (CYP) 2C9 TCA007 INHIBITOR COMPLEX
Descriptor:Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, ethyl {2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate, ...
Authors:Johnson, E.F., Hsu, M.-H.
Deposit date:2017-05-30
Release date:2017-09-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
1KIV
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RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor:APOLIPOPROTEIN A
Authors:Mochalkin, I., Tulinsky, A., Scanu, A.
Deposit date:1998-08-26
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
3KIV
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RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor:APOLIPOPROTEIN, 6-AMINOHEXANOIC ACID
Authors:Mochalkin, I., Tulinsky, A., Scanu, A.
Deposit date:1998-09-08
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
3PWT
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CRYSTAL STRUCTURE OF MUTANT E.COLI TOPOISOMERASE IA
Descriptor:DNA topoisomerase, SULFATE ION
Authors:Zhang, Z., Bokun, C., Tse-Dinh, Y.-C.
Deposit date:2010-12-08
Release date:2010-12-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of mutant E.coli topoisomerase IA
To be Published
4KIV
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RECOMBINANT KRINGLE IV-10/W72R MUTANT OF HUMAN APOLIPOPROTEIN(A)
Descriptor:APOLIPOPROTEIN
Authors:Mochalkin, I., Tulinsky, A., Scanu, A.
Deposit date:1998-08-26
Release date:1999-05-18
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance.
Biochemistry, 38, 1999
5CVC
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STRUCTURE OF MAIZE SERINE RACEMASE
Descriptor:Serine racemase, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Song, Y., Zou, L., Fan, J.
Deposit date:2015-07-26
Release date:2016-03-16
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of maize serine racemase with pyridoxal 5'-phosphate.
Acta Crystallogr.,Sect.F, 72, 2016
5HPG
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STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
Descriptor:PLASMINOGEN
Authors:Tulinsky, A., Mochalkin, I., Castellino, F.J.
Deposit date:1997-09-19
Release date:1998-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Biochemistry, 37, 1998
1I5K
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STRUCTURE AND BINDING DETERMINANTS OF THE RECOMBINANT KRINGLE-2 DOMAIN OF HUMAN PLASMINOGEN TO AN INTERNAL PEPTIDE FROM A GROUP A STREPTOCOCCAL SURFACE PROTEIN
Descriptor:PLASMINOGEN, M PROTEIN
Authors:Rios-Steiner, J.L., Schenone, M., Mochalkin, I., Tulinsky, A., Castellino, F.J.
Deposit date:2001-02-27
Release date:2001-08-01
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein.
J.Mol.Biol., 308, 2001