5OEL

Mycobacterium tuberculosis DprE1 mutant Y314C in complex with TCA1

Summary for 5OEL

• Entry DOI: 10.2210/pdb5oel/pdb
• Related: 4KW5
• Descriptor: Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate, ... (4 entities in total)
• Functional Keywords: fad-containing oxidoreductase decaprenylphosphoarabinose synthesis, oxidoreductase
• Biological source: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
• Cellular location: Periplasm : P9WJF0
• Total number of polymer chains: 2
• Total formula weight: 106281.57

Authors

Futterer, K.,Batt, S.M.,Besra, G.S. (deposition date: 2017-07-08, release date: 2018-05-16, Last modification date: 2024-01-17)

• Primary citation: Liu, R.,Lyu, X.,Batt, S.M.,Hsu, M.H.,Harbut, M.B.,Vilcheze, C.,Cheng, B.,Ajayi, K.,Yang, B.,Yang, Y.,Guo, H.,Lin, C.,Gan, F.,Wang, C.,Franzblau, S.G.,Jacobs, W.R.,Besra, G.S.,Johnson, E.F.,Petrassi, M.,Chatterjee, A.K.,Futterer, K.,Wang, F.; Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.; Angew. Chem. Int. Ed. Engl., 56:13011-13015, 2017; PubMed: 28815830; DOI: 10.1002/anie.201707324

Experimental method

X-RAY DIFFRACTION (2.2 Å)