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6L2P

Threonyl-tRNA synthetase from Salmonella enterica in the apo form

Summary for 6L2P
Entry DOI10.2210/pdb6l2p/pdb
DescriptorThreonine--tRNA ligase, ZINC ION (3 entities in total)
Functional Keywordstrna synthetase, drug target, homodimer, ligase
Biological sourceSalmonella enterica subsp. enterica serovar Cubana str. 76814
Total number of polymer chains2
Total formula weight96059.84
Authors
Guo, J.,Chen, B.,Zhou, H. (deposition date: 2019-10-05, release date: 2020-01-15, Last modification date: 2023-11-22)
Primary citationGuo, J.,Chen, B.,Yu, Y.,Cheng, B.,Cheng, Y.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H.
Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.
Eur.J.Med.Chem., 187:111941-111941, 2019
Cited by
PubMed: 31821989
DOI: 10.1016/j.ejmech.2019.111941
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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