5ZNJ

Crystal structure of a bacterial ProRS with ligands

Summary for 5ZNJ

Entry DOI	10.2210/pdb5znj/pdb
Descriptor	Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (7 entities in total)
Functional Keywords	aminoacyl-trna synthetase, protein biosynthesis, inhibitor, ligase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	65070.22
Authors	Cheng, B.,Yu, Y.,Zhou, H. (deposition date: 2018-04-09, release date: 2019-05-29, Last modification date: 2023-11-29)
Primary citation	Cheng, B.,Cai, Z.,Luo, Z.,Luo, S.,Luo, Z.,Cheng, Y.,Yu, Y.,Guo, J.,Ju, Y.,Gu, Q.,Xu, J.,Jiang, X.,Li, G.,Zhou, H. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem., 65:15840-15855, 2022 Cited by PubMed: 36394909 DOI: 10.1021/acs.jmedchem.2c01496 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation