Author results

6O6M
  • Download 6o6m
  • View 6o6m
Molmil generated image of 6o6m
THE STRUCTURE OF EGTB (CABTHER)
Descriptor:EgtB (Cabther), FE (III) ION, GLYCEROL
Authors:Irani, S., Zhang, Y.
Deposit date:2019-03-07
Release date:2019-07-31
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity
Acs Catalysis, 2019
6O6L
  • Download 6o6l
  • View 6o6l
Molmil generated image of 6o6l
THE STRUCTURE OF EGTB(CABTHER) IN COMPLEX WITH HERCYNINE
Descriptor:EgtB (Cabther), N,N,N-trimethyl-histidine, FE (III) ION
Authors:Irani, S., Zhang, Y.
Deposit date:2019-03-07
Release date:2019-07-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity
Acs Catalysis, 2019
6O2P
  • Download 6o2p
  • View 6o2p
Molmil generated image of 6o2p
COMPLEX OF IVACAFTOR WITH CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)
Descriptor:Cystic fibrosis transmembrane conductance regulator, Unknown Peptide, MAGNESIUM ION, ...
Authors:Liu, F., Zhang, Z., Chen, J., Levit, A., Shoichet, B.
Deposit date:2019-02-24
Release date:2019-06-26
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019
6O1V
  • Download 6o1v
  • View 6o1v
Molmil generated image of 6o1v
COMPLEX OF HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) AND GLPG1837
Descriptor:Cystic fibrosis transmembrane conductance regulator, Unknown Peptide, N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide, ...
Authors:Zhang, Z., Liu, F., Chen, J., Levit, A., Shoichet, B.
Deposit date:2019-02-21
Release date:2019-06-26
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019
6O1B
  • Download 6o1b
  • View 6o1b
Molmil generated image of 6o1b
CRYSTAL STRUCTURE OF THE TIR DOMAIN G601P MUTANT FROM HUMAN SARM1, CRYSTAL FORM 1
Descriptor:Sterile alpha and TIR motif-containing protein 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-18
Release date:2019-09-04
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0W
  • Download 6o0w
  • View 6o0w
Molmil generated image of 6o0w
CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM THE GRAPEVINE DISEASE RESISTANCE PROTEIN RUN1 IN COMPLEX WITH NADP+ AND BIS-TRIS
Descriptor:TIR-NB-LRR type resistance protein RUN1, ADENOSINE-2'-5'-DIPHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0V
  • Download 6o0v
  • View 6o0v
Molmil generated image of 6o0v
CRYSTAL STRUCTURE OF THE TIR DOMAIN G601P MUTANT FROM HUMAN SARM1, CRYSTAL FORM 2
Descriptor:Sterile alpha and TIR motif-containing protein 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0U
  • Download 6o0u
  • View 6o0u
Molmil generated image of 6o0u
CRYSTAL STRUCTURE OF THE TIR DOMAIN H685A MUTANT FROM HUMAN SARM1
Descriptor:Sterile alpha and TIR motif-containing protein 1
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0T
  • Download 6o0t
  • View 6o0t
Molmil generated image of 6o0t
CRYSTAL STRUCTURE OF SELENOMETHIONINE LABELLED TANDEM SAM DOMAINS (L446M:L505M:L523M MUTANT) FROM HUMAN SARM1
Descriptor:Sterile alpha and TIR motif-containing protein 1
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0S
  • Download 6o0s
  • View 6o0s
Molmil generated image of 6o0s
CRYSTAL STRUCTURE OF THE TANDEM SAM DOMAINS FROM HUMAN SARM1
Descriptor:Sterile alpha and TIR motif-containing protein 1
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0R
  • Download 6o0r
  • View 6o0r
Molmil generated image of 6o0r
CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM HUMAN SARM1 IN COMPLEX WITH GLYCEROL
Descriptor:Sterile alpha and TIR motif-containing protein 1, GLYCEROL
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0Q
  • Download 6o0q
  • View 6o0q
Molmil generated image of 6o0q
CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM HUMAN SARM1 IN COMPLEX WITH RIBOSE
Descriptor:Sterile alpha and TIR motif-containing protein 1, BETA-D-RIBOFURANOSYL, CHLORIDE ION
Authors:Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
Deposit date:2019-02-17
Release date:2019-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6NBI
  • Download 6nbi
  • View 6nbi
Molmil generated image of 6nbi
CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBH
  • Download 6nbh
  • View 6nbh
Molmil generated image of 6nbh
CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBF
  • Download 6nbf
  • View 6nbf
Molmil generated image of 6nbf
CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6N4R
  • Download 6n4r
  • View 6n4r
Molmil generated image of 6n4r
CRYOEM STRUCTURE OF NAV1.7 VSD2 (DEACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
Descriptor:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
Authors:Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4Q
  • Download 6n4q
  • View 6n4q
Molmil generated image of 6n4q
CRYOEM STRUCTURE OF NAV1.7 VSD2 (ACTIVED STATE) IN COMPLEX WITH THE GATING MODIFIER TOXIN PROTX2
Descriptor:Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ...
Authors:Xu, H., Rohou, A., Arthur, C.P., Estevez, A., Ciferri, C., Payandeh, J., Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N4I
  • Download 6n4i
  • View 6n4i
Molmil generated image of 6n4i
STRUCTURAL BASIS OF NAV1.7 INHIBITION BY A GATING-MODIFIER SPIDER TOXIN
Descriptor:Nav1.7 VSD2-NavAb channel chimera protein, Beta/omega-theraphotoxin-Tp2a, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Xu, H., Koth, C.M., Payandeh, J.
Deposit date:2018-11-19
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.541 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6MVA
  • Download 6mva
  • View 6mva
Molmil generated image of 6mva
LDHA STRUCTURE IN COMPLEX WITH INHIBITOR 14
Descriptor:L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eigenbrot, C.E., Ultsch, M., Wei, B.
Deposit date:2018-10-24
Release date:2019-10-30
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure-based Optimization of Potent, Cell-Active Hydroxylactam Inhibitors of Lactate Dehydrogenase
To Be Published
6MV8
  • Download 6mv8
  • View 6mv8
Molmil generated image of 6mv8
LDHA STRUCTURE IN COMPLEX WITH INHIBITOR 14
Descriptor:L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Eigenbrot, C.E., Ultsch, M., Wei, B.
Deposit date:2018-10-24
Release date:2019-10-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based Optimization of Potent, Cell-Active Hydroxylactam Inhibitors of Lactate Dehydrogenase
To Be Published
6MSM
  • Download 6msm
  • View 6msm
Molmil generated image of 6msm
PHOSPHORYLATED, ATP-BOUND HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)
Descriptor:Cystic fibrosis transmembrane conductance regulator, Piece of Molecule-1, MAGNESIUM ION, ...
Authors:Zhang, Z., Liu, F., Chen, J.
Deposit date:2018-10-16
Release date:2018-11-21
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular structure of the ATP-bound, phosphorylated human CFTR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7J
  • Download 6m7j
  • View 6m7j
Molmil generated image of 6m7j
MYCOBACTERIUM TUBERCULOSIS RNAP WITH RBPA/US FORK AND CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-20
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6M7G
  • Download 6m7g
  • View 6m7g
Molmil generated image of 6m7g
CRYSTAL STRUCTURE OF ARSN, N-ACETYLTRANSFERASE WITH SUBSTRATE PHOSPHINOTHRICIN FROM PSEUDOMONAS PUTIDA KT2440
Descriptor:Phosphinothricin N-acetyltransferase, PHOSPHINOTHRICIN
Authors:Venkadesh, S., Dheeman, D.S., Yoshinaga, M., Kandavelu, P., Rosen, B.P.
Deposit date:2018-08-20
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.657 Å)
Cite:Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.
Commun Biol, 2, 2019
6K2Q
  • Download 6k2q
  • View 6k2q
Molmil generated image of 6k2q
AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE
Authors:Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y.
Deposit date:2019-05-15
Release date:2019-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
6K0B
  • Download 6k0b
  • View 6k0b
Molmil generated image of 6k0b
CRYO-EM STRUCTURE OF ARCHAEAL RIBONUCLEASE P WITH MATURE TRNA
Descriptor:Ribonuclease P protein component 2, Ribonuclease P protein component 3, Ribonuclease P protein component 1, ...
Authors:Wan, F., Lan, P., Wu, J., Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019