Author results

3CIQ
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A REGULATABLE SWITCH MEDIATES SELF-ASSOCIATION IN AN IMMUNOGLOBULIN FOLD
Descriptor:Beta-2-microglobulin, COPPER (II) ION, L(+)-TARTARIC ACID
Authors:Calabrese, M.F., Eakin, C.M., Wang, J.M., Miranker, A.D.
Deposit date:2008-03-11
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A regulatable switch mediates self-association in an immunoglobulin fold.
Nat.Struct.Mol.Biol., 15, 2008
3RTR
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A RING E3-SUBSTRATE COMPLEX POISED FOR UBIQUITIN-LIKE PROTEIN TRANSFER: STRUCTURAL INSIGHTS INTO CULLIN-RING LIGASES
Descriptor:Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Calabrese, M.F., Scott, D.C., Duda, D.M., Grace, C.R., Kurinov, I., Kriwacki, R.W., Schulman, B.A.
Deposit date:2011-05-03
Release date:2011-07-20
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
4QFG
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STRUCTURE OF AMPK IN COMPLEX WITH STAUROSPORINE INHIBITOR AND IN THE ABSENCE OF A SYNTHETIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2014-05-20
Release date:2014-08-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
Structure, 22, 2014
4QFR
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STRUCTURE OF AMPK IN COMPLEX WITH CL-A769662 ACTIVATOR AND STAUROSPORINE INHIBITOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2014-05-21
Release date:2014-08-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
Structure, 22, 2014
4QFS
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STRUCTURE OF AMPK IN COMPLEX WITH BR2-A769662CORE ACTIVATOR AND STAUROSPORINE INHIBITOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2014-05-21
Release date:2014-08-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.
Structure, 22, 2014
4O1V
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SPOP PROMOTES TUMORIGENESIS BY ACTING AS A KEY REGULATORY HUB IN KIDNEY CANCER
Descriptor:Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Authors:Calabrese, M.F., Watson, E.R., Schulman, B.A.
Deposit date:2013-12-16
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
Cancer Cell, 25, 2014
5T5T
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AMPK BOUND TO ALLOSTERIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2016-08-31
Release date:2017-03-29
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J. Pharmacol. Exp. Ther., 361, 2017
5UFU
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2017-01-05
Release date:2017-05-17
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cell Metab., 25, 2017
6E4T
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4U
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4W
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STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
3IVB
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-08-31
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure 9
To be Published
3IVQ
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-CISBC2
Descriptor:Speckle-type POZ protein, CiSBC2
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-PUCSBC1_PEP1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3MYZ
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PROTEIN INDUCED PHOTOPHYSICAL CHANGES TO THE AMYLOID INDICATOR DYE, THIOFLAVIN T
Descriptor:Beta-2-microglobulin, MERCURY (II) ION, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, ...
Authors:Wolfe, L.S., Calabrese, M.F., Nath, A., Blaho, D.V., Miranker, A.D., Xiong, Y.
Deposit date:2010-05-11
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Protein-induced photophysical changes to the amyloid indicator dye thioflavin T.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MZT
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PROTEIN-INDUCED PHOTOPHYSICAL CHANGES TO THE AMYLOID INDICATOR DYE, THIOFLAVIN T
Descriptor:Beta-2-microglobulin, COPPER (II) ION, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium
Authors:Wolfe, L.S., Calabrese, M.F., Nath, A., Blaho, D.V., Miranker, A.D., Xiong, Y.
Deposit date:2010-05-13
Release date:2010-09-08
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Protein-induced photophysical changes to the amyloid indicator dye thioflavin T.
Proc.Natl.Acad.Sci.USA, 107, 2010
5KQ5
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AMPK BOUND TO ALLOSTERIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2016-07-05
Release date:2016-08-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J.Med.Chem., 59, 2016
3HQH
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, MacroH2A, ZINC ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-06
Release date:2009-10-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQI
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX/BTB/3-BOX-PUCSBC1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQL
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES:SPOPMATHX-PUCSBC1_PEP2
Descriptor:Speckle-type POZ protein, Puckered, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQM
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-CISBC2
Descriptor:Speckle-type POZ protein, Protein cubitus interruptus, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HSV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP2
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Zhuang, M., Schulman, B.A., Miller, D.
Deposit date:2009-06-10
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HTM
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPBTB/3-BOX
Descriptor:Speckle-type POZ protein
Authors:Zhuang, M., Walden, H., Schulman, B.A.
Deposit date:2009-06-11
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HU6
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX/BTB/3-BOX-PUCSBC1
Descriptor:Speckle-type POZ protein, Puckered
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-13
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HVE
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: GIGAXONINBTB/3-BOX
Descriptor:Gigaxonin
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-16
Release date:2009-10-27
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009