8DSF

Structure of cIAP1 with BCCov

Summary for 8DSF

Entry DOI	10.2210/pdb8dsf/pdb
Descriptor	Baculoviral IAP repeat-containing protein 2, ZINC ION, (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide unbound form, ... (4 entities in total)
Functional Keywords	degrader, inhibitor of apoptosis, e3 ligase, apoptosis
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	49962.01
Authors	Schiemer, J.S.,Calabrese, M.F. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2023-10-25)
Primary citation	Schiemer, J.,Maxwell, A.,Horst, R.,Liu, S.,Uccello, D.P.,Borzilleri, K.,Rajamohan, N.,Brown, M.F.,Calabrese, M.F. A covalent BTK ternary complex compatible with targeted protein degradation Nat Commun, 14:1189-, 2023 Cited by DOI: 10.1038/s41467-023-36738-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation