6W74

Structure of cIAP with compound 15

Summary for 6W74

• Entry DOI: 10.2210/pdb6w74/pdb
• Descriptor: Baculoviral IAP repeat-containing protein 2, ZINC ION, 14-{[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-3,6,9,12-tetraoxatetradecan-1-yl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate, ... (4 entities in total)
• Functional Keywords: ciap e3 protac, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 12564.48

Authors

Calabrese, M.F.,Schiemer, J.S. (deposition date: 2020-03-18, release date: 2020-11-18, Last modification date: 2023-10-18)

• Primary citation: Calabrese, M.F.,Schiemer, J.S.,Horst, R.,Meng, Y.,Montgomery, J.,Xu, Y.,Feng, X.,Borzilleri, K.,Uccello, D.P.,Leverett, C.,Brown, S.,Che, Y.,Brown, M.F.,Hayward, M.M.,Gilbert, A.M.,Noe, M.C.; Structural Characterization of BTK:PROTAC:cIAP Ternary Complexes: From Snapshots to Ensembles; Nat.Chem.Biol., 2020

Experimental method

X-RAY DIFFRACTION (2.11 Å)