6W74
Structure of cIAP with compound 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Baculoviral IAP repeat-containing protein 2 | polymer | 99 | 11318.7 | 1 | UniProt (Q13490) Pfam (PF00653) | Homo sapiens (Human) | Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 14-{[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-3,6,9,12-tetraoxatetradecan-1-yl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate | non-polymer | 1180.3 | 1 | Chemie (TKY) | |||
| 4 | D (A) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 260 - 352 (UniProt: Q13490)
| PDB | External Database | Details |
|---|---|---|
| Gly 254 | - | expression tag |
| Ser 255 | - | expression tag |
| Gly 256 | - | expression tag |
| Pro 257 | - | expression tag |
| Gly 258 | - | expression tag |
| Ser 259 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11318.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1245.8 | |
| All* | Total formula weight | 12564.5 |
