9D3E

Cryo-EM structure of CCR6 bound by SQA1 and OXM2

This is a non-PDB format compatible entry.

Summary for 9D3E

• Entry DOI: 10.2210/pdb9d3e/pdb
• EMDB information: 46533
• Descriptor: Human CCR6, anti-BRIL Fab Heavy chain, anti-BRIL Fab Nanobody, ... (7 entities in total)
• Functional Keywords: gpcr, antagonist, ccr6, bril, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 125775.21

Authors

Wasilko, D.J.,Wu, H. (deposition date: 2024-08-09, release date: 2024-09-11)

• Primary citation: Wasilko, D.J.,Gerstenberger, B.S.,Farley, K.A.,Li, W.,Alley, J.,Schnute, M.E.,Unwalla, R.J.,Victorino, J.,Crouse, K.K.,Ding, R.,Sahasrabudhe, P.V.,Vincent, F.,Frisbie, R.K.,Dermenci, A.,Flick, A.,Choi, C.,Chinigo, G.,Mousseau, J.J.,Trujillo, J.I.,Nuhant, P.,Mondal, P.,Lombardo, V.,Lamb, D.,Hogan, B.J.,Minhas, G.S.,Segala, E.,Oswald, C.,Windsor, I.W.,Han, S.,Rappas, M.,Cooke, R.M.,Calabrese, M.F.,Berstein, G.,Thorarensen, A.,Wu, H.; Structural basis for CCR6 modulation by allosteric antagonists.; Nat Commun, 15:7574-7574, 2024; PubMed: 39217154; DOI: 10.1038/s41467-024-52045-7

Experimental method

ELECTRON MICROSCOPY (3.02 Å)