Author results

2VIF
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CRYSTAL STRUCTURE OF SOCS6 SH2 DOMAIN IN COMPLEX WITH A C-KIT PHOSPHOPEPTIDE
分子名称:SUPPRESSOR OF CYTOKINE SIGNALLING 6, MAST/STEM CELL GROWTH FACTOR RECEPTOR, 1,2-ETHANEDIOL
著者Bullock, A., Pike, A.C.W., Savitsky, P., Keates, T., Pilka, E.S., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Knapp, S.
登録日2007-11-30
公開日2007-12-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase.
J.Biol.Chem., 286, 2011
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
分子名称:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
著者Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-10-16
公開日2005-11-07
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Structure of Casein Kinase 1 Gamma 2
To be Published
2X57
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
分子名称:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
著者Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
登録日2010-02-05
公開日2010-03-09
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
分子名称:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
著者Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-04-30
公開日2010-06-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
1XWS
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN
分子名称:Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2004-11-02
公開日2004-11-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of human PIM1 kinase domain
To be Published
2BIK
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HUMAN PIM1 PHOSPHORYLATED ON SER261
分子名称:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2005-01-22
公開日2005-02-07
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Human Pim1 Phosphorylated on Ser261
To be Published
2BIL
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THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE
分子名称:CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
著者Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
登録日2005-01-22
公開日2005-02-07
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
2BUJ
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CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE
分子名称:SERINE/THREONINE-PROTEIN KINASE 16, CHLORIDE ION, STAUROSPORINE
著者Debreczeni, J.E., Eswaran, J., Bullock, A., Filippakopoulos, P., Kavanagh, K., Amos, A., Fedorov, O., Sobott, F., Ball, L.J., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Knapp, S.
登録日2005-06-13
公開日2005-07-05
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine
To be Published
2BZH
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
分子名称:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RUTHENIUM-PYRIDOCARBAZOLE-1, 1,2-ETHANEDIOL, ...
著者Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-08-18
公開日2005-12-08
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZI
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2
分子名称:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RU-PYRIDOCARBAZOLE-2
著者Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-08-18
公開日2005-12-08
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZJ
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU3
分子名称:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RUTHENIUM-PYRIDOCARBAZOLE-3
著者Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-08-18
公開日2005-10-12
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZK
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE
分子名称:PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
登録日2005-08-18
公開日2005-11-03
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal Structure of the Human Pim1 in Complex with Amppnp and Pimtide
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
分子名称:Dual specificity protein kinase CLK3
著者Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-11-08
公開日2005-11-15
最終更新日2012-05-02
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2IHC
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CRYSTAL STRUCTURE OF THE BRIC-A-BRAC (BTB) DOMAIN OF HUMAN BACH1
分子名称:Transcription regulator protein BACH1
著者Amos, A.L., Turnbull, A.P., Bunkoczi, G., Papagrigoriou, E., Gorrec, F., Umeano, C., Bullock, A., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
登録日2006-09-26
公開日2006-10-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Crystal structure of the bric-a-brac (BTB) domain of human BACH1
To be Published
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
分子名称:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
著者Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
登録日2006-11-29
公開日2007-03-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2PPI
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STRUCTURE OF THE BTB (TRAMTRACK AND BRIC A BRAC) DOMAIN OF HUMAN GIGAXONIN
分子名称:Gigaxonin
著者Amos, A., Turnbull, A.P., Tickle, J., Keates, T., Bullock, A., Savitsky, P., Burgess-Brown, N., Debreczeni, J.E., Ugochukwu, E., Umeano, C., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2007-04-30
公開日2007-05-08
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin.
To be Published
2V24
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STRUCTURE OF THE HUMAN SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN SSB-4
分子名称:SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 4, NICKEL (II) ION
著者Uppenberg, J., Bullock, A., Keates, T., Savitsky, P., Pike, A.C.W., Ugochukwu, E., Bunkoczi, G., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
登録日2007-05-31
公開日2007-07-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4.
J.Mol.Biol., 401, 2010
2VPK
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN MYONEURIN
分子名称:MYONEURIN
著者Cooper, C.D.O., Murray, J.W., Bullock, A., Pike, A.C.W., von Delft, F., Filippakopoulos, P., Salah, E., Edwards, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Knapp, S.
登録日2008-02-29
公開日2008-03-11
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Btb Domain of Human Myoneurin
To be Published
2W4O
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CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITH 4-AMINO(SULFAMOYL- PHENYLAMINO)-TRIAZOLE-CARBOTHIOIC ACID (2,6-DIFLUORO-PHENYL)-AMIDE)
分子名称:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
著者Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.
登録日2008-11-28
公開日2009-01-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Crystal Structure of Human Camk4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
To be Published
3I3N
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CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMAN KLHL11
分子名称:Kelch-like protein 11, THIOCYANATE ION, CHLORIDE ION
著者Murray, J.W., Cooper, C.D.O., Krojer, T., Mahajan, P., Salah, E., Keates, T., Savitsky, P., Pike, A.C.W., Roos, A., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
登録日2009-06-30
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the BTB-BACK domains of human KLHL11
To be Published
3MDY
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN COMPLEX WITH FKBP12 AND LDN-193189
分子名称:Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
著者Chaikuad, A., Sanvitale, C., Mahajan, P., Daga, N., Cooper, C., Krojer, T., Alfano, I., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-03-31
公開日2010-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
分子名称:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
著者Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-08-31
公開日2010-10-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
3OP0
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CRYSTAL STRUCTURE OF CBL-C (CBL-3) TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
分子名称:Signal transduction protein CBL-C, Epidermal growth factor receptor, SODIUM ION, ...
著者Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-08-31
公開日2010-10-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
3PFV
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CRYSTAL STRUCTURE OF CBL-B TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
分子名称:E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ...
著者Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Muniz, J.R.C., Vollmar, M., Canning, P., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-10-29
公開日2010-12-08
最終更新日2014-04-02
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
分子名称:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
著者Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
登録日2010-11-30
公開日2010-12-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published