3SOC
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
Summary for 3SOC
Entry DOI | 10.2210/pdb3soc/pdb |
Related | 3Q4T |
Descriptor | Activin receptor type-2A, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | structural genomics consortium, sgc, transferase, protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P27037 |
Total number of polymer chains | 2 |
Total formula weight | 74543.15 |
Authors | Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-30, release date: 2011-07-20, Last modification date: 2023-09-13) |
Primary citation | Chaikuad, A.,Williams, E.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Muniz, J.R.C.,Yue, W.W.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin To be Published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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