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4EEY
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BU of 4eey by Molmil
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ...
Authors:Ummat, A, Rechkoblit, O, Jain, R, Choudhury, J.R, Johnson, R.E, Silverstein, T.D, Buku, A, Lone, S, Prakash, L, Prakash, S, Aggarwal, A.K.
Deposit date:2012-03-28
Release date:2012-05-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy.
Nat.Struct.Mol.Biol., 19, 2012
3TQ1
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BU of 3tq1 by Molmil
Human DNA Polymerase eta in binary complex with DNA
Descriptor: DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta
Authors:Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
Deposit date:2011-09-08
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.556 Å)
Cite:Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis.
J.Mol.Biol., 415, 2012
4PTF
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BU of 4ptf by Molmil
Ternary crystal structure of yeast DNA polymerase epsilon with template G
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*(DOC))-3', ...
Authors:Jain, R, Rajashankar, K.R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
Deposit date:2014-03-10
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.809 Å)
Cite:Crystal Structure of Yeast DNA Polymerase epsilon Catalytic Domain.
Plos One, 9, 2014
2LWE
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BU of 2lwe by Molmil
Solution structure of mutant (T170E) second CARD of human RIG-I
Descriptor: Probable ATP-dependent RNA helicase DDX58
Authors:Dutta, K, Ferrage, F, Aggarwal, A.
Deposit date:2012-07-27
Release date:2012-10-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
Structure, 20, 2012
2LWD
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BU of 2lwd by Molmil
Solution structure of second CARD of human RIG-I
Descriptor: Probable ATP-dependent RNA helicase DDX58
Authors:Dutta, K, Ferrage, F, Aggarwal, A.
Deposit date:2012-07-27
Release date:2012-10-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation.
Structure, 20, 2012
1XY2
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BU of 1xy2 by Molmil
CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
Descriptor: OXYTOCIN
Authors:Cooper, S, Blundell, T.L, Pitts, J.E, Wood, S.P, Tickle, I.J.
Deposit date:1987-06-05
Release date:1988-04-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science, 232, 1986
1XY1
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BU of 1xy1 by Molmil
CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING
Descriptor: BETA-MERCAPTOPROPIONATE-OXYTOCIN
Authors:Husain, J, Blundell, T.L, Wood, S.P, Tickle, I.J, Cooper, S, Pitts, J.E.
Deposit date:1987-06-05
Release date:1988-04-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science, 232, 1986
6D0Z
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BU of 6d0z by Molmil
Polymerase Eta cytarabine (AraC) extension ternary complex
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2018-04-11
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
5ULX
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BU of 5ulx by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine crystallized in the presence of dCTP
Descriptor: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(P*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
Authors:Jain, R, Aggarwal, A.K.
Deposit date:2017-01-25
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
6D0M
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BU of 6d0m by Molmil
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
Descriptor: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2018-04-10
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.832 Å)
Cite:Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
5ULW
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BU of 5ulw by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine
Descriptor: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(*TP*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
Authors:Jain, R, Aggarwal, A.K.
Deposit date:2017-01-25
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.617 Å)
Cite:Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
6Q02
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BU of 6q02 by Molmil
Polymerase Eta-catalyzed insertion of the mismatched A opposite template cytarabine (AraC) residue
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primer Strand, DNA polymerase eta, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2019-08-01
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
6PZ3
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BU of 6pz3 by Molmil
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA Primer strand, DNA polymerase eta, ...
Authors:Rechkoblit, O, Aggarwal, A.K.
Deposit date:2019-07-31
Release date:2019-11-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.395 Å)
Cite:Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
8FMF
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BU of 8fmf by Molmil
Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (1 tetramer in the AU)
Descriptor: Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate, GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K.
Deposit date:2022-12-23
Release date:2024-02-07
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Nat.Struct.Mol.Biol., 31, 2024
8FM1
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BU of 8fm1 by Molmil
Structure of CBASS Cap5 from Pseudomonas syringae in the absence of a ligand (apo form dimer)
Descriptor: SAVED domain-containing protein, ZINC ION
Authors:Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K.
Deposit date:2022-12-22
Release date:2024-02-07
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Nat.Struct.Mol.Biol., 31, 2024
8FMG
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BU of 8fmg by Molmil
Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-diAMP ligand (3 tetramers in the AU)
Descriptor: Cyclic (adenosine-(2'-5')-monophosphate-adenosine-(3'-5')-monophosphate, MAGNESIUM ION, SAVED domain-containing protein, ...
Authors:Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K.
Deposit date:2022-12-23
Release date:2024-02-07
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Nat.Struct.Mol.Biol., 31, 2024
8FMH
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BU of 8fmh by Molmil
Structure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-dGAMP ligand (2 tetramers in the AU)
Descriptor: 3'2'-cGAMP, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Rechkoblit, O, Kreitler, D.F, Aggarwal, A.K.
Deposit date:2022-12-23
Release date:2024-02-07
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Nat.Struct.Mol.Biol., 31, 2024
4ZBN
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BU of 4zbn by Molmil
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-nerve growth factor, DNA (28-MER)
Authors:Davies, D.R, Edwards, T.E.
Deposit date:2015-04-15
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.
Structure, 23, 2015

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