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1KFD
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BU of 1kfd by Molmil
CRYSTAL STRUCTURES OF THE KLENOW FRAGMENT OF DNA POLYMERASE I COMPLEXED WITH DEOXYNUCLEOSIDE TRIPHOSPHATE AND PYROPHOSPHATE
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA POLYMERASE I KLENOW FRAGMENT
Authors:Beese, L.S, Friedman, J.M, Steitz, T.A.
Deposit date:1993-09-23
Release date:1994-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate.
Biochemistry, 32, 1993
1KLN
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BU of 1kln by Molmil
DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor: DNA (5'-D(*GP*CP*CP*GP*CP*GP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*CP*GP*CP*GP*GP*CP*GP*GP*C)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), ...
Authors:Beese, L.S, Derbyshire, V, Steitz, T.A.
Deposit date:1994-05-24
Release date:1994-11-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
Science, 260, 1993
1FT2
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BU of 1ft2 by Molmil
CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor: FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ZINC ION
Authors:Beese, L.S, Casey, P.J, Long, S.B.
Deposit date:1998-06-02
Release date:1998-11-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry, 37, 1998
1FT1
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BU of 1ft1 by Molmil
CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE AT 2.25 ANGSTROMS RESOLUTION
Descriptor: PROTEIN FARNESYLTRANSFERASE, ZINC ION
Authors:Beese, L.S, Park, H.-W.
Deposit date:1997-03-17
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science, 275, 1997
8T70
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BU of 8t70 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, MET-ILE-ILE-MET, ...
Authors:Wang, Y, Beese, L.S.
Deposit date:2023-06-19
Release date:2023-08-09
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
To Be Published
1D8D
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BU of 1d8d by Molmil
CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION
Descriptor: ACETATE ION, K-RAS4B PEPTIDE SUBSTRATE, ZINC ION, ...
Authors:Long, S.B, Casey, P.J, Beese, L.S.
Deposit date:1999-10-22
Release date:2000-02-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1D8E
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BU of 1d8e by Molmil
Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog.
Descriptor: ACETATE ION, FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), ...
Authors:Long, S.B, Casey, P.J, Beese, L.S.
Deposit date:1999-10-22
Release date:2000-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
3TI0
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BU of 3ti0 by Molmil
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddGTP-dC in Closed Conformation
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*C*AP*TP*CP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3', ...
Authors:Wang, W, Beese, L.S.
Deposit date:2011-08-19
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
3BDP
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BU of 3bdp by Molmil
DNA POLYMERASE I/DNA COMPLEX
Descriptor: DNA (5'-D(*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*CP*2DT)-3'), PROTEIN (DNA POLYMERASE I), ...
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1997-11-17
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature, 391, 1998
8E9E
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BU of 8e9e by Molmil
Rat protein farnesyltransferase in complex with FPP and inhibitor 2f
Descriptor: (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2022-08-26
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
1XC9
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BU of 1xc9 by Molmil
Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication
Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Huang, X, Luneva, N.P, Geacintov, N.E, Beese, L.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication
J.Biol.Chem., 280, 2005
6UEU
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BU of 6ueu by Molmil
Crystal structure of BF DNA polymerase F710Y mutant bound to tetrahydrofuran and dATP
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*(3DR)P*AP*CP*GP*TP*GP*AP*TP*CP*G)-3'), ...
Authors:Wu, E.Y, Beese, L.S.
Deposit date:2019-09-23
Release date:2020-09-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for blockage of DNA synthesis by a thymine dimer lesion in a high-fidelity DNA polymerase
To Be Published
4L9P
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BU of 4l9p by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-06-18
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
2O8D
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BU of 2o8d by Molmil
human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*(DU)P*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
1XWL
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BU of 1xwl by Molmil
BACILLUS STEAROTHERMOPHILUS (NEWLY IDENTIFIED STRAIN AS YET UNNAMED) DNA POLYMERASE FRAGMENT
Descriptor: DNA POLYMERASE I, SULFATE ION
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1998-07-22
Release date:1999-01-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
Structure, 5, 1997
4LNG
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BU of 4lng by Molmil
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Descriptor: 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
4LNB
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BU of 4lnb by Molmil
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
4MBG
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BU of 4mbg by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-08-19
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
8FXU
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BU of 8fxu by Molmil
Thermoanaerobacter thermosaccharolyticum periplasmic Glucose-Binding Protein glucose complex: Badan conjugate attached at F17C
Descriptor: 2-bromo-1-[6-(dimethylamino)naphthalen-2-yl]ethan-1-one, CALCIUM ION, CHLORIDE ION, ...
Authors:Allert, M.J, Kumar, S, Beese, L.S, Hellinga, H.W.
Deposit date:2023-01-25
Release date:2023-08-30
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching.
Commun Chem, 6, 2023
8FXT
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BU of 8fxt by Molmil
Escherichia coli periplasmic Glucose-Binding Protein glucose complex: Acrylodan conjugate attached at W183C
Descriptor: 1-[6-(dimethylamino)naphthalen-2-yl]propan-1-one, CALCIUM ION, D-galactose/methyl-galactoside binding periplasmic protein MglB, ...
Authors:Allert, M.J, Kumar, S, Wang, Y, Beese, L.S, Hellinga, H.W.
Deposit date:2023-01-25
Release date:2023-08-30
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching.
Commun Chem, 6, 2023
7T0B
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BU of 7t0b by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0E
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BU of 7t0e by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T09
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BU of 7t09 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0C
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BU of 7t0c by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
7T0D
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BU of 7t0d by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.906 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022

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