Author results

1WRD
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CRYSTAL STRUCTURE OF TOM1 GAT DOMAIN IN COMPLEX WITH UBIQUITIN
Descriptor:Target of Myb protein 1, Ubiquitin
Authors:Akutsu, M., Kawasaki, M., Katoh, Y., Shiba, T., Yamaguchi, Y., Kato, R., Kato, K., Nakayama, K., Wakatsuki, S.
Deposit date:2004-10-14
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
Febs Lett., 579, 2005
3PHU
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS
Descriptor:RNA-directed RNA polymerase L, GLYCEROL
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHW
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN COMPLEX WITH UBIQUITIN
Descriptor:RNA-directed RNA polymerase L, Ubiquitin-40S ribosomal protein S27a, ETHANAMINE
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHX
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN COMPLEX WITH ISG15
Descriptor:RNA-directed RNA polymerase L, Ubiquitin-like protein ISG15, ZINC ION, ...
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
4P09
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CRYSTAL STRUCTURE OF HOIP PUB DOMAIN
Descriptor:E3 ubiquitin-protein ligase RNF31
Authors:Akutsu, M., Schaeffer, V., Olma, M.H., Gomes, L.C., Kawasaki, M., Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0A
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CRYSTAL STRUCTURE OF HOIP PUB DOMAIN IN COMPLEX WITH P97 PIM
Descriptor:E3 ubiquitin-protein ligase RNF31, Transitional endoplasmic reticulum ATPase
Authors:Akutsu, M., Schaeffer, V., Olma, M.H., Gomes, L.C., Kawasaki, M., Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3001 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0B
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CRYSTAL STRUCTURE OF HOIP PUB DOMAIN IN COMPLEX WITH OTULIN PIM
Descriptor:E3 ubiquitin-protein ligase RNF31, Ubiquitin thioesterase otulin
Authors:Akutsu, M., Schaeffer, V., Olma, M.H., Gomes, L.C., Kawasaki, M., Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7005 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
2ZFY
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CRYSTAL STRUCTURE OF HUMAN OTUBAIN 1
Descriptor:Ubiquitin thioesterase OTUB1
Authors:Akutsu, M., Walker, J.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-01-16
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural basis and specificity of human otubain 1-mediated deubiquitination.
Biochem.J., 418, 2009
3VVV
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SKICH DOMAIN OF NDP52
Descriptor:Calcium-binding and coiled-coil domain-containing protein 2
Authors:Akutsu, M., Muhlinen, N.V., Randow, F., Komander, D.
Deposit date:2012-07-28
Release date:2013-02-27
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
3VVW
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NDP52 IN COMPLEX WITH LC3C
Descriptor:Calcium-binding and coiled-coil domain-containing protein 2, Microtubule-associated proteins 1A/1B light chain 3C
Authors:Akutsu, M., Muhlinen, N.V., Randow, F., Komander, D.
Deposit date:2012-07-28
Release date:2013-02-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
6EIH
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THE CRYSTAL STRUCTURE OF 14-3-3 EPSILON IN COMPLEX WITH THE PHOSPHORYLATED NELFE PEPTIDE
Descriptor:14-3-3 protein epsilon, SER-ILE-SEP-ARG
Authors:Akutsu, M., Wagner, S.A., Beli, P.
Deposit date:2017-09-19
Release date:2018-02-14
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Nat Commun, 9, 2018
2ZVN
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NEMO COZI DOMAIN INCOMPLEX WITH DIUBIQUITIN IN P212121 SPACE GROUP
Descriptor:UBC protein, NF-kappa-B essential modulator
Authors:Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., Dikic, I.
Deposit date:2008-11-12
Release date:2009-03-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
2ZVO
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NEMO COZI DOMAIN IN COMPLEX WITH DIUBIQUITIN IN C2 SPACE GROUP
Descriptor:UBC protein, NF-kappa-B essential modulator
Authors:Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., Dikic, I.
Deposit date:2008-11-12
Release date:2009-03-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
3F89
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NEMO COZI DOMAIN
Descriptor:NF-kappa-B essential modulator
Authors:Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., Dikic, I.
Deposit date:2008-11-11
Release date:2009-03-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
4EU2
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CRYSTAL STRUCTURE OF 20S PROTEASOME WITH NOVEL INHIBITOR K-7174
Descriptor:Proteasome component C7-alpha, Proteasome component Y7, Proteasome component Y13, ...
Authors:Kikuchi, J., Shibayama, N., Yamada, S., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y., Ohki, M., Sugiyama, K., Park, S.-Y., Furukawa, Y.
Deposit date:2012-04-25
Release date:2013-05-01
Method:X-RAY DIFFRACTION (2.509 Å)
Cite:Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
Plos One, 8, 2013
4ZDV
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CRYSTAL STRUCTURE OF LC3 IN COMPLEX WITH FAM134B LIR
Descriptor:Microtubule-associated proteins 1A/1B light chain 3A
Authors:Khaminets, A., Grumati, P., Dikic, I., Akutsu, M.
Deposit date:2015-04-19
Release date:2015-06-03
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature, 522, 2015
5LRU
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN
Descriptor:OTU domain-containing protein 7B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRV
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO LYS11-LINKED DIUBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, GLYCEROL
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
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STRUCTURE OF A20 OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:Tumor necrosis factor alpha-induced protein 3, Polyubiquitin-B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
2WWZ
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED DI-UBIQUITIN, P212121
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX0
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED DI-UBIQUITIN, P21
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX1
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TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED TRI-UBIQUITIN, P212121
Descriptor:UBIQUITIN, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, ZINC ION
Authors:Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D.
Deposit date:2009-10-30
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2Y5B
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STRUCTURE OF USP21 IN COMPLEX WITH LINEAR DIUBIQUITIN-ALDEHYDE
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, UBIQUITIN, ZINC ION, ...
Authors:Ye, Y., Akutsu, M., Reyes-Turcu, F., Enchev, R.I., Wilkinson, K.D., Komander, D.
Deposit date:2011-01-12
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21.
Embo Rep., 12, 2011
3BFO
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CRYSTAL STRUCTURE OF IG-LIKE C2-TYPE 2 DOMAIN OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2)
Authors:Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-22
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
To be Published
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