Crystal structure of 20s proteasome with novel inhibitor K-7174

Summary for 4EU2

DescriptorProteasome component C7-alpha, Proteasome component Y7, Proteasome component Y13, ... (16 entities in total)
Functional Keywordsproteasome inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P21243 P23639 P23638 P40303 P32379 P40302 P21242 P38624 P25043 P25451 P22141 P30656 P23724 P30657
Total number of polymer chains28
Total molecular weight707188.29
Primary citation
Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Sugiyama, K.,Ohki, M.,Park, S.Y.,Furukawa, Y.
Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
Plos One, 8:e60649-e60649, 2013
PubMed: 23593271 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0060649
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2499 0.4% 9.3% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-28