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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4EU2

Crystal structure of 20s proteasome with novel inhibitor K-7174

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, OProteasome component C7-alphapolymer24127072.82UniProt (P21243)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, Proteasome component Y8, Proteinase YSCE subunit 7, SCL1 suppressor protein
2B, PProteasome component Y7polymer25027191.82UniProt (P23639)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit Y7, Multicatalytic endopeptidase complex subunit Y7, Proteinase YSCE subunit 7
3C, QProteasome component Y13polymer24427050.42UniProt (P23638)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteinase YSCE subunit 13
4D, RProteasome component PRE6polymer24126903.32UniProt (P40303)
Pfam (PF00227)
Pfam (PF10584)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteinase YSCE subunit PRE6
5E, SProteasome component PUP2polymer24226544.82UniProt (P32379)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteinase YSCE subunit PUP2
6F, TProteasome component PRE5polymer23325502.82UniProt (P40302)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5, Proteinase YSCE subunit PRE5
7G, UProteasome component C1polymer24426892.52UniProt (P21242)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, Proteinase YSCE subunit 1
8H, VProteasome component PRE3polymer19621517.22UniProt (P38624)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3, Proteinase YSCE subunit PRE3
9I, WProteasome component PUP1polymer22223987.32UniProt (P25043)
Pfam (PF00227)
Pfam (PF12465)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1, Proteinase YSCE subunit PUP1
10J, XProteasome component PUP3polymer20422496.62UniProt (P25451)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3
11K, YProteasome component C11polymer19822545.72UniProt (P22141)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteinase YSCE subunit 11
12L, ZProteasome component PRE2polymer21223353.32UniProt (P30656)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2, Proteinase YSCE subunit PRE2
13M, 1Proteasome component C5polymer22224883.92UniProt (P23724)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Multicatalytic endopeptidase complex subunit C5
14N, 2Proteasome component PRE4polymer23325945.52UniProt (P30657)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Macropain subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4, Proteinase YSCE subunit PRE4
15H, I, L, V, W...1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl]-1,4-diazepanenon-polymer568.76Chemie (WPI)
16waterwater18.01009Chemie (HOH)
Sequence modifications
L, Z: 1 - 212 (UniProt: P30656)
PDBExternal DatabaseDetails
Arg 33Lys 108conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains28
Total formula weight703775.8
Non-Polymers*Number of molecules6
Total formula weight3412.5
All*Total formula weight707188.3
*Water molecules are not included.

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PDB entries from 2024-09-25

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