4GGV | | CRYSTAL STRUCTURE OF HMTT INVOLVED IN HIMASTATIN BIOSYNTHESIS | | Descriptor: | Cytochrome P450 superfamily protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Zhang, H., Chen, J., Wang, H., Zhang, H. | | Deposit date: | 2012-08-07 | | Release date: | 2013-07-17 | | Method: | X-RAY DIFFRACTION (2.331 Å) | | Cite: | Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis
Febs Lett., 587, 2013
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5XEZ | | STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ... | | Authors: | Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. | | Deposit date: | 2017-04-06 | | Release date: | 2017-05-24 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
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5XF1 | | STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ... | | Authors: | Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. | | Deposit date: | 2017-04-06 | | Release date: | 2017-05-24 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
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5YQZ | | STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B. | | Deposit date: | 2017-11-08 | | Release date: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
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5GRM | | CRYSTAL STRUCTURE OF RAT STING IN COMPLEX WITH CYCLIC GMP-AMP WITH 2'5'AND 3'5'PHOSPHODIESTER LINKAGE(2'3'-CGAMP) | | Descriptor: | Stimulator of interferon genes protein, cGAMP | | Authors: | Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D. | | Deposit date: | 2016-08-11 | | Release date: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
To Be Published
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5GS5 | | CRYSTAL STRUCTURE OF APO RAT STING | | Descriptor: | Stimulator of interferon genes protein, SULFATE ION | | Authors: | Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D. | | Deposit date: | 2016-08-13 | | Release date: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of apo ratSTING
To Be Published
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4MM0 | | CRYSTAL STRUCTURE ANALYSIS OF THE PUTATIVE THIOETHER SYNTHASE SGVP INVOLVED IN THE TAILORING STEP OF GRISEOVIRIDIN | | Descriptor: | P450-like monooxygenase, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Zhang, H., Huang, L., Yi, M., Cai, T., Zhang, H. | | Deposit date: | 2013-09-07 | | Release date: | 2014-09-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin
To be Published
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4PV5 | | CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I IN COMPLEXED WITH 18-BETA-GLYCYRRHETINIC ACID | | Descriptor: | Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID | | Authors: | Zhang, H., Zhai, J., Zhang, L.P., Zhao, Y.N., Li, C., Hu, X.P. | | Deposit date: | 2014-03-15 | | Release date: | 2015-03-18 | | Last modified: | 2015-09-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor
Acta Pharmacol.Sin., 36, 2015
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3OFS | | DYNAMIC CONFORMATIONS OF THE CD38-MEDIATED NAD CYCLIZATION CAPTURED USING MULTI-COPY CRYSTALLOGRAPHY | | Descriptor: | ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | | Authors: | Zhang, H., Lee, H.C., Hao, Q. | | Deposit date: | 2010-08-16 | | Release date: | 2010-12-15 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
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4HFF | |
4HFK | |
4HFL | |
4X2A | | CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH BAICALEIN | | Descriptor: | Lactoylglutathione lyase, ZINC ION, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one | | Authors: | Zhang, H., Zhai, J., Zhang, L., Li, C., Zhao, Y., Hu, X. | | Deposit date: | 2014-11-26 | | Release date: | 2015-09-16 | | Last modified: | 2015-10-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | In Vitro Inhibition of Glyoxalase by Flavonoids: New Insights from Crystallographic Analysis
Curr Top Med Chem, 16, 2016
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1VQF | | GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY VAL 47 (V35I, I47V) | | Descriptor: | GENE V PROTEIN | | Authors: | Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C. | | Deposit date: | 1996-08-14 | | Release date: | 1997-02-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
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1VQI | | GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY VAL 47 (I47V) | | Descriptor: | GENE V PROTEIN | | Authors: | Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C. | | Deposit date: | 1996-08-14 | | Release date: | 1997-02-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
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1VQJ | | GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 (V35I) | | Descriptor: | GENE V PROTEIN | | Authors: | Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C. | | Deposit date: | 1996-08-14 | | Release date: | 1997-02-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
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5ZGE | | CRYSTAL STRUCTURE OF NDM-1 AT PH5.5 (BIS-TRIS) IN COMPLEX WITH HYDROLYZED AMPICILLIN | | Descriptor: | Metallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... | | Authors: | Zhang, H., Hao, Q. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2018-12-12 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
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1GP7 | |
1HS1 | |
1HS3 | |
1HS4 | |
3NSP | | CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD | | Descriptor: | Retinoid X receptor, alpha | | Authors: | Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-07-02 | | Release date: | 2010-11-17 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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3NSQ | | CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON | | Descriptor: | Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione | | Authors: | Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-07-02 | | Release date: | 2010-11-17 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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3R29 | | CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2 | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2 | | Authors: | Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2011-07-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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3R2A | | CRYSTAL STRUCTURE OF RXRALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH COREPRESSOR SMRT2 AND ANTAGONIST RHEIN | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor corepressor 2, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | | Authors: | Zhang, H., Chen, L., Chen, J., Jiang, H., Shen, X. | | Deposit date: | 2011-03-14 | | Release date: | 2011-05-25 | | Last modified: | 2011-07-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for retinoic x receptor repression on the tetramer.
J.Biol.Chem., 286, 2011
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