4PV5

Crystal structure of mouse glyoxalase I in complexed with 18-beta-glycyrrhetinic acid

Summary for 4PV5

Entry DOI	10.2210/pdb4pv5/pdb
Descriptor	Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID, ... (4 entities in total)
Functional Keywords	lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	42010.28
Authors	Zhang, H.,Zhai, J.,Zhang, L.P.,Zhao, Y.N.,Li, C.,Hu, X.P. (deposition date: 2014-03-15, release date: 2015-03-18, Last modification date: 2023-11-08)
Primary citation	Zhang, H.,Huang, Q.,Zhai, J.,Zhao, Y.N.,Zhang, L.P.,Chen, Y.Y.,Zhang, R.W.,Li, Q.,Hu, X.P. Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor Acta Pharmacol.Sin., 36:1145-1150, 2015 Cited by PubMed: 26279158 DOI: 10.1038/aps.2015.59 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation