3MK8
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4U6G
| Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide | Descriptor: | 10E8 Fab Heavy Chain, 10E8 Fab Light Chain, SAH-MPER(662-683KKK)(B,q) | Authors: | Ofek, G, Bird, G.H, Walensky, L.D, Kwong, P.D. | Deposit date: | 2014-07-28 | Release date: | 2014-12-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (4.2012 Å) | Cite: | Structural Fidelity and Neutralizing Antibody Binding Capacity of
Hydrocarbon-Stapled HIV-1 Antigens To be published
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2K7W
| BAX Activation is Initiated at a Novel Interaction Site | Descriptor: | Apoptosis regulator BAX, Bcl-2-like protein 11 | Authors: | Gavathiotis, E, Suzuki, M, Davis, M.L, Pitter, K, Bird, G.H, Katz, S.G, Tu, H.C, Kim, H, Cheng, E.H, Tjandra, N, Walensky, L.D. | Deposit date: | 2008-08-27 | Release date: | 2008-10-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | BAX activation is initiated at a novel interaction site. Nature, 455, 2008
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5WHI
| Crystal Structure of Bcl-2-related protein A1 | Descriptor: | Bcl-2-related protein A1, CACODYLIC ACID | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2017-07-17 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure, 26, 2018
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6VO4
| Crystal Structure Analysis of BFL1 | Descriptor: | Bcl-2-related protein A1 | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2020-01-29 | Release date: | 2020-06-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol, 27, 2020
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7S7G
| Crystal Structure Analysis of Human VLCAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2021-09-15 | Release date: | 2022-09-28 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun, 13, 2022
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5W89
| Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18 | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18 | Authors: | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-06-21 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5W8F
| Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14 | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14 | Authors: | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-06-21 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WHH
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4NGH
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4NHC
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6V4E
| Crystal Structure Analysis of Zebra Fish MDM | Descriptor: | Protein Mdm4, Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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6V4G
| Crystal Structure Analysis of Zebra fish MDMX | Descriptor: | Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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6V4H
| Crystal Structure Analysis of Zebra Fish MDMX | Descriptor: | Protein Mdm4, Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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6V4F
| Crystal Structure Analysis of Zebra Fish MDMX | Descriptor: | Protein Mdm4, SULFATE ION, Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2) | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2019-11-27 | Release date: | 2020-04-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
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