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1ZRO
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BU of 1zro by Molmil
Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose
Descriptor: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
Authors:Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
Deposit date:2005-05-19
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
1ZRL
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BU of 1zrl by Molmil
Crystal structure of EBA-175 Region II (RII)
Descriptor: CHLORIDE ION, SULFATE ION, erythrocyte binding antigen region II
Authors:Tolia, N.H, Enemark, E.J, Sim, B.K, Joshua-Tor, L.
Deposit date:2005-05-19
Release date:2005-08-09
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum.
Cell(Cambridge,Mass.), 122, 2005
4QJB
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BU of 4qjb by Molmil
Crystal structure of the sugar phosphatase PfHAD1 from Plasmodium falciparum
Descriptor: CHLORIDE ION, Haloacid dehalogenase-like hydrolase, MAGNESIUM ION
Authors:Tolia, N.H, Park, J.
Deposit date:2014-06-03
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.
Nat Commun, 5, 2014
3RRC
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BU of 3rrc by Molmil
Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein
Descriptor: 1,2-ETHANEDIOL, Duffy receptor, PHOSPHATE ION
Authors:Tolia, N.H.
Deposit date:2011-04-29
Release date:2011-07-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.
Nat.Struct.Mol.Biol., 18, 2011
4NUU
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BU of 4nuu by Molmil
Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
Descriptor: Duffy antigen/chemokine receptor, Duffy receptor
Authors:Tolia, N.H.
Deposit date:2013-12-04
Release date:2014-02-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
4NUV
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BU of 4nuv by Molmil
Heterotetramer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)
Descriptor: Duffy antigen/chemokine receptor, Duffy receptor, GLYCEROL
Authors:Tolia, N.H.
Deposit date:2013-12-04
Release date:2014-02-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.
Plos Pathog., 10, 2014
4K2U
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BU of 4k2u by Molmil
Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte binding antigen 175, ...
Authors:Tolia, N.H.
Deposit date:2013-04-09
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
4JNO
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BU of 4jno by Molmil
Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL) Region II in complex with sialyllactose
Descriptor: BAEBL protein, N-acetyl-alpha-neuraminic acid
Authors:Tolia, N.H.
Deposit date:2013-03-15
Release date:2013-03-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular Basis for Sialic Acid-dependent Receptor Recognition by the Plasmodium falciparum Invasion Protein Erythrocyte-binding Antigen-140/BAEBL.
J.Biol.Chem., 288, 2013
7K3Z
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BU of 7k3z by Molmil
P. falciparum Cpn60 D474A mutant bound to ATP
Descriptor: 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Tolia, N.H, Shi, D, Nguyen, B.
Deposit date:2020-09-14
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
Sci Rep, 11, 2021
5TSZ
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BU of 5tsz by Molmil
Crystal structure of Plasmodium vivax CelTOS
Descriptor: Pv cell-traversal protein, SODIUM ION
Authors:Tolia, N.H, Jimah, J.R.
Deposit date:2016-10-31
Release date:2016-12-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.002 Å)
Cite:Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.
Elife, 5, 2016
8DCC
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BU of 8dcc by Molmil
SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 3 Bound to P2B-2F6 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, P2B-2F6 Fab heavy chain, P2B-2F6 Fab light chain, ...
Authors:Dickey, T.D, Tolia, N.H.
Deposit date:2022-06-16
Release date:2022-07-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
Sci Adv, 8, 2022
6B2N
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BU of 6b2n by Molmil
Crystal structure of TEM-1 beta-lactamase mutant M182N
Descriptor: Beta-lactamase TEM, SULFATE ION
Authors:Jimah, J.R, Tolia, N.H.
Deposit date:2017-09-20
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
ACS Cent Sci, 3, 2017
6WG9
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BU of 6wg9 by Molmil
Crystal structure of tetracycline destructase Tet(X7)
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Tetracycline destructase Tet(X7)
Authors:Kumar, H, Tolia, N.H.
Deposit date:2020-04-05
Release date:2021-02-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance.
Commun Biol, 3, 2020
8GIF
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BU of 8gif by Molmil
Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 3
Descriptor: Apical membrane antigen 1, rhoptry neck protein 2 chimera
Authors:Patel, P.N, Tolia, N.H.
Deposit date:2023-03-14
Release date:2023-08-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
8GID
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BU of 8gid by Molmil
Crystal structure of a strain-transcending single-component Plasmodium falciparum AMA1-RON2L structure-based design immunogen 1 (SBD1)
Descriptor: Apical membrane antigen 1, rhoptry neck protein 2 chimera
Authors:Patel, P.N, Tolia, N.H.
Deposit date:2023-03-14
Release date:2023-08-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
8GIE
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BU of 8gie by Molmil
Crystal structure of a designed single-component Plasmodium falciparum AMA1-RON2L insertion fusion immunogen 2
Descriptor: Apical membrane antigen 1, rhoptry neck protein 2 chimera
Authors:Patel, P.N, Tolia, N.H.
Deposit date:2023-03-14
Release date:2023-08-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-based design of a strain transcending AMA1-RON2L malaria vaccine.
Nat Commun, 14, 2023
8ULF
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BU of 8ulf by Molmil
Crystal structure of Plasmodium vivax CelTOS in complex with antibody 7g7
Descriptor: 7g7 heavy chain, 7g7 light chain, Pv cell-traversal protein, ...
Authors:Tang, W.K, Tolia, N.H.
Deposit date:2023-10-16
Release date:2024-09-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria.
Nat Commun, 15, 2024
8UKH
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BU of 8ukh by Molmil
Crystal structure of Plasmodium falciparum CelTOS in complex with antibody 4h12
Descriptor: 4h12 heavy chain, 4h12 light chain, Cell traversal protein for ookinetes and sporozoites
Authors:Tang, W.K, Tolia, N.H, Urusova, D.
Deposit date:2023-10-13
Release date:2024-09-11
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria.
Nat Commun, 15, 2024
4QEX
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BU of 4qex by Molmil
Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte-binding antigen-175
Authors:Chen, E, Paing, M.M, Salinas, N, Sim, B.K, Tolia, N.H.
Deposit date:2014-05-19
Release date:2014-06-04
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
8DCE
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BU of 8dce by Molmil
SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 1 Bound to C144 scFv
Descriptor: C144 scFv, Spike protein S1
Authors:Tang, W.K, Tolia, N.H.
Deposit date:2022-06-16
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
Sci Adv, 8, 2022
8DFG
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BU of 8dfg by Molmil
Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19
Descriptor: 42D6 Fab Heavy Chain, 42D6 Fab Light Chain, Merozoite surface protein 1
Authors:Patel, P.N, Tang, W.K, Tolia, N.H.
Deposit date:2022-06-22
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.
Nat Commun, 13, 2022
8DFH
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BU of 8dfh by Molmil
Crystal structure of non-neutralizing / interfering human monoclonal antibody 42C3 Fab in complex with MSP1-19
Descriptor: 42C3 Fab Heavy Chain, 42C3 Fab Light Chain, Merozoite surface protein 1
Authors:Patel, P.N, Tang, W.K, Tolia, N.H.
Deposit date:2022-06-22
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.
Nat Commun, 13, 2022
8DFI
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BU of 8dfi by Molmil
Crystal structure of moderately neutralizing / interfering human monoclonal antibody 42C11 Fab in complex with MSP1-19
Descriptor: 42C11 Fab Heavy Chain, 42C11 Fab Light Chain, Merozoite surface protein 1
Authors:Patel, P.N, Tang, W.K, Tolia, N.H.
Deposit date:2022-06-22
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.
Nat Commun, 13, 2022
8E1Z
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BU of 8e1z by Molmil
Crystal structure of Plasmodium falciparum ookinete surface antigen Pfs28
Descriptor: CHLORIDE ION, Ookinete surface protein Pfs28, SULFATE ION
Authors:Shukla, N, Tang, W.K, Tolia, N.H.
Deposit date:2022-08-12
Release date:2022-11-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of Plasmodium falciparum ookinete surface antigen Pfs28 relevant for malaria vaccine design.
Sci Rep, 12, 2022
7U9E
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BU of 7u9e by Molmil
Pfs230 D1 domain in complex with 230AL-26
Descriptor: 230AL-26, Gametocyte surface protein P230, LMIV230-01
Authors:Tang, W.K, Tolia, N.H.
Deposit date:2022-03-10
Release date:2023-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine.
Immunity, 56, 2023

 

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