4QEX

Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217

Replaces:  4K4M

Summary for 4QEX

• Entry DOI: 10.2210/pdb4qex/pdb
• Related: 4K2U
• Descriptor: Erythrocyte-binding antigen-175, Antibody Light Chain, Antibody Heavy Chain (3 entities in total)
• Functional Keywords: duffy binding like (dbl) domain, immunoglobulin domain, invasion, adhesion, immunity, pfeba-175, antibody, cell surface, extrecellular, cell adhesion, receptor, ligand, immune system
• Biological source: Plasmodium falciparum; More
• Total number of polymer chains: 6
• Total formula weight: 237409.66

Authors

Chen, E.,Paing, M.M.,Salinas, N.,Sim, B.K.,Tolia, N.H. (deposition date: 2014-05-19, release date: 2014-06-04)

• Primary citation: Chen, E.,Paing, M.M.,Salinas, N.,Sim, B.K.,Tolia, N.H.; Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.; Plos Pathog., 9:e1003390-e1003390, 2013; PubMed: 23717209; DOI: 10.1371/journal.ppat.1003390

Experimental method

X-RAY DIFFRACTION (4.5 Å)