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6CES
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CRYO-EM STRUCTURE OF GATOR1-RAG
Descriptor:GATOR complex protein NPRL2, GATOR complex protein NPRL3, GATOR complex protein DEPDC5, ...
Authors:Shen, K., Huang, R.K., Brignole, E.J., Yu, Z., Sabatini, D.M.
Deposit date:2018-02-12
Release date:2018-03-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
6CET
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CRYO-EM STRUCTURE OF GATOR1
Descriptor:GATOR complex protein NPRL2, GATOR complex protein NPRL3, GATOR complex protein DEPDC5
Authors:Shen, K., Huang, R.K., Brignole, E.J., Yu, Z., Sabatini, D.M.
Deposit date:2018-02-12
Release date:2018-03-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Nature, 556, 2018
6ULG
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CRYO-EM STRUCTURE OF THE FLCN-FNIP2-RAG-RAGULATOR COMPLEX
Descriptor:Folliculin, Ragulator complex protein LAMTOR3, Ragulator complex protein LAMTOR2, ...
Authors:Shen, K., Rogala, K.B., Yu, Z.H., Sabatini, D.M.
Deposit date:2019-10-08
Release date:2019-11-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019
5VOK
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CRYSTAL STRUCTURE OF THE C7ORF59-HBXIP DIMER
Descriptor:Ragulator complex protein LAMTOR5, Ragulator complex protein LAMTOR4
Authors:Rasheed, N., Nascimento, A.F.Z., Bar-Peled, L., Shen, K., Sabatini, D.M., Aparicio, R., Smetana, J.H.C.
Deposit date:2017-05-03
Release date:2018-05-23
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.
Febs Open Bio, 2019
6XS6
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SARS-COV-2 SPIKE D614G VARIANT, MINUS RBD
Descriptor:Spike glycoprotein
Authors:Wang, X., Egri, S.B., Dudkina, N., Luban, J., Shen, K.
Deposit date:2020-07-15
Release date:2020-07-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Biorxiv, 2020
1PXH
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CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B WITH POTENT AND SELECTIVE BIDENTATE INHIBITOR COMPOUND 2
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, ...
Authors:Sun, J.P., Fedorov, A., Lee, S.Y., Guo, X.L., Shen, K., Lawrence, D.S., Almo, S.C., Zhang, Z.Y.
Deposit date:2003-07-04
Release date:2003-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
J.Biol.Chem., 278, 2003
2CCH
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THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
2CCI
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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6
Descriptor:Cyclin-dependent kinase 2, Cyclin-A2, Cell division control protein 6 homolog, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2GS2
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CRYSTAL STRUCTURE OF THE ACTIVE EGFR KINASE DOMAIN
Descriptor:Epidermal growth factor receptor
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
2GS6
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CRYSTAL STRUCTURE OF THE ACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AN ATP ANALOG-PEPTIDE CONJUGATE
Descriptor:Epidermal growth factor receptor, Peptide, CHLORIDE ION, ...
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
2GS7
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CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP
Descriptor:Epidermal growth factor receptor, MAGNESIUM ION, IODIDE ION, ...
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
2XXA
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THE CRYSTAL STRUCTURE OF THE SIGNAL RECOGNITION PARTICLE (SRP) IN COMPLEX WITH ITS RECEPTOR(SR)
Descriptor:SIGNAL RECOGNITION PARTICLE PROTEIN, SRP RECEPTOR FTSY, 4.5S RNA, ...
Authors:Ataide, S.F., Schmitz, N., Shen, K., Ke, A., Shan, S., Doudna, J.A., Ban, N.
Deposit date:2010-11-09
Release date:2011-03-02
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:The Crystal Structure of the Signal Recognition Particle in Complex with its Receptor.
Science, 331, 2011
4C7O
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THE STRUCTURAL BASIS OF FTSY RECRUITMENT AND GTPASE ACTIVATION BY SRP RNA
Descriptor:SIGNAL RECOGNITION PARTICLE PROTEIN, SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY, SRP RNA, ...
Authors:Voigts-Hoffmann, F., Schmitz, N., Shen, K., Shan, S.O., Ataide, S.F., Ban, N.
Deposit date:2013-09-23
Release date:2013-11-20
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis of Ftsy Recruitment and Gtpase Activation by Srp RNA
Mol.Cell, 52, 2013
6CSM
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CRYSTAL STRUCTURE OF THE NATURAL LIGHT-GATED ANION CHANNEL GTACR1
Descriptor:GtACR1, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSN
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH8.5
Descriptor:iC++, RETINAL, OLEIC ACID, ...
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSO
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH6.5
Descriptor:iC++, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
4FQ5
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO(C200A) FROM PSEUDOMONAS PUTIDA S16 WITH MALEATE
Descriptor:Maleate cis-trans isomerase, MALEIC ACID
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
4FQ7
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO FROM PSEUDOMONAS PUTIDA S16
Descriptor:Maleate cis-trans isomerase
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
2G1T
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A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN
Descriptor:Proto-oncogene tyrosine-protein kinase ABL1, ATP-Peptide Conjugate, MAGNESIUM ION, ...
Authors:Levinson, N.M., Kuchment, O.
Deposit date:2006-02-14
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G2F
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A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN
Descriptor:Abl Kinase, ATP-Peptide Conjugate, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Levinson, N.M., Kuchment, O.
Deposit date:2006-02-15
Release date:2006-05-23
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G2H
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A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN
Descriptor:Abl Tyrosine, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
Authors:Levinson, N.M., Kuchment, O.
Deposit date:2006-02-16
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
2G2I
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A SRC-LIKE INACTIVE CONFORMATION IN THE ABL TYROSINE KINASE DOMAIN
Descriptor:Abl Tyrosine Kinase, ATP-Peptide Conjugate, ADENOSINE-5'-DIPHOSPHATE
Authors:Levinson, N.M., Kuchment, O.
Deposit date:2006-02-16
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:A SRC-like inactive conformation in the abl tyrosine kinase domain.
Plos Biol., 4, 2006
3RZ2
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CRYSTAL OF PRL-1 COMPLEXED WITH PEPTIDE
Descriptor:Protein tyrosine phosphatase type IVA 1, Prl-1 (PTP4A1)
Authors:Zhang, Z.-Y., Liu, D., Bai, Y.
Deposit date:2011-05-11
Release date:2011-10-26
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
J.Biol.Chem., 286, 2011
3UWX
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CRYSTAL STRUCTURE OF UVRA-UVRB COMPLEX
Descriptor:Excinuclease ABC, A subunit, UvrABC system protein B, ...
Authors:Pakotiprapha, D., Jeruzalmi, D.
Deposit date:2011-12-03
Release date:2012-02-08
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (4.398 Å)
Cite:Structure and mechanism of the UvrA-UvrB DNA damage sensor.
Nat.Struct.Mol.Biol., 19, 2012
3UX8
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CRYSTAL STRUCTURE OF UVRA
Descriptor:Excinuclease ABC, A subunit, ZINC ION, ...
Authors:Samuels, M.A., Pakotiprapha, D., Jeruzalmi, D.
Deposit date:2011-12-04
Release date:2012-02-08
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of the UvrA-UvrB DNA damage sensor.
Nat.Struct.Mol.Biol., 19, 2012
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PDB entries from 2020-08-05