Author results

1N3L
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CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASE CYTOKINE
Descriptor:tyrosyl-tRNA synthetase, SULFATE ION, GLYCEROL
Authors:Yang, X.-L., Skene, R.J., McRee, D.E., Schimmel, P.
Deposit date:2002-10-28
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Proc.Natl.Acad.Sci.USA, 99, 2002
4EQE
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH LYS-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQG
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH ALA-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
1Q11
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CRYSTAL STRUCTURE OF AN ACTIVE FRAGMENT OF HUMAN TYROSYL-TRNA SYNTHETASE WITH TYROSINOL
Descriptor:Tyrosyl-tRNA synthetase, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Yang, X.-L., Schimmel, P., Ribas de Pouplana, L.
Deposit date:2003-07-18
Release date:2004-01-06
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc.Natl.Acad.Sci.USA, 100, 2003
2GVK
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CRYSTAL STRUCTURE OF A DYE-DECOLORIZING PEROXIDASE (DYP) FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 AT 1.6 A RESOLUTION
Descriptor:Heme peroxidase, CHLORIDE ION, SODIUM ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-05-02
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
Proteins, 69, 2007
5THL
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CRYSTAL STRUCTURE OF THE HUMAN TYROSYL-TRNA SYNTHETASE MUTANT G41R
Descriptor:Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D., Sajish, M., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
4EQH
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH TRP-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
3G98
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CRYSTAL STRUCTURE OF THE C-ALA DOMAIN FROM AQUIFEX AEOLICUS ALANYL-TRNA SYNTHETASE
Descriptor:Alanyl-tRNA synthetase
Authors:Guo, M., Yang, X.L., Schimmel, P.
Deposit date:2009-02-13
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science, 325, 2009
3ERS
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CRYSTAL STRUCTURE OF E. COLI TRBP111
Descriptor:tRNA-binding protein ygjH
Authors:Swairjo, M.A.
Deposit date:2008-10-03
Release date:2008-12-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of Trbp111: a tructure specific tRNA binding protein
Embo J., 19, 2000
3HY0
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS G237A IN COMPLEX WITH GLYSA
Descriptor:Alanyl-tRNA synthetase, 5'-O-(glycylsulfamoyl)adenosine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
5K9G
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CRYSTAL STRUCTURE OF GTP CYCLOHYDROLASE-IB WITH TRIS
Descriptor:GTP cyclohydrolase FolE2, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Alvarez, J., Stec, B., Swairjo, M.A.
Deposit date:2016-05-31
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB.
J.Bacteriol., 191, 2009
3HXV
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS IN COMPLEX WITH GLYSA
Descriptor:Alanyl-tRNA synthetase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 2-HYDROXYETHYL DISULFIDE, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
3HXW
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS IN COMPLEX WITH SERSA
Descriptor:Alanyl-tRNA synthetase, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
5THH
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-TRNA SYNTHETASE MUTANT
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, TYROSINE
Authors:Blocquel, D., Yang, X.L.
Deposit date:2016-09-29
Release date:2017-05-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
3HXZ
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS G237A IN COMPLEX WITH ALASA
Descriptor:Alanyl-tRNA synthetase, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
1Q7S
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CRYSTAL STRUCTURE OF BIT1
Descriptor:bit1
Authors:De Pereda, J.M., Waas, W.F., Jan, Y., Ruoslahti, E., Schimmel, P., Pascual, J.
Deposit date:2003-08-19
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity.
J.Biol.Chem., 279, 2004
1R6U
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CRYSTAL STRUCTURE OF AN ACTIVE FRAGMENT OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE WITH CYTOKINE ACTIVITY
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL
Authors:Yang, X.-L., Otero, F.J., Skene, R.J., McRee, D.E., Ribas de Pouplana, L., Schimmel, P.
Deposit date:2003-10-16
Release date:2004-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase
Structure, 15, 2007
4HVC
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH HALOFUGINONE AND ATP ANALOGUE
Descriptor:Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
Authors:Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
Deposit date:2012-11-06
Release date:2013-01-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
5T76
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5V59
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF HUMAN ALARS IN COMPLEX WITH AZE-SA
Descriptor:Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine
Authors:Zhou, H., Song, Y., Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
3D2O
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CRYSTAL STRUCTURE OF MANGANESE-METALLATED GTP CYCLOHYDROLASE TYPE IB
Descriptor:UPF0343 protein NGO0387, MANGANESE (II) ION, LITHIUM ION, ...
Authors:Swairjo, M.A.
Deposit date:2008-05-08
Release date:2009-05-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB
J.Bacteriol., 191, 2009
1YFS
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THE CRYSTAL STRUCTURE OF ALANYL-TRNA SYNTHETASE IN COMPLEX WITH L-ALANINE
Descriptor:Alanyl-tRNA synthetase, ALANINE
Authors:Swairjo, M.A., Schimmel, P.R.
Deposit date:2005-01-03
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 102, 2005
1R6T
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CRYSTAL STRUCTURE OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL
Authors:Yang, X.-L., Otero, F.J., Skene, R.J., McRee, D.E., Ribas de Pouplana, L., Schimmel, P.
Deposit date:2003-10-16
Release date:2004-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc.Natl.Acad.Sci.USA, 100, 2003
3HXU
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF E. COLI ALARS IN COMPLEX WITH ALASA
Descriptor:Alanyl-tRNA synthetase, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 2-HYDROXYETHYL DISULFIDE, ...
Authors:Guo, M., Yang, X.-L., Schimmel, P.
Deposit date:2009-06-22
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
Nature, 462, 2009
4Q93
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CRYSTAL STRUCTURE OF RESVERATROL BOUND HUMAN TYROSYL TRNA SYNTHETASE
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, RESVERATROL, ...
Authors:Mathew, S., Schimmel, P.
Deposit date:2014-04-28
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
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