Author results

1YII
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CRYSTAL STRUCTURES OF CHICKEN ANNEXIN V IN COMPLEX WITH CA2+
Descriptor:Annexin A5, SULFATE ION, CALCIUM ION
Authors:Ortlund, E.A., Chai, G., Genge, B., Wu, L.N.Y., Wuthier, R.E., Lebioda, L.
Deposit date:2005-01-11
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structures of Chicken Annexin A5 in Complex with Functional Modifiers Ca2+ and Zn2+ Reveal Zn2+ Induced Formation of Non-Planar Assemblies
Annexins, 1, 2005
1YJ0
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CRYSTAL STRUCTURES OF CHICKEN ANNEXIN V IN COMPLEX WITH ZN2+
Descriptor:Annexin A5, SULFATE ION, ZINC ION
Authors:Ortlund, E.A., Chai, G., Genge, B., Wu, L.N.Y., Wuthier, R.E., Lebioda, L.
Deposit date:2005-01-11
Release date:2005-03-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal Structures of Chicken Annexin A5 in Complex with Functional Modifiers Ca2+ and Zn2+ Reveal Zn2+ Induced Formation of Non-Planar Assemblies
Annexins, 1, 2005
1YUC
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO PHOSPHOLIPID AND A FRAGMENT OF HUMAN SHP
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor 0B2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Ortlund, E.A., Yoonkwang, L., Solomon, I.H., Hager, J.M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C.R.H., McDonnell, D.P., Moore, D.D., Redinbo, M.R.
Deposit date:2005-02-13
Release date:2005-03-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
Nat.Struct.Mol.Biol., 12, 2005
2Q1H
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ANCESTRAL CORTICOID RECEPTOR IN COMPLEX WITH ALDOSTERONE
Descriptor:AncCR, SODIUM ION, ALDOSTERONE, ...
Authors:Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., Thornton, J.W.
Deposit date:2007-05-24
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q1V
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ANCESTRAL CORTICOID RECEPTOR IN COMPLEX WITH CORTISOL
Descriptor:AncCR, 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, GLYCEROL
Authors:Ortlund, E.A., Redinbo, M.R.
Deposit date:2007-05-25
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q3Y
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ANCESTRAL CORTICIOD RECEPTOR IN COMPLEX WITH DOC
Descriptor:Ancestral Corticiod Receptor, Nuclear receptor 0B2, DESOXYCORTICOSTERONE, ...
Authors:Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., Thornton, J.W.
Deposit date:2007-05-30
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
5W75
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ortlund, E.A.
Deposit date:2017-06-19
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018
5W76
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Ancestral Elogation Factor N153, MAGNESIUM ION, SULFATE ION, ...
Authors:Ortlund, E.A.
Deposit date:2017-06-19
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018
5W7Q
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Consensus Elongation Factor, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ortlund, E.A.
Deposit date:2017-06-20
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018
3B74
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CRYSTAL STRUCTURE OF YEAST SEC14 HOMOLOG SFH1 IN COMPLEX WITH PHOSPHATIDYLETHANOLAMINE
Descriptor:Uncharacterized protein YKL091C, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Authors:Ortlund, E.A., Schaaf, G., Redinbo, M.R., Bankaitis, V.
Deposit date:2007-10-30
Release date:2008-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
Mol.Cell, 29, 2008
3B7N
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CRYSTAL STRUCTURE OF YEAST SEC14 HOMOLOG SFH1 IN COMPLEX WITH PHOSPHATIDYLINOSITOL
Descriptor:Uncharacterized protein YKL091C, PHOSPHATE ION, ACETATE ION, ...
Authors:Ortlund, E.A., Schaaf, G., Redinbo, M.R., Bankaitis, V.
Deposit date:2007-10-31
Release date:2008-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
Mol.Cell, 29, 2008
3B7Q
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CRYSTAL STRUCTURE OF YEAST SEC14 HOMOLOG SFH1 IN COMPLEX WITH PHOSPHATIDYLCHOLINE
Descriptor:Uncharacterized protein YKL091C, PHOSPHATE ION, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, ...
Authors:Ortlund, E.A., Schaaf, G., Redinbo, M.R., Bankaitis, V.
Deposit date:2007-10-31
Release date:2008-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
Mol.Cell, 29, 2008
3B7Z
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CRYSTAL STRUCTURE OF YEAST SEC14 HOMOLOG SFH1 IN COMPLEX WITH PHOSPHATIDYLCHOLINE OR PHOSPHATIDYLINOSITOL
Descriptor:Uncharacterized protein YKL091C, (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE
Authors:Ortlund, E.A., Schaaf, G., Redinbo, M.R., Bankaitis, V.
Deposit date:2007-10-31
Release date:2008-02-19
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
Mol.Cell, 29, 2008
3GN8
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X-RAY CRYSTAL STRUCTURE OF ANCGR2 IN COMPLEX WITH DEXAMETHASONE
Descriptor:Glucocorticoid receptor 2, Nuclear receptor coactivator 2, DEXAMETHASONE
Authors:Ortlund, E.A.
Deposit date:2009-03-16
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
Nature, 461, 2009
3Q8G
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RESURRECTION OF A FUNCTIONAL PHOSPHATIDYLINOSITOL TRANSFER PROTEIN FROM A PSEUDO-SEC14 SCAFFOLD BY DIRECTED EVOLUTION
Descriptor:CRAL-TRIO domain-containing protein YKL091C, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, GLYCEROL
Authors:Ortlund, E.A., Schaaf, G., Bankaitis, V.A.
Deposit date:2011-01-06
Release date:2011-02-23
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
Mol.Biol.Cell, 22, 2011
3RY9
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CRYSTAL STRUCTURE OF THE RESURRECTED ANCESTRAL GLUCOCORTICOID RECEPTOR 1 IN COMPLEX WITH DOC
Descriptor:Ancestral Glucocorticoid Receptor 1, GLYCEROL, DESOXYCORTICOSTERONE, ...
Authors:Ortlund, E.A.
Deposit date:2011-05-11
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
PLoS Genet, 7, 2011
4FNE
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X-RAY CRYSTAL STRUCTURE OF THE ANCESTRAL 3-KETO STEROID RECEPTOR - DOC COMPLEX
Descriptor:Steroid receptor 2, DESOXYCORTICOSTERONE, SULFATE ION, ...
Authors:Ortlund, E.A., Colucci, J.K., Thornton, J., Eick, G., Harms, M.
Deposit date:2012-06-19
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet, 8, 2012
4LTW
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ANCESTRAL KETOSTEROID RECEPTOR-PROGESTERONE-MIFEPRISTONE COMPLEX
Descriptor:Ancestral Steroid Receptor 2, PROGESTERONE, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Ortlund, E.A., Colucci, J.K.
Deposit date:2013-07-24
Release date:2013-12-25
Method:X-RAY DIFFRACTION (2.045 Å)
Cite:X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.
Plos One, 8, 2013
4OV7
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ANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - SRE DNA COMPLEX
Descriptor:Ancestral Steroid Receptor 2 DBD helix mutant, 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', ...
Authors:Ortlund, E.A.
Deposit date:2014-02-20
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4PLE
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO AN E. COLI PHOSPHOLIPID AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Ortlund, E.A., Musille, P.M.
Deposit date:2014-05-16
Release date:2015-12-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
J.Biol.Chem., 291, 2016
5SYZ
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HUMAN LIVER RECEPTOR HOMOLOGUE-1 (LRH-1) BOUND TO A RJW100 STEREOISOMER AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol
Authors:Ortlund, E.A., Mays, S.G.
Deposit date:2016-08-12
Release date:2016-10-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.9261 Å)
Cite:Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
J. Biol. Chem., 291, 2016
5CC1
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S425G GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Weikum, E.A., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5E69
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL8 NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*GP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*CP*GP*AP*T)-3'), DNA (5'-D(*AP*TP*CP*GP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*C)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6A
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - PLAU NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*GP*AP*T)-3'), DNA (5'-D(*AP*TP*CP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*G)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6B
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - RELB NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*GP*GP*CP*GP*GP*AP*AP*TP*TP*CP*CP*CP*CP*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*GP*GP*AP*AP*TP*TP*CP*CP*GP*CP*CP*G)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
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