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1ZX1
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HUMAN QUINONE OXIDOREDUCTASE 2 (NQO2) IN COMPLEX WITH THE CYTOSTATIC PRODRUG CB1954
分子名称:NRH dehydrogenase [quinone] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Jansson, A., Wu, X., Kavanagh, K., Kerr, D., Knox, R., Walton, R., Gunther, U., Ludwig, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-06-06
公開日2005-06-14
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
To be Published
4UF0
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CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY IN COMPLEX WITH EPITHERAPUETIC COMPOUND 2-(((2-((2-(DIMETHYLAMINO)ETHYL) (ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL)ISONICOTINIC ACID.
分子名称:HISTONE DEMETHYLASE UTY, FE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Tobias, K., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
登録日2014-12-22
公開日2015-01-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A1F
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PLU1 IN COMPLEX WITH N-OXALYLGLYCINE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, N-OXALYLGLYCINE, ...
著者Srikannathasan, V., Johansson, C., Strain-Damerell, C., Gileadi, C., Szykowska, A., Kupinska, K., Kopec, J., Krojer, T., Steuber, H., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-04-29
公開日2015-05-06
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3P
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLU1 (JARID1B).
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Tallant, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-02
公開日2015-06-10
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.008 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3T
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CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH KDM5-C49 (2-(((2-((2-(DIMETHYLAMINO)ETHYL)(ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL) ISONICOTINIC ACID).
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., BurgessBrown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-02
公開日2015-06-17
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3W
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CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH PYRIDINE-2, 6-DICARBOXYLIC ACID (PDCA)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, SODIUM ION, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-03
公開日2015-06-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FPU
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSKJ1
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ...
著者Srikannathasan, V., Nowak, R., Johansson, C., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
登録日2015-12-03
公開日2016-01-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FPV
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CRYSTAL STRUCTURE OF HUMAN JMJD2A IN COMPLEX WITH COMPOUND KDOAM20A
分子名称:LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ...
著者Srikannathasan, V., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
登録日2015-12-03
公開日2016-01-13
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FUN
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSK467
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4(3H)-one, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Brennan, P., Oppermann, U.
登録日2016-01-28
公開日2016-04-13
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FUP
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH 2-OXOGLUTARATE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2016-01-28
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FV3
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CRYSTAL STRUCTURE OF HUMAN JARID1B CONSTRUCT C2 IN COMPLEX WITH N- OXALYLGLYCINE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2016-02-02
公開日2016-02-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FWJ
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CRYSTAL STRUCTURE OF HUMAN JARID1C IN COMPLEX WITH KDM5-C49
分子名称:HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ...
著者Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U.
登録日2016-02-17
公開日2016-04-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
1T2A
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CRYSTAL STRUCTURE OF HUMAN GDP-D-MANNOSE 4,6-DEHYDRATASE
分子名称:GDP-mannose 4,6 dehydratase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE
著者Walker, J.R., Vedadi, M., Sharma, S., Houston, S., Wasney, G., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Oppermann, U.
登録日2004-04-20
公開日2004-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Crystal Structure and Biophysical Characterization of Human GDP-D-mannose 4,6-dehydratase
To be Published
1XG5
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STRUCTURE OF HUMAN PUTATIVE DEHYDROGENASE MGC4172 IN COMPLEX WITH NADP
分子名称:ARPG836, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETIC ACID
著者Kavanagh, K., Ng, S., Sharma, S., Vedadi, M., von Delft, F., Walker, J.R., dhe Paganon, S., Bray, J., Oppermann, U., Edwards, A., Arrowsmith, C., Sundstrom, M., Structural Genomics Consortium (SGC)
登録日2004-09-16
公開日2004-10-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Structural Genomics Consortium: Structure of the putative human dehydrogenase MGC4172
To be Published
1XSE
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CRYSTAL STRUCTURE OF GUINEA PIG 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
分子名称:11beta-hydroxysteroid dehydrogenase type 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Ogg, D., Elleby, B., Norstrom, C., Stefansson, K., Abrahmsen, L., Oppermann, U., Svensson, S.
登録日2004-10-19
公開日2004-11-16
最終更新日2018-08-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
J.Biol.Chem., 280, 2005
1YB1
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CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE XI
分子名称:17-beta-hydroxysteroid dehydrogenase type XI, CHLORIDE ION, SULFATE ION, ...
著者Lukacik, P., Bunkoczi, G., Kavanagh, K., Ng, S., von Delft, F., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2004-12-18
公開日2004-12-28
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.
To be Published
1YB5
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CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN WITH BOUND NADP
分子名称:Quinone oxidoreductase, ACETATE ION, CHLORIDE ION, ...
著者Debreczeni, J., Berridge, G., Kavanagh, K., Colbrook, S., Bray, J., Williams, L., Oppermann, U., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., von Delft, F., Structural Genomics Consortium (SGC)
登録日2004-12-20
公開日2004-12-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of human Zeta-Crystallin at 1.85A
To be Published
1YDE
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CRYSTAL STRUCTURE OF HUMAN RETINAL SHORT-CHAIN DEHYDROGENASE/REDUCTASE 3
分子名称:Retinal dehydrogenase/reductase 3
著者Lukacik, P., Bunkozci, G., Kavanagh, K., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2004-12-23
公開日2005-01-18
最終更新日2012-03-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Biochem.J., 402, 2007
1YQ7
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH RISEDRONATE
分子名称:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Kavanagh, K.L., Guo, K., Von delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-02-01
公開日2005-02-22
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Human farnesyl diphosphate complexed with clinical inhibitor risedronate
To be Published
1YV5
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HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND RISEDRONATE
分子名称:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Kavanagh, K.L., Guo, K., Von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-02-15
公開日2005-03-01
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1YXM
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CRYSTAL STRUCTURE OF PEROXISOMAL TRANS 2-ENOYL COA REDUCTASE
分子名称:peroxisomal trans 2-enoyl CoA reductase, SULFATE ION, PHOSPHATE ION, ...
著者Jansson, A., Ng, S., Arrowsmith, C., Sharma, S., Edwards, A.M., Von Delft, F., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-02-22
公開日2005-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of perixomal trans 2-enoyl CoA reductase (PECRA)
To be Published
1Z6Z
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CRYSTAL STRUCTURE OF HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH NADP+
分子名称:Sepiapterin reductase, SULFATE ION, CHLORIDE ION, ...
著者Ugochukwu, E., Kavanagh, K., Ng, S., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-04-05
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Human Sepiapterin Reductase
To be Published
1ZBQ
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CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 4 IN COMPLEX WITH NAD
分子名称:17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Lukacik, P., Shafqat, N., Kavanagh, K., Bray, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-04-08
公開日2005-04-26
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
To be Published
1ZSV
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CRYSTAL STRUCTURE OF HUMAN NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE
分子名称:NADP-dependent leukotriene B4 12-hydroxydehydrogenase, CHLORIDE ION
著者Turnbull, A.P., Johansson, C., Savitsky, P., Guo, K., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-05-25
公開日2005-06-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase
To be Published
1ZSX
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CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNIT (KCNAB2)
分子名称:Voltage-gated potassium channel beta-2 subunit, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wennerstrand, P., Johannsson, I., Ugochukwu, E., Kavanagh, K., Edwards, A., Arrowsmith, C., Williams, L., Sundstrom, M., Guo, K., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-05-25
公開日2005-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)
To be Published