Author results

6COY
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HUMAN CLC-1 CHLORIDE ION CHANNEL, TRANSMEMBRANE DOMAIN
Descriptor:Chloride channel protein 1, CHLORIDE ION
Authors:Park, E., MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6COZ
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HUMAN CLC-1 CHLORIDE ION CHANNEL, C-TERMINAL CYTOSOLIC DOMAIN
Descriptor:Chloride channel protein 1
Authors:Park, E., MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6CNM
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, POTASSIUM ION, ...
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNN
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX IN THE CA2+ BOUND STATE I
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, POTASSIUM ION, ...
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNO
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX IN THE CA2+ BOUND STATE II
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, CALCIUM ION
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6C3O
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CRYO-EM STRUCTURE OF HUMAN KATP BOUND TO ATP AND ADP IN QUATREFOIL FORM
Descriptor:ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lee, K.P.K., Chen, J., MacKinnon, R.
Deposit date:2018-01-10
Release date:2018-01-31
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of human KATP in complex with ATP and ADP
Elife, 6, 2017
6C3P
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CRYO-EM STRUCTURE OF HUMAN KATP BOUND TO ATP AND ADP IN PROPELLER FORM
Descriptor:ATP-sensitive inward rectifier potassium channel 11, ATP-binding cassette sub-family C member 8, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lee, K.P.K., Chen, J., MacKinnon, R.
Deposit date:2018-01-10
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Molecular structure of human KATP in complex with ATP and ADP.
Elife, 6, 2017
6B3R
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STRUCTURE OF THE MECHANOSENSITIVE CHANNEL PIEZO1
Descriptor:Piezo-type mechanosensitive ion channel component 1, unknown fragment
Authors:Guo, Y.R., MacKinnon, R.
Deposit date:2017-09-22
Release date:2017-12-20
Last modified:2018-05-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure-based membrane dome mechanism for Piezo mechanosensitivity.
Elife, 6, 2017
5VMS
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CRYOEM STRUCTURE OF XENOPUS KCNQ1 CHANNEL
Descriptor:Potassium voltage-gated channel subfamily KQT member 1, Calmodulin, CALCIUM ION
Authors:Mackinnon, R., Sun, J.
Deposit date:2017-04-28
Release date:2017-06-07
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
Cell, 169, 2017
5VA1
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CRYO-EM STRUCTURE OF THE HUMAN ETHER-A-GO-GO RELATED K+ CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W., MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA2
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CRYO-EM STRUCTURE OF THE HUMAN ETHER-A-GO-GO RELATED K+ CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W., MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA3
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CRYO-EM STRUCTURE OF THE HUMAN ETHER-A-GO-GO RELATED K+ CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W., MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5U70
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CHICKEN SLO2.2 IN AN OPEN CONFORMATION VITRIFIED IN THE PRESENCE OF 300 MM NACL
Descriptor:Potassium channel subfamily T member 1
Authors:Hite, R.K., MacKinnon, R.
Deposit date:2016-12-09
Release date:2017-02-08
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel.
Cell, 168, 2017
5U76
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CHICKEN SLO2.2 IN A CLOSED CONFORMATION VITRIFIED IN THE PRESENCE OF 300 MM NACL
Descriptor:Potassium channel subfamily T member 1
Authors:Hite, R.K., MacKinnon, R.
Deposit date:2016-12-11
Release date:2017-02-08
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel.
Cell, 168, 2017
5U6O
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STRUCTURE OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Lee, C.-H., MacKinnon, R.
Deposit date:2016-12-08
Release date:2017-01-25
Last modified:2017-09-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5U6P
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STRUCTURE OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL IN COMPLEX WITH CAMP
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Lee, C.-H., MacKinnon, R.
Deposit date:2016-12-08
Release date:2017-01-25
Last modified:2017-09-27
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5TR1
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CRYO-ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC-K CHLORIDE CHANNEL, ALTERNATE (CLASS 2) CONFORMATION
Descriptor:Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E., MacKinnon, R.
Deposit date:2016-10-25
Release date:2017-01-11
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5TQQ
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CRYO-ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC-K CHLORIDE CHANNEL, MAIN (CLASS 1) CONFORMATION
Descriptor:Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E., MacKinnon, R.
Deposit date:2016-10-24
Release date:2017-01-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5TJI
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-04
Release date:2016-12-28
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5TJ6
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, POTASSIUM ION, MAGNESIUM ION, ...
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-03
Release date:2016-12-14
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5K7L
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SINGLE PARTICLE CRYO-EM STRUCTURE OF THE VOLTAGE-GATED K+ CHANNEL EAG1 BOUND TO THE CHANNEL INHIBITOR CALMODULIN
Descriptor:Potassium voltage-gated channel subfamily H member 1, Calmodulin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Whicher, J.R., MacKinnon, R.
Deposit date:2016-05-26
Release date:2016-08-17
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism.
Science, 353, 2016
5A6E
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CRYO-EM STRUCTURE OF THE SLO2.2 NA-ACTIVATED K CHANNEL
Descriptor:S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, ...
Authors:Hite, R.K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., MacKinnon, R.
Deposit date:2015-06-25
Release date:2015-10-14
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
5A6F
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CRYO-EM STRUCTURE OF THE SLO2.2 NA-ACTIVATED K CHANNEL
Descriptor:GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1
Authors:Hite, R.K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., MacKinnon, R.
Deposit date:2015-06-25
Release date:2015-10-14
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
5A6G
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CRYO-EM STRUCTURE OF THE SLO2.2 NA-ACTIVATED K CHANNEL
Descriptor:S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1
Authors:Hite, R.K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., MacKinnon, R.
Deposit date:2015-06-25
Release date:2015-10-14
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
4WFE
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HUMAN TRAAK K+ CHANNEL IN A K+ BOUND CONDUCTIVE CONFORMATION
Descriptor:Potassium channel subfamily K member 4, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ...
Authors:Brohawn, S.G., MacKinnon, R.
Deposit date:2014-09-15
Release date:2014-12-03
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014