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3G4A
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CRYSTAL STRUCTURE OF FLAVINE DEPENDANT THYMIDYLATE SYNTHASE S88A MUTANT FROM THERMOTOGA MARITIMA AT 1.95 ANGSTROM RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Lesley, S.A., Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
3G4C
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FLAVINE DEPENDANT THYMIDYLATE SYNTAHSE S88C MUTANT
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Lesley, S.A., Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
1LM4
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STRUCTURE OF PEPTIDE DEFORMYLASE FROM STAPHYLOCOCCUS AUREUS AT 1.45 A
Descriptor:peptide deformylase PDF1, FE (III) ION, GLYCEROL
Authors:Kreusch, A., Spraggon, G., Lee, C.C., Klock, H., McMullan, D., Ng, K., Shin, T., Vincent, J., Warner, I., Ericson, C., Lesley, S.A.
Deposit date:2002-04-30
Release date:2003-06-24
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LM6
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:peptide deformylase DEFB, FE (III) ION, GLYCEROL
Authors:Kreusch, A., Spraggon, G., Lee, C.C., Klock, H., McMullan, D., Ng, K., Shin, T., Vincent, J., Warner, I., Ericson, C., Lesley, S.A.
Deposit date:2002-04-30
Release date:2003-06-24
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1LME
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM THERMOTOGA MARITIMA
Descriptor:peptide deformylase
Authors:Kreusch, A., Spraggon, G., Lee, C.C., Klock, H., McMullan, D., Ng, K., Shin, T., Vincent, J., Warner, I., Ericson, C., Lesley, S.A., Joint Center for Structural Genomics (JCSG)
Deposit date:2002-05-01
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1N5N
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CRYSTAL STRUCTURE OF PEPTIDE DEFORMYLASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:Peptide deformylase, ZINC ION, GLYCEROL
Authors:Kreusch, A., Spraggon, G., Lee, C.C., Klock, H., McMullan, D., Ng, K., Shin, T., Vincent, J., Warner, I., Ericson, C., Lesley, S.A.
Deposit date:2002-11-06
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase
J.MOL.BIOL., 330, 2003
1O24
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA AT 2.0 A RESOLUTION
Descriptor:Thymidylate synthase thyX
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O25
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH DUMP AT 2.4 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-20
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O26
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND DUMP AT 1.6 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O27
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND BRDUMP AT 2.3 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O28
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FDUMP AT 2.1 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O29
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND FDUMP AT 2.0 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O2A
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AT 1.8 A RESOLUTION
Descriptor:Thymidylate synthase thyX, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O2B
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND PO4 AT 2.45 A RESOLUTION
Descriptor:Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1R73
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SOLUTION STRUCTURE OF TM1492, THE L29 RIBOSOMAL PROTEIN FROM THERMOTOGA MARITIMA
Descriptor:50S ribosomal protein L29
Authors:Peti, W., Etezady-Esfarjani, T., Herrmann, T., Klock, H.E., Lesley, S.A., Wuethrich, K., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-10-17
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR for structural proteomics of Thermotoga maritima: Screening and structure determination
J.STRUCT.FUNCT.GENOM., 5, 2004
1RDU
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NMR STRUCTURE OF A PUTATIVE NIFB PROTEIN FROM THERMOTOGA (TM1290), WHICH BELONGS TO THE DUF35 FAMILY
Descriptor:conserved hypothetical protein
Authors:Etezady-Esfarjani, T., Herrmann, T., Peti, W., Klock, H.E., Lesley, S.A., Wuthrich, K., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-11-06
Release date:2004-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR Structure Determination of the Hypothetical Protein TM1290 from Thermotoga Maritima using Automated NOESY Analysis.
J.Biomol.NMR, 29, 2004
1S96
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THE 2.0 A X-RAY STRUCTURE OF GUANYLATE KINASE FROM E.COLI
Descriptor:Guanylate kinase, PHOSPHATE ION, UNKNOWN ATOM OR ION
Authors:Kreusch, A., Spraggon, G., Klock, H.E., McMullan, D., Vincent, J., Rodrigues, K., Lesley, S.A.
Deposit date:2004-02-03
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of Guanylate Kinase from Escherichia coli at 2.0 A resolution
To be Published
1SJ5
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CRYSTAL STRUCTURE OF A DUF151 FAMILY PROTEIN (TM0160) FROM THERMOTOGA MARITIMA AT 2.8 A RESOLUTION
Descriptor:conserved hypothetical protein TM0160
Authors:Spraggon, G., Panatazatos, D., Klock, H.E., Wilson, I.A., Woods Jr., V.L., Lesley, S.A., Joint Center for Structural Genomics (JCSG)
Deposit date:2004-03-02
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Protein Sci., 13, 2004
1YC1
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CRYSTAL STRUCTURES OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
1YC3
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CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
1YC4
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CRYSTAL STRUCTURE OF HUMAN HSP90ALPHA COMPLEXED WITH DIHYDROXYPHENYLPYRAZOLES
Descriptor:Heat shock protein HSP 90-alpha, 4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE
Authors:Kreusch, A., Han, S., Brinker, A., Zhou, V., Choi, H., He, Y., Lesley, S.A., Caldwell, J., Gu, X.
Deposit date:2004-12-21
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Bioorg.Med.Chem.Lett., 15, 2005
2AQX
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CRYSTAL STRUCTURE OF THE CATALYTIC AND CAM-BINDING DOMAINS OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE B
Descriptor:PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Chamberlain, P.P., Sandberg, M.L., Sauer, K., Cooke, M.P., Lesley, S.A., Spraggon, G.
Deposit date:2005-08-18
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B
Biochemistry, 44, 2005
2IUB
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CRYSTAL STRUCTURE OF A DIVALENT METAL ION TRANSPORTER CORA AT 2.9 A RESOLUTION.
Descriptor:DIVALENT CATION TRANSPORT-RELATED PROTEIN, CHLORIDE ION, MAGNESIUM ION
Authors:Eshaghi, S., Niegowski, D., Kohl, A., Martinez Molina, D., Lesley, S.A., Nordlund, P.
Deposit date:2006-06-01
Release date:2006-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of a Divalent Metal Ion Transporter Cora at 2.9 Angstrom Resolution.
Science, 313, 2006
2OP3
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THE STRUCTURE OF CATHEPSIN S WITH A NOVEL 2-ARYLPHENOXYACETALDEHYDE INHIBITOR DERIVED BY THE SUBSTRATE ACTIVITY SCREENING (SAS) METHOD
Descriptor:Cathepsin S, SULFATE ION, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, ...
Authors:Spraggon, G., Inagaki, H., Tsuruoka, H., Hornsby, M., Lesley, S.A., Ellman, J.A.
Deposit date:2007-01-26
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J.Med.Chem., 50, 2007
2Q7D
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CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+
Descriptor:Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, SULFATE ION, ...
Authors:Chamberlain, P.P., Lesley, S.A., Spraggon, G.
Deposit date:2007-06-06
Release date:2007-07-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007