4J12
| monomeric Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, human Fc fragment | Authors: | Ishino, T, Wang, M, Mosyak, L, Tam, A, Duan, W, Svenson, K, Joyce, A, O'Hara, D, Lin, L, Somers, W, Kriz, R. | Deposit date: | 2013-01-31 | Release date: | 2013-05-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics. J.Biol.Chem., 288, 2013
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3B2Z
| Crystal Structure of ADAMTS4 (apo form) | Descriptor: | ADAMTS-4, CALCIUM ION, ZINC ION | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-19 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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2RJQ
| Crystal structure of ADAMTS5 with inhibitor bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, ADAMTS-5, ... | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-15 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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3FXY
| Acidic Mammalian Chinase, Catalytic Domain | Descriptor: | Acidic mammalian chitinase | Authors: | Olland, A.M. | Deposit date: | 2009-01-21 | Release date: | 2009-03-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Triad of polar residues implicated in pH specificity of acidic mammalian chitinase. Protein Sci., 18, 2009
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3FY1
| The Acidic Mammalian Chitinase catalytic domain in complex with methylallosamidin | Descriptor: | 2-acetamido-2-deoxy-6-O-methyl-alpha-D-allopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-allopyranose, ALLOSAMIZOLINE, Acidic mammalian chitinase | Authors: | Olland, A.M. | Deposit date: | 2009-01-21 | Release date: | 2009-03-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Triad of polar residues implicated in pH specificity of acidic mammalian chitinase. Protein Sci., 18, 2009
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2RJP
| Crystal structure of ADAMTS4 with inhibitor bound | Descriptor: | ADAMTS-4, CALCIUM ION, N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine, ... | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-15 | Release date: | 2007-12-11 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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2ID5
| Crystal Structure of the Lingo-1 Ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine rich repeat neuronal 6A, ... | Authors: | Mosyak, L, Wood, A, Dwyer, B, Johnson, M, Stahl, M.L, Somers, W.S. | Deposit date: | 2006-09-14 | Release date: | 2006-09-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J.Biol.Chem., 281, 2006
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4KIK
| Human IkB kinase beta | Descriptor: | Inhibitor of nuclear factor kappa-B kinase subunit beta, K-252A | Authors: | Liu, S, Mosyak, L. | Deposit date: | 2013-05-02 | Release date: | 2013-06-26 | Last modified: | 2013-08-28 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer. J.Biol.Chem., 288, 2013
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7CNG
| Structure of CDK5R1 bound FEM1B | Descriptor: | Protein fem-1 homolog B,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2020-07-31 | Release date: | 2020-10-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LBG
| Structure of OR51B2 bound FEM1C | Descriptor: | Protein fem-1 homolog C,Peptide from Olfactory receptor 51B2, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-14 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LE6
| Structure of LNLPTQGRAR bound FEM1C | Descriptor: | Protein fem-1 homolog C,10-mer peptide, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-24 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LBF
| Crystal structure of FEM1B | Descriptor: | Protein fem-1 homolog B, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-14 | Release date: | 2020-10-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.252 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LDP
| Structure of CDK5R1-bound FEM1C | Descriptor: | Protein fem-1 homolog C,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-22 | Release date: | 2020-10-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LEN
| Structure of NS11 bound FEM1C | Descriptor: | Protein fem-1 homolog C,NS11 peptide | Authors: | Chen, x, Liao, S, Xu, C. | Deposit date: | 2019-11-25 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.383 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LBN
| Structure of SIL1-bound FEM1C | Descriptor: | Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1 | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-14 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.899 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LEY
| Structure of Sil1G bound FEM1C | Descriptor: | Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1 | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-27 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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6LF0
| Structure of FEM1C | Descriptor: | Protein fem-1 homolog C, SULFATE ION | Authors: | Chen, X, Liao, S, Xu, C. | Deposit date: | 2019-11-27 | Release date: | 2020-10-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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