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3NRX
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BU of 3nrx by Molmil
Insights into anti-parallel microtubule crosslinking by PRC1, a conserved non-motor microtubule binding protein
Descriptor: Protein regulator of cytokinesis 1
Authors:Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A.
Deposit date:2010-06-30
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
3NRY
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BU of 3nry by Molmil
Insights into anti-parallel microtubule crosslinking by PRC1, a conserved microtubule binding protein
Descriptor: Protein regulator of cytokinesis 1
Authors:Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A.
Deposit date:2010-07-01
Release date:2010-08-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
8VLS
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BU of 8vls by Molmil
Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-12
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
8VOV
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BU of 8vov by Molmil
Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-16
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
8VKU
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BU of 8vku by Molmil
Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form)
Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase
Authors:Jones, N.H, Urnivicius, L, Kapoor, T.M.
Deposit date:2024-01-09
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc.Natl.Acad.Sci.USA, 121, 2024
5KMG
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BU of 5kmg by Molmil
Near-atomic cryo-EM structure of PRC1 bound to the microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kellogg, E.H, Howes, S, Ti, S.-C, Ramirez-Aportela, E, Kapoor, T.M, Chacon, P, Nogales, E.
Deposit date:2016-06-27
Release date:2016-08-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Near-atomic cryo-EM structure of PRC1 bound to the microtubule.
Proc.Natl.Acad.Sci.USA, 113, 2016
8VRJ
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BU of 8vrj by Molmil
Rigid body fitted model for gamma tubulin ring complex capped microtubule
Descriptor: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ...
Authors:Aher, A, Urnavicius, L, Kapoor, T.M.
Deposit date:2024-01-22
Release date:2024-03-27
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structure of the gamma-tubulin ring complex-capped microtubule.
Nat.Struct.Mol.Biol., 31, 2024
8VRK
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BU of 8vrk by Molmil
Rigid body fitted model for refined density map of gamma tubulin ring complex capped microtubule
Descriptor: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ...
Authors:Aher, A, Urnavicius, L, Kapoor, T.M.
Deposit date:2024-01-22
Release date:2024-03-27
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Structure of the gamma-tubulin ring complex-capped microtubule.
Nat.Struct.Mol.Biol., 31, 2024
8VA2
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BU of 8va2 by Molmil
Symmetry expanded map of 2 gamma-tubulins bound to 2 alpha tubulins in gamma tubulin ring complex capped microtubule end.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Aher, A, Urnavicius, L, Kapoor, T.M.
Deposit date:2023-12-10
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Symmetry expanded map of 2 gamma-tubulins bound to 2 alpha tubulins.
To Be Published
6P11
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BU of 6p11 by Molmil
Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Drosophila melanogaster Spastin AAA domain, ...
Authors:Pisa, R, Cupido, T, Kapoor, T.M.
Deposit date:2019-05-17
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6P10
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BU of 6p10 by Molmil
Structure of spastin AAA domain (N527C mutant) in complex with JNJ-7706621 inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Drosophila melanogaster Spastin AAA domain, ...
Authors:Pisa, R, Cupido, T, Kapoor, T.M.
Deposit date:2019-05-17
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6P12
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BU of 6p12 by Molmil
Structure of spastin AAA domain (wild-type) in complex with diaminotriazole-based inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, Drosophila melanogaster Spastin AAA domain, ...
Authors:Pisa, R, Cupido, T, Kapoor, T.M.
Deposit date:2019-05-17
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94131851 Å)
Cite:Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6P14
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BU of 6p14 by Molmil
Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form B)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, ACETATE ION, ...
Authors:Pisa, R, Cupido, T, Kapoor, T.M.
Deposit date:2019-05-17
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93001127 Å)
Cite:Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
6P13
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BU of 6p13 by Molmil
Structure of spastin AAA domain (T692A mutant) in complex with a diaminotriazole-based inhibitor (crystal form A)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, SULFATE ION, ...
Authors:Pisa, R, Cupido, T, Kapoor, T.M.
Deposit date:2019-05-17
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26, 2019
5IJ9
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BU of 5ij9 by Molmil
Cryo EM density of microtubule assembled from human TUBB3-D417H mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ti, S.C, Pamula, M.C, Howes, S.C, Duellberg, C, Cade, N.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M.
Deposit date:2016-03-01
Release date:2016-04-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
Dev.Cell, 37, 2016
5IJ0
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BU of 5ij0 by Molmil
Cryo EM density of microtubule assembled from human TUBB3
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ti, S.-C, Pamula, M.C, Howes, S.C, Duellberg, C, Nicholas, C.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M.
Deposit date:2016-03-01
Release date:2016-04-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
Dev.Cell, 37, 2016
4L6Y
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BU of 4l6y by Molmil
Structure of the microtubule associated protein PRC1 (Protein Regulator of Cytokinesis 1)
Descriptor: Protein regulator of cytokinesis 1
Authors:Subramanian, R, Ti, S, Tan, L, Darst, S.A, Kapoor, T.M.
Deposit date:2013-06-13
Release date:2013-07-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.3015 Å)
Cite:Marking and Measuring Single Microtubules by PRC1 and Kinesin-4.
Cell(Cambridge,Mass.), 154, 2013
4L3I
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BU of 4l3i by Molmil
Structure of the microtubule associated protein PRC1 (Protein Regulator of Cytokinesis 1)
Descriptor: Protein regulator of cytokinesis 1
Authors:Subramanian, R, Ti, S, Tan, L, Darst, S.A, Kapoor, T.M.
Deposit date:2013-06-06
Release date:2013-07-17
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3.6005 Å)
Cite:Marking and Measuring Single Microtubules by PRC1 and Kinesin-4.
Cell(Cambridge,Mass.), 154, 2013
8VT7
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BU of 8vt7 by Molmil
Structure of the gamma tubulin ring complex nucleated microtubule protofilament.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Aher, A, Urnavicius, L, Kapoor, T.M.
Deposit date:2024-01-25
Release date:2024-03-27
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structure of the gamma-tubulin ring complex-capped microtubule.
Nat.Struct.Mol.Biol., 31, 2024
8VRD
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BU of 8vrd by Molmil
Rigid body fitted model for free recombinant gamma tubulin ring complex.
Descriptor: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ...
Authors:Aher, A, Urnavicius, L, Kapoor, T.M.
Deposit date:2024-01-21
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Rigid body fitted model for free recombinant gamma tubulin ring complex.
To be published
6E7B
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BU of 6e7b by Molmil
13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Ti, S.C, Alushin, G.M, Kapoor, T.M.
Deposit date:2018-07-25
Release date:2018-10-10
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.
Dev. Cell, 47, 2018
6E7C
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BU of 6e7c by Molmil
14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Ti, S.C, Alushin, G.M, Kapoor, T.M.
Deposit date:2018-07-25
Release date:2018-10-10
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.
Dev. Cell, 47, 2018
6V69
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BU of 6v69 by Molmil
Structures of GCP4 and GCP5 in the native human gamma-tubulin ring complex
Descriptor: Gamma-tubulin complex component 4, Gamma-tubulin complex component 5
Authors:Wieczorek, M, Urnavicius, L, Ti, S, Molloy, K.R, Chait, B.T, Kapoor, T.M.
Deposit date:2019-12-04
Release date:2020-01-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex.
Cell, 180, 2020
6V6S
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BU of 6v6s by Molmil
Structure of the native human gamma-tubulin ring complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Gamma-tubulin complex component 2, ...
Authors:Wieczorek, M, Urnavicius, L, Ti, S, Molloy, K.R, Chait, B.T, Kapoor, T.M.
Deposit date:2019-12-05
Release date:2020-01-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex.
Cell, 180, 2020
6V6C
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BU of 6v6c by Molmil
Structure of GCP6 in the native human gamma-tubulin ring complex
Descriptor: Gamma-tubulin complex component 6
Authors:Wieczorek, M, Urnavicius, L, Ti, S, Molloy, K.R, Chait, B.T, Kapoor, T.M.
Deposit date:2019-12-04
Release date:2020-01-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex.
Cell, 180, 2020

 

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