Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor

Summary for 6P11

DescriptorDrosophila melanogaster Spastin AAA domain, SULFATE ION, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (5 entities in total)
Functional Keywordsinhibitor, complex, aaa protein, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological sourceDrosophila melanogaster (Fruit fly)
Total number of polymer chains1
Total molecular weight34899.6
Pisa, R.,Cupido, T.,Kapoor, T.M. (deposition date: 2019-05-17, release date: 2019-07-24, Last modification date: 2020-01-01)
Primary citation
Pisa, R.,Cupido, T.,Steinman, J.B.,Jones, N.H.,Kapoor, T.M.
Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
Cell Chem Biol, 26:1263-, 2019
PubMed: 31257183 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2019.06.001
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24140 1.5% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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