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5H2X
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BU of 5h2x by Molmil
Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172)
Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1
Authors:Hirano, H, Matsuura, Y.
Deposit date:2016-10-18
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p
J. Mol. Biol., 429, 2017
5H2W
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BU of 5h2w by Molmil
Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)
Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1
Authors:Hirano, H, Matsuura, Y.
Deposit date:2016-10-18
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p
J. Mol. Biol., 429, 2017
5B2O
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BU of 5b2o by Molmil
Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGG PAM)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O.
Deposit date:2016-02-01
Release date:2016-03-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Engineering of Francisella novicida Cas9
Cell, 164, 2016
5B2Q
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BU of 5b2q by Molmil
Crystal structure of Francisella novicida Cas9 RHA in complex with sgRNA and target DNA (TGG PAM)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O.
Deposit date:2016-02-01
Release date:2016-03-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Engineering of Francisella novicida Cas9
Cell, 164, 2016
5B2P
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BU of 5b2p by Molmil
Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGA PAM)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O.
Deposit date:2016-02-01
Release date:2016-03-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Engineering of Francisella novicida Cas9
Cell, 164, 2016
3TPM
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BU of 3tpm by Molmil
Crystal structure of MAL RPEL domain in complex with importin-alpha
Descriptor: Importin subunit alpha-2, MAL
Authors:Hirano, H, Matsuura, Y.
Deposit date:2011-09-08
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL
Biochem.Biophys.Res.Commun., 414, 2011
3TPO
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BU of 3tpo by Molmil
Crystal structure of D192A/E396A mutant of mouse importin alpha2
Descriptor: Importin subunit alpha-2
Authors:Hirano, H, Matsuura, Y.
Deposit date:2011-09-08
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL
Biochem.Biophys.Res.Commun., 414, 2011
3TPQ
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BU of 3tpq by Molmil
Crystal structure of wild-type MAL RPEL domain in complex with five G-actins
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Hirano, H, Matsuura, Y.
Deposit date:2011-09-08
Release date:2011-10-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL
Biochem.Biophys.Res.Commun., 414, 2011
6AEL
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BU of 6ael by Molmil
Crystal structure of ENPP1 in complex with 3'3'-cGAMP
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ...
Authors:Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O.
Deposit date:2018-08-05
Release date:2019-03-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nat Commun, 9, 2018
6AEK
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BU of 6aek by Molmil
Crystal structure of ENPP1 in complex with pApG
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ...
Authors:Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O.
Deposit date:2018-08-05
Release date:2019-03-06
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nat Commun, 9, 2018
5X2G
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BU of 5x2g by Molmil
Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACC PAM)
Descriptor: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ...
Authors:Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O.
Deposit date:2017-01-31
Release date:2017-03-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
Mol. Cell, 65, 2017
5X2H
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BU of 5x2h by Molmil
Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACA PAM)
Descriptor: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ...
Authors:Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O.
Deposit date:2017-01-31
Release date:2017-03-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
Mol. Cell, 65, 2017
7C7L
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BU of 7c7l by Molmil
Cryo-EM structure of the Cas12f1-sgRNA-target DNA complex
Descriptor: CRISPR-associated protein Cas14a.1, DNA (40-mer), ZINC ION, ...
Authors:Takeda, N.S, Nakagawa, R, Okazaki, S, Hirano, H, Kobayashi, K, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O.
Deposit date:2020-05-26
Release date:2020-12-23
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the miniature type V-F CRISPR-Cas effector enzyme.
Mol.Cell, 81, 2021
5WUN
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BU of 5wun by Molmil
Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1
Descriptor: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
Authors:Nakada, R, Hirano, H, Matsuura, Y.
Deposit date:2016-12-19
Release date:2017-01-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
5WUM
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BU of 5wum by Molmil
Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1
Descriptor: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1
Authors:Nakada, R, Hirano, H, Matsuura, Y.
Deposit date:2016-12-19
Release date:2017-01-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Biochem. Biophys. Res. Commun., 484, 2017
8J12
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BU of 8j12 by Molmil
Cryo-EM structure of the AsCas12f-sgRNA-target DNA ternary complex
Descriptor: DNA (38-MER), MAGNESIUM ION, RNA (247-MER), ...
Authors:Hino, T, Omura, N.S, Nakagawa, R, Togashi, T, Takeda, N.S, Hiramoto, T, Tasaka, S, Hirano, H, Tokuyama, T, Uosaki, H, Ishiguro, H, Yamano, H, Ozaki, Y, Motooka, D, Mori, H, Kirita, Y, Kise, Y, Itoh, Y, Matoba, S, Aburatani, H, Yachie, N, Siksnys, V, Ohmori, T, Hoshino, A, Nureki, O.
Deposit date:2023-04-12
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Minimal and most efficient genome editing Cas enzyme
To Be Published
8J1J
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BU of 8j1j by Molmil
Cryo-EM structure of the AsCas12f-YHAM-sgRNAS3-5v7-target DNA
Descriptor: DNA (38-MER), MAGNESIUM ION, RNA (118-MER), ...
Authors:Hino, T, Omura, N.S, Nakagawa, R, Togashi, T, Takeda, N.S, Hiramoto, T, Tasaka, S, Hirano, H, Tokuyama, T, Uosaki, H, Ishiguro, H, Yamano, H, Ozaki, Y, Motooka, D, Mori, H, Kirita, Y, Kise, Y, Itoh, Y, Matoba, S, Aburatani, H, Yachie, N, Siksnys, V, Ohmori, T, Hoshino, A, Nureki, O.
Deposit date:2023-04-13
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Minimal and most efficient genome editing Cas enzyme
To Be Published
8J3R
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BU of 8j3r by Molmil
Cryo-EM structure of the AsCas12f-HKRA-sgRNAS3-5v7-target DNA
Descriptor: DNA (37-MER), DNA (38-MER), MAGNESIUM ION, ...
Authors:Hino, T, Omura, N.S, Nakagawa, R, Togashi, T, Takeda, N.S, Hiramoto, T, Tasaka, S, Hirano, H, Tokuyama, T, Uosaki, H, Ishiguro, H, Yamano, H, Ozaki, Y, Motooka, D, Mori, H, Kirita, Y, Kise, Y, Itoh, Y, Matoba, S, Aburatani, H, Yachie, N, Siksnys, V, Ohmori, T, Hoshino, A, Nureki, O.
Deposit date:2023-04-18
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Minimal and most efficient genome editing Cas enzyme
To Be Published
7VTI
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BU of 7vti by Molmil
Crystal structure of the Cas13bt3-crRNA binary complex
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ...
Authors:Nakagawa, R, Takeda, N.S, Tomita, A, Hirano, H, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O.
Deposit date:2021-10-29
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure and engineering of the minimal type VI CRISPR-Cas13bt3.
Mol.Cell, 82, 2022
7VTN
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BU of 7vtn by Molmil
Cryo-EM structure of the Cas13bt3-crRNA-target RNA ternary complex
Descriptor: Cas13bt3, crRNA, target RNA
Authors:Nakagawa, R, Soumya, K, Han, A, Takeda, N.S, Tomita, A, Hirano, H, Kusakizako, T, Tomohiro, N, Yamashita, K, Feng, Z, Nishimasu, H, Nureki, O.
Deposit date:2021-10-30
Release date:2022-09-07
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structure and engineering of the minimal type VI CRISPR-Cas13bt3.
Mol.Cell, 82, 2022
1JU8
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BU of 1ju8 by Molmil
Solution structure of Leginsulin, a plant hormon
Descriptor: Leginsulin
Authors:Yamazaki, T, Takaoka, M, Katoh, E, Hanada, K, Sakita, M, Sakata, K, Nishiuchi, Y, Hirano, H.
Deposit date:2001-08-23
Release date:2003-06-17
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes
EUR.J.BIOCHEM., 270, 2003
8WUT
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BU of 8wut by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (initiation)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8WUS
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BU of 8wus by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (termination)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8WUU
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BU of 8wuu by Molmil
SpCas9-pegRNA-target DNA complex (pre-initiation)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (34-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8WUV
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BU of 8wuv by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 16-nt)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (50-MER), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024

 

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