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3BQI
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BU of 3bqi by Molmil
Structure of a chondroitin sulphate binding DBL3X from a var2csa encoded PfEMP1 protein
Descriptor: Erythrocyte membrane protein 1, GLYCEROL
Authors:Higgins, M.K.
Deposit date:2007-12-20
Release date:2008-06-24
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
3BQL
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BU of 3bql by Molmil
Structure of a chondroitin sulphate binding DBL3X domain from a var2csa encoded PfEMP1 protein
Descriptor: Erythrocyte membrane protein 1, GLYCEROL, SULFATE ION
Authors:Higgins, M.K.
Deposit date:2007-12-20
Release date:2008-06-24
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
4E40
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BU of 4e40 by Molmil
The haptoglobin-hemoglobin receptor of Trypanosoma congolense
Descriptor: Putative uncharacterized protein
Authors:Higgins, M.K, Tkachenko, O, Brown, A, Reed, J, Carrington, M.
Deposit date:2012-03-11
Release date:2013-01-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Proc.Natl.Acad.Sci.USA, 110, 2013
3BQK
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BU of 3bqk by Molmil
Structure of a chondroitin sulphate binding DBL3X from a var2csa encoded PfEMP1 protein in complex with sulphate
Descriptor: Erythrocyte membrane protein 1, GLYCEROL, SULFATE ION
Authors:Higgins, M.K.
Deposit date:2007-12-20
Release date:2008-06-24
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
1T5E
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BU of 1t5e by Molmil
The structure of MexA
Descriptor: D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA
Authors:Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V.
Deposit date:2004-05-04
Release date:2004-05-18
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the periplasmic component of a bacterial drug efflux pump
Proc.Natl.Acad.Sci.USA, 101, 2004
1TQQ
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BU of 1tqq by Molmil
Structure of TolC in complex with hexamminecobalt
Descriptor: COBALT HEXAMMINE(III), Outer membrane protein tolC
Authors:Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V.
Deposit date:2004-06-18
Release date:2004-07-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
4V3D
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BU of 4v3d by Molmil
The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ...
Authors:Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
5MI0
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BU of 5mi0 by Molmil
A thermally stabilised version of Plasmodium falciparum RH5
Descriptor: MONOCLONAL ANTIBODY 9AD4, Reticulocyte binding-like protein 5,Reticulocyte binding protein 5
Authors:Campeotto, I, Goldenzweig, A, Davey, J, Barfod, L, Marshall, J.M, Silk, S.E, Wright, K.E, Draper, S.J, Higgins, M.K, Fleishman, S.J.
Deposit date:2016-11-27
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6H5N
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BU of 6h5n by Molmil
Plasmodium falciparum Pfs48/45 C-terminal domain bound to monoclonal antibody 85RF45.1
Descriptor: Antibody 85RF45.1 heavy chain, Antibody 85RF45.1 light chain, Gametocyte surface protein P45/48
Authors:Lennartz, F, Higgins, M.K.
Deposit date:2018-07-25
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody.
Nat Commun, 9, 2018
6XZ6
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BU of 6xz6 by Molmil
Structure of the trypanosome brucei factor H receptor bound to domain D5 of bovine factor H
Descriptor: Complement factor H, GARP domain-containing protein
Authors:Macleod, O.J.S, Carrington, M, Higgins, M.K.
Deposit date:2020-02-02
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Nat Commun, 11, 2020
8RZ2
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BU of 8rz2 by Molmil
PfRH5 bound to monoclonal antibody R5.034
Descriptor: R5.034 heavy chain, R5.034 light chain, Reticulocyte binding protein 5
Authors:Farrell, B, Higgins, M.K.
Deposit date:2024-02-11
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:PfRH5 bound to monoclonal antibody R5.034
To Be Published
8RZ0
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BU of 8rz0 by Molmil
Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016
Descriptor: GLYCEROL, R5.016 scFv, RH5-34EM
Authors:Farrell, B, Harrison, T, Higgins, M.K.
Deposit date:2024-02-11
Release date:2024-07-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016
To Be Published
8RZ1
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BU of 8rz1 by Molmil
Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.034
Descriptor: R5.034 scFv, RH5-34EM
Authors:Farrell, B, Higgins, M.K.
Deposit date:2024-02-11
Release date:2024-07-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.034
To Be Published
8CDE
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BU of 8cde by Molmil
PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
Descriptor: Cy.003, Cy.003 light chain, Cysteine-rich protective antigen, ...
Authors:Farrell, B, Higgins, M.K.
Deposit date:2023-01-30
Release date:2023-10-25
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The PfRCR complex bridges malaria parasite and erythrocyte during invasion.
Nature, 625, 2024
8CDD
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BU of 8cdd by Molmil
PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
Descriptor: Cy.003 heavy chain, Cy.003 light chain, Cysteine-rich protective antigen, ...
Authors:Farrell, B, Higgins, M.K.
Deposit date:2023-01-30
Release date:2023-10-25
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The PfRCR complex bridges malaria parasite and erythrocyte during invasion.
Nature, 625, 2024
5HU6
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BU of 5hu6 by Molmil
Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Haptoglobin, Haptoglobin-hemoglobin receptor, ...
Authors:Lane-Serff, H, Higgins, M.K.
Deposit date:2016-01-27
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
5NST
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BU of 5nst by Molmil
Human monoclonal antibody with a LAIR1 insertion
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy Chain of antibody MGD21, ...
Authors:Hsieh, F.-L, Higgins, M.K.
Deposit date:2017-04-26
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Elife, 6, 2017
5MZA
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BU of 5mza by Molmil
The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Erythrocyte membrane protein 1 (PfEMP1), ...
Authors:Lennartz, F, Higgins, M.K.
Deposit date:2017-01-31
Release date:2017-03-22
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.
Cell Host Microbe, 21, 2017
4V3E
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BU of 4v3e by Molmil
The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ...
Authors:Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
4X0J
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BU of 4x0j by Molmil
Trypanosoma brucei haptoglobin-haemoglobin receptor
Descriptor: Haptoglobin-hemoglobin receptor
Authors:Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K.
Deposit date:2014-11-21
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
4X0L
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BU of 4x0l by Molmil
Human haptoglobin-haemoglobin complex
Descriptor: CACODYLATE ION, GLYCEROL, Haptoglobin, ...
Authors:Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K.
Deposit date:2014-11-21
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
6Z3T
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BU of 6z3t by Molmil
Structure of canine Sec61 inhibited by mycolactone
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
Authors:Gerard, S.F, Higgins, M.K.
Deposit date:2020-05-21
Release date:2020-07-22
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structure of the Inhibited State of the Sec Translocon.
Mol.Cell, 79, 2020
6ZYV
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BU of 6zyv by Molmil
Structure of a Plasmodium PIR protein ectodomain
Descriptor: CIR protein
Authors:Harrison, T.E, Higgins, M.K.
Deposit date:2020-08-03
Release date:2020-11-25
Last modified:2021-01-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the Plasmodium -interspersed repeat proteins of the malaria parasite.
Proc.Natl.Acad.Sci.USA, 117, 2020
6ZDX
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BU of 6zdx by Molmil
RIFIN variable region bound to LILRB1 ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leukocyte immunoglobulin-like receptor subfamily B member 1, ...
Authors:Harrison, T.E, Higgins, M.K.
Deposit date:2020-06-15
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
Nature, 587, 2020
7ZXF
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BU of 7zxf by Molmil
Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1
Descriptor: 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ...
Authors:Ko, K.T, Lennartz, F.L, Higgins, M.K.
Deposit date:2022-05-20
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.72 Å)
Cite:Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022

 

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