1PR9
| Human L-Xylulose Reductase Holoenzyme | Descriptor: | DIHYDROGENPHOSPHATE ION, L-XYLULOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | El-Kabbani, O, Ishikura, S, Darmanin, C, Carbone, V, Chung, R.P.-T, Usami, N, Hara, A. | Deposit date: | 2003-06-20 | Release date: | 2004-02-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis Proteins, 55, 2004
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3ADO
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1WNT
| Structure of the tetrameric form of Human L-Xylulose Reductase | Descriptor: | L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | El-Kabbani, O, Carbone, V, Darmanin, C, Ishikura, S, Hara, A. | Deposit date: | 2004-08-09 | Release date: | 2005-07-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis Proteins, 60, 2005
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3ADP
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4D9S
| Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8) | Descriptor: | UVB-resistance protein UVR8 | Authors: | Arvai, A.S, Christie, J.M, Pratt, A.J, Hitomi, K, Getzoff, E.D. | Deposit date: | 2012-01-11 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges. Science, 335, 2012
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1CYD
| CARBONYL REDUCTASE COMPLEXED WITH NADPH AND 2-PROPANOL | Descriptor: | CARBONYL REDUCTASE, ISOPROPYL ALCOHOL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Tanaka, N, Nonaka, T, Mitsui, Y. | Deposit date: | 1995-09-01 | Release date: | 1996-10-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure, 4, 1996
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3FX4
| Porcine aldehyde reductase in ternary complex with inhibitor | Descriptor: | Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | Authors: | Carbone, V, El-Kabbani, O. | Deposit date: | 2009-01-20 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor. Eur.J.Med.Chem., 45, 2010
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3GUG
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6KX8
| Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX7
| Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6KX5
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6KX4
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6KX6
| Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound | Descriptor: | Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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2ZAT
| Crystal structure of a mammalian reductase | Descriptor: | Dehydrogenase/reductase SDR family member 4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Tanaka, N, Aoki, K, Nakamura, K.T. | Deposit date: | 2007-10-10 | Release date: | 2008-04-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular basis for peroxisomal localization of tetrameric carbonyl reductase. Structure, 16, 2008
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2P5N
| Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Aldo-keto reductase family 1, member C21, ... | Authors: | El-Kabbani, O, Dhagat, U. | Deposit date: | 2007-03-15 | Release date: | 2007-10-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme. Acta Crystallogr.,Sect.F, 63, 2007
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6LUE
| Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 | Descriptor: | 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 | Authors: | Miller, S, Aikawa, Y, Hirota, T. | Deposit date: | 2020-01-27 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
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3C3U
| Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid | Descriptor: | 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Dhagat, U, El-Kabbani, O. | Deposit date: | 2008-01-28 | Release date: | 2008-08-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid J.Med.Chem., 51, 2008
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3O3R
| Crystal Structure of AKR1B14 in complex with NADP | Descriptor: | Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Sundaram, K, Dhagat, U, El-Kabbani, O. | Deposit date: | 2010-07-26 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis Bioorg.Med.Chem.Lett., 21, 2011
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3NTY
| Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid | Descriptor: | 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Dhagat, U, El-Kabbani, O. | Deposit date: | 2010-07-06 | Release date: | 2011-04-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis Bioorg.Med.Chem.Lett., 21, 2011
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3OHS
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3QKZ
| Crystal structure of mutant His269Arg AKR1B14 | Descriptor: | Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Sundaram, K, El-Kabbani, O. | Deposit date: | 2011-02-02 | Release date: | 2012-02-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH. Acta Crystallogr.,Sect.F, 68, 2012
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2O4U
| Crystal structure of Mammalian Dimeric Dihydrodiol Dehydrogenase | Descriptor: | BETA-MERCAPTOETHANOL, Dimeric dihydrodiol dehydrogenase, GLYCEROL, ... | Authors: | Carbone, V, El-Kabbani, O. | Deposit date: | 2006-12-04 | Release date: | 2007-07-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis. Proteins, 70, 2008
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2O48
| Crystal structure of Mammalian Dimeric Dihydrodiol Dehydrogenase | Descriptor: | BETA-MERCAPTOETHANOL, Dimeric dihydrodiol dehydrogenase, P-HYDROXYACETOPHENONE, ... | Authors: | Carbone, V, El-Kabbani, O. | Deposit date: | 2006-12-04 | Release date: | 2007-07-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis. Proteins, 70, 2008
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2POQ
| Dimeric Dihydrodiol Dehydrogenase complexed with inhibitor, Isoascorbic acid | Descriptor: | BETA-MERCAPTOETHANOL, Dimeric dihydrodiol dehydrogenase, ISOASCORBIC ACID, ... | Authors: | Carbone, V, El-Kabbani, O. | Deposit date: | 2007-04-27 | Release date: | 2007-07-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid. Acta Crystallogr.,Sect.D, 64, 2008
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2D1Y
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