2P5N

Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH

Summary for 2P5N

DescriptorAldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywordsaldo-keto reductase, hydroxysteroid dehydrogenase, binary complex, tim barrel, oxidoreductase
Biological sourceMus musculus (house mouse)
Total number of polymer chains2
Total molecular weight75576.35
Authors
El-Kabbani, O.,Dhagat, U. (deposition date: 2007-03-15, release date: 2007-10-09, Last modification date: 2013-11-20)
Primary citation
Dhagat, U.,Carbone, V.,Chung, R.P.,Schulze-Briese, C.,Endo, S.,Hara, A.,El-Kabbani, O.
Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63:825-830, 2007
PubMed: 17909281 (PDB entries with the same primary citation)
DOI: 10.1107/S1744309107040985
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267704.9%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2p5n
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Molmil generated image of 2p5n
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Molmil generated image of 2p5n
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More Biological unit images

Molmil generated image of 2p5n
no rotation
Molmil generated image of 2p5n
rotated about x axis by 90°
Molmil generated image of 2p5n
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2p5n.pdb1.gz [60.36 KB])
Coordinate files for Biological unit (2p5n.pdb2.gz [61.55 KB])