Author results

1PR9
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HUMAN L-XYLULOSE REDUCTASE HOLOENZYME
Descriptor:L-XYLULOSE REDUCTASE, POTASSIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P.-T., Usami, N., Hara, A.
Deposit date:2003-06-20
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis
Proteins, 55, 2004
1WNT
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STRUCUTRE OF THE TETRAMERIC FORM OF HUMAN L-XYLULOSE REDUCTASE
Descriptor:L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Carbone, V., Darmanin, C., Ishikura, S., Hara, A.
Deposit date:2004-08-09
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
Proteins, 60, 2005
3ADO
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CRYSTAL STRUCTURE OF THE RABBIT L-GULONATE 3-DEHYDROGENASE
Descriptor:Lambda-crystallin
Authors:Asada, Y., Hara, A., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-01-26
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the Rabbit L-Gulonate 3-Dehydrogenase
To be Published
3ADP
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CRYSTAL STRUCTURE OF THE RABBIT L-GULONATE 3-DEHYDROGENASE (NADH FORM)
Descriptor:Lambda-crystallin, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
Authors:Asada, Y., Hara, A., Kunishima, N., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-01-26
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Rabbit L-Gulonate 3-Dehydrogenase
To be Published
1CYD
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CARBONYL REDUCTASE COMPLEXED WITH NADPH AND 2-PROPANOL
Descriptor:CARBONYL REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOPROPYL ALCOHOL
Authors:Tanaka, N., Nonaka, T., Mitsui, Y.
Deposit date:1995-09-01
Release date:1996-10-14
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
Structure, 4, 1996
2O48
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, P-HYDROXYACETOPHENONE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2O4U
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, PHOSPHATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2P5N
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CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH COENZYME NADPH
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Dhagat, U.
Deposit date:2007-03-15
Release date:2007-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63, 2007
2POQ
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DIMERIC DIHYDRODIOL DEHYDROGENASE COMPLEXED WITH INHIBITOR, ISOASCORBIC ACID
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2007-04-27
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
Acta Crystallogr.,Sect.D, 64, 2008
2ZAT
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CRYSTAL STRUCTURE OF A MAMMALIAN REDUCTASE
Descriptor:Dehydrogenase/reductase SDR family member 4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Tanaka, N., Aoki, K., Nakamura, K.T.
Deposit date:2007-10-10
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis for peroxisomal localization of tetrameric carbonyl reductase.
Structure, 16, 2008
3C3U
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CRYSTAL STRUCTURE OF AKR1C1 IN COMPLEX WITH NADP AND 3,5-DICHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-01-28
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem., 51, 2008
3CV6
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THE CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE GG225.226PP MUTANT IN COMPLEX WITH INHIBITOR AND COFACTOR NADP+.
Descriptor:Aldo-keto reductase family 1 member C21, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-04-17
Release date:2009-03-03
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.
Acta Crystallogr.,Sect.D, 65, 2009
3CV7
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CRYSTAL STRUCTURE OF PORCINE ALDEHYDE REDUCTASE TERNARY COMPLEX
Descriptor:Alcohol dehydrogenase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2008-04-18
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.412 Å)
Cite:Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Arch.Biochem.Biophys., 479, 2008
3D3W
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STRUCTURE OF L-XYLULOSE REDUCTASE WITH BOUND COENZYME, PHOSPHATE AND HYDROXIDE.
Descriptor:L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION
Authors:Zhao, H.-T., El-Kabbani, O.
Deposit date:2008-05-12
Release date:2009-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
Cell.Mol.Life Sci., 66, 2009
3FJN
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THE CRYSTAL STRUCTURE OF 17-ALPHA HYDROXYSTEROID DEHYDROGENASE Y224D MUTANT.
Descriptor:Aldo-keto reductase family 1 member C21, ACETATE ION
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2008-12-14
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
Acta Crystallogr.,Sect.D, 66, 2010
3GUG
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CRYSTAL STRUCTURE OF AKR1C1 L308V MUTANT IN COMPLEX WITH NADP AND 3,5-DICHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5-dichloro-2-hydroxybenzoic acid, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2009-03-30
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
To be Published
3NTY
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CRYSTAL STRUCTURE OF AKR1C1 IN COMPLEX WITH NADP AND 5-PHENYL,3-CHLOROSALICYLIC ACID
Descriptor:Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-4-hydroxybiphenyl-3-carboxylic acid, ...
Authors:Dhagat, U., El-Kabbani, O.
Deposit date:2010-07-06
Release date:2011-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
3O3R
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CRYSTAL STRUCTURE OF AKR1B14 IN COMPLEX WITH NADP
Descriptor:Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sundaram, K., Dhagat, U., El-Kabbani, O.
Deposit date:2010-07-26
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Bioorg.Med.Chem.Lett., 21, 2011
3OHS
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE IN COMPLEX WITH DIHYDROXYACETONE
Descriptor:Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Zhao, H.-T., El-Kabbani, O.
Deposit date:2010-08-18
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of MDD in complex with Dihydroxyacetone
To be Published
3QKZ
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CRYSTAL STRUCTURE OF MUTANT HIS269ARG AKR1B14
Descriptor:Aldo-keto reductase family 1, member B7, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sundaram, K., El-Kabbani, O.
Deposit date:2011-02-02
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH.
Acta Crystallogr.,Sect.F, 68, 2012
4D9S
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA UVR8 (UV RESISTANCE LOCUS 8)
Descriptor:UVB-resistance protein UVR8
Authors:Arvai, A.S., Christie, J.M., Pratt, A.J., Hitomi, K., Getzoff, E.D.
Deposit date:2012-01-11
Release date:2012-04-04
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges.
Science, 335, 2012